Deep Learning-Based Early-Stage IR-Drop Estimation via CNN Surrogate Modeling

IR-drop is a critical power integrity challenge in modern VLSI designs that can cause timing degradation, reliability issues, and functional failures if not detected early in the design flow. Conventional IR-drop analysis relies on physics-based signoff tools, which provide high accuracy but incur significant computational cost and require near-final layout information, making them unsuitable for rapid early-stage design exploration. In this work, we propose a deep learning-based surrogate modeling approach for early-stage IR-drop estimation using a CNN. The task is formulated as a dense pixel-wise regression problem, where spatial physical layout features are mapped directly to IR-drop heatmaps. A U-Net-based encoder-decoder architecture with skip connections is employed to effectively capture both local and global spatial dependencies within the layout. The model is trained on a physics-inspired synthetic dataset generated by us, which incorporates key physical factors including power grid structure, cell density distribution, and switching activity. Model performance is evaluated using standard regression metrics such as Mean Squared Error (MSE) and Peak Signal-to-Noise Ratio (PSNR). Experimental results demonstrate that the proposed approach can accurately predict IR-drop distributions with millisecond-level inference time, enabling fast pre-signoff screening and iterative design optimization. The proposed framework is intended as a complementary early-stage analysis tool, providing designers with rapid IR-drop insight prior to expensive signoff analysis. The implementation, dataset generation scripts, and the interactive inference application are publicly available at: https://github.com/riteshbhadana/IR-Drop-Predictor. The live application can be accessed at: https://ir-drop-predictor.streamlit.app/.

Analyzing Images of Blood Cells with Quantum Machine Learning Methods: Equilibrium Propagation and Variational Quantum Circuits to Detect Acute Myeloid Leukemia

This paper presents a feasibility study demonstrating that quantum machine learning (QML) algorithms achieve competitive performance on real-world medical imaging despite operating under severe constraints. We evaluate Equilibrium Propagation (EP), an energy-based learning method that does not use backpropagation (incompatible with quantum systems due to state-collapsing measurements) and Variational Quantum Circuits (VQCs) for automated detection of Acute Myeloid Leukemia (AML) from blood cell microscopy images using binary classification (2 classes: AML vs. Healthy). Key Result: Using limited subsets (50-250 samples per class) of the AML-Cytomorphology dataset (18,365 expert-annotated images), quantum methods achieve performance only 12-15% below classical CNNs despite reduced image resolution (64x64 pixels), engineered features (20D), and classical simulation via Qiskit. EP reaches 86.4% accuracy (only 12% below CNN) without backpropagation, while the 4-qubit VQC attains 83.0% accuracy with consistent data efficiency: VQC maintains stable 83% performance with only 50 samples per class, whereas CNN requires 250 samples (5x more data) to reach 98%. These results establish reproducible baselines for QML in healthcare, validating NISQ-era feasibility.

A Machine Vision Approach to Preliminary Skin Lesion Assessments

Early detection of malignant skin lesions is critical for improving patient outcomes in aggressive, metastatic skin cancers. This study evaluates a comprehensive system for preliminary skin lesion assessment that combines the clinically established ABCD rule of dermoscopy (analyzing Asymmetry, Borders, Color, and Dermoscopic Structures) with machine learning classification. Using a 1,000-image subset of the HAM10000 dataset, the system implements an automated, rule-based pipeline to compute a Total Dermoscopy Score (TDS) for each lesion. This handcrafted approach is compared against various machine learning solutions, including traditional classifiers (Logistic Regression, Random Forest, and SVM) and deep learning models. While the rule-based system provides high clinical interpretability, results indicate a performance bottleneck when reducing complex morphology to five numerical features. Experimental findings show that transfer learning with EfficientNet-B0 failed significantly due to domain shift between natural and medical images. In contrast, a custom three-layer Convolutional Neural Network (CNN) trained from scratch achieved 78.5% accuracy and 86.5% recall on median-filtered images, representing a 19-point accuracy improvement over traditional methods. The results demonstrate that direct pixel-level learning captures diagnostic patterns beyond handcrafted features and that purpose-built lightweight architectures can outperform large pretrained models for small, domain-specific medical datasets.

KAGE-Bench: Fast Known-Axis Visual Generalization Evaluation for Reinforcement Learning

Pixel-based reinforcement learning agents often fail under purely visual distribution shift even when latent dynamics and rewards are unchanged, but existing benchmarks entangle multiple sources of shift and hinder systematic analysis. We introduce KAGE-Env, a JAX-native 2D platformer that factorizes the observation process into independently controllable visual axes while keeping the underlying control problem fixed. By construction, varying a visual axis affects performance only through the induced state-conditional action distribution of a pixel policy, providing a clean abstraction for visual generalization. Building on this environment, we define KAGE-Bench, a benchmark of six known-axis suites comprising 34 train-evaluation configuration pairs that isolate individual visual shifts. Using a standard PPO-CNN baseline, we observe strong axis-dependent failures, with background and photometric shifts often collapsing success, while agent-appearance shifts are comparatively benign. Several shifts preserve forward motion while breaking task completion, showing that return alone can obscure generalization failures. Finally, the fully vectorized JAX implementation enables up to 33M environment steps per second on a single GPU, enabling fast and reproducible sweeps over visual factors. Code: https://avanturist322.github.io/KAGEBench/.

An Innovative Framework for Breast Cancer Detection Using Pyramid Adaptive Atrous Convolution, Transformer Integration, and Multi-Scale Feature Fusion

Breast cancer is one of the most common cancers among women worldwide, and its accurate and timely diagnosis plays a critical role in improving treatment outcomes. This thesis presents an innovative framework for detecting malignant masses in mammographic images by integrating the Pyramid Adaptive Atrous Convolution (PAAC) and Transformer architectures. The proposed approach utilizes Multi-Scale Feature Fusion to enhance the extraction of features from benign and malignant tissues and combines Dice Loss and Focal Loss functions to improve the model's learning process, effectively reducing errors in binary breast cancer classification and achieving high accuracy and efficiency. In this study, a comprehensive dataset of breast cancer images from INbreast, MIAS, and DDSM was preprocessed through data augmentation and contrast enhancement and resized to 227x227 pixels for model training. Leveraging the Transformer's ability to manage long-range dependencies with Self-Attention mechanisms, the proposed model achieved high accuracy in detecting cancerous masses, outperforming foundational models such as BreastNet, DeepMammo, Multi-Scale CNN, Swin-Unet, and SegFormer. The final evaluation results for the proposed model include an accuracy of 98.5\%, sensitivity of 97.8\%, specificity of 96.3\%, F1-score of 98.2\%, and overall precision of 97.9\%. These metrics demonstrate a significant improvement over traditional methods and confirm the model's effectiveness in identifying cancerous masses in complex scenarios and large datasets. This model shows potential as a reliable and efficient tool for breast cancer diagnosis and can be effectively integrated into medical diagnostic systems.

Accurate Simulation Pipeline for Passive Single-Photon Imaging

Single-Photon Avalanche Diodes (SPADs) are new and promising imaging sensors. These sensors are sensitive enough to detect individual photons hitting each pixel, with extreme temporal resolution and without readout noise. Thus, SPADs stand out as an optimal choice for low-light imaging. Due to the high price and limited availability of SPAD sensors, the demand for an accurate data simulation pipeline is substantial. Indeed, the scarcity of SPAD datasets hinders the development of SPAD-specific processing algorithms and impedes the training of learning-based solutions. In this paper, we present a comprehensive SPAD simulation pipeline and validate it with multiple experiments using two recent commercial SPAD sensors. Our simulator is used to generate the SPAD-MNIST, a single-photon version of the seminal MNIST dataset, to investigate the effectiveness of convolutional neural network (CNN) classifiers on reconstructed fluxes, even at extremely low light conditions, e.g., 5 mlux. We also assess the performance of classifiers exclusively trained on simulated data on real images acquired from SPAD sensors at different light conditions. The synthetic dataset encompasses different SPAD imaging modalities and is made available for download. Project page: https://boracchi.faculty.polimi.it/Projects/SPAD-MNIST.html.

Pigment Network Detection and Classification in Dermoscopic Images Using Directional Imaging Algorithms and Convolutional Neural Networks

Early diagnosis of melanoma, which can save thousands of lives, relies heavily on the analysis of dermoscopic images. One crucial diagnostic criterion is the identification of unusual pigment network (PN). However, distinguishing between regular (typical) and irregular (atypical) PN is challenging. This study aims to automate the PN detection process using a directional imaging algorithm and classify PN types using machine learning classifiers. The directional imaging algorithm incorporates Principal Component Analysis (PCA), contrast enhancement, filtering, and noise reduction. Applied to the PH2 dataset, this algorithm achieved a 96% success rate, which increased to 100% after pixel intensity adjustments. We created a new dataset containing only PN images from these results. We then employed two classifiers, Convolutional Neural Network (CNN) and Bag of Features (BoF), to categorize PN into atypical and typical classes. Given the limited dataset of 200 images, a simple and effective CNN was designed, featuring two convolutional layers and two batch normalization layers. The proposed CNN achieved 90% accuracy, 90% sensitivity, and 89% specificity. When compared to state-of-the-art methods, our CNN demonstrated superior performance. Our study highlights the potential of the proposed CNN model for effective PN classification, suggesting future research should focus on expanding datasets and incorporating additional dermatological features to further enhance melanoma diagnosis.

Integrating Color Histogram Analysis and Convolutional Neural Network for Skin Lesion Classification

The color of skin lesions is an important diagnostic feature for identifying malignant melanoma and other skin diseases. Typical colors associated with melanocytic lesions include tan, brown, black, red, white, and blue gray. This study introduces a novel feature: the number of colors present in a lesion, which can indicate the severity of disease and help distinguish melanomas from benign lesions. We propose a color histogram analysis method to examine lesion pixel values from three publicly available datasets: PH2, ISIC2016, and Med Node. The PH2 dataset contains ground truth annotations of lesion colors, while ISIC2016 and Med Node do not; our algorithm estimates the ground truth using color histogram analysis based on PH2. We then design and train a 19 layer Convolutional Neural Network (CNN) with residual skip connections to classify lesions into three categories based on the number of colors present. DeepDream visualization is used to interpret features learned by the network, and multiple CNN configurations are tested. The best model achieves a weighted F1 score of 75 percent. LIME is applied to identify important regions influencing model decisions. The results show that the number of colors in a lesion is a significant feature for describing skin conditions, and the proposed CNN with three skip connections demonstrates strong potential for clinical diagnostic support.

Detail Loss in Super-Resolution Models Based on the Laplacian Pyramid and Repeated Upscaling and Downscaling Process

With advances in artificial intelligence, image processing has gained significant interest. Image super-resolution is a vital technology closely related to real-world applications, as it enhances the quality of existing images. Since enhancing fine details is crucial for the super-resolution task, pixels that contribute to high-frequency information should be emphasized. This paper proposes two methods to enhance high-frequency details in super-resolution images: a Laplacian pyramid-based detail loss and a repeated upscaling and downscaling process. Total loss with our detail loss guides a model by separately generating and controlling super-resolution and detail images. This approach allows the model to focus more effectively on high-frequency components, resulting in improved super-resolution images. Additionally, repeated upscaling and downscaling amplify the effectiveness of the detail loss by extracting diverse information from multiple low-resolution features. We conduct two types of experiments. First, we design a CNN-based model incorporating our methods. This model achieves state-of-the-art results, surpassing all currently available CNN-based and even some attention-based models. Second, we apply our methods to existing attention-based models on a small scale. In all our experiments, attention-based models adding our detail loss show improvements compared to the originals. These results demonstrate our approaches effectively enhance super-resolution images across different model structures.

A Comparative Study of Custom CNNs, Pre-trained Models, and Transfer Learning Across Multiple Visual Datasets

Convolutional Neural Networks (CNNs) are a standard approach for visual recognition due to their capacity to learn hierarchical representations from raw pixels. In practice, practitioners often choose among (i) training a compact custom CNN from scratch, (ii) using a large pre-trained CNN as a fixed feature extractor, and (iii) performing transfer learning via partial or full fine-tuning of a pre-trained backbone. This report presents a controlled comparison of these three paradigms across five real-world image classification datasets spanning road-surface defect recognition, agricultural variety identification, fruit/leaf disease recognition, pedestrian walkway encroachment recognition, and unauthorized vehicle recognition. Models are evaluated using accuracy and macro F1-score, complemented by efficiency metrics including training time per epoch and parameter counts. The results show that transfer learning consistently yields the strongest predictive performance, while the custom CNN provides an attractive efficiency--accuracy trade-off, especially when compute and memory budgets are constrained.