Evaluating the Usefulness of Non-Diagnostic Speech Data for Developing Parkinson's Disease Classifiers

Speech-based Parkinson's disease (PD) detection has gained attention for its automated, cost-effective, and non-intrusive nature. As research studies usually rely on data from diagnostic-oriented speech tasks, this work explores the feasibility of diagnosing PD on the basis of speech data not originally intended for diagnostic purposes, using the Turn-Taking (TT) dataset. Our findings indicate that TT can be as useful as diagnostic-oriented PD datasets like PC-GITA. We also investigate which specific dataset characteristics impact PD classification performance. The results show that concatenating audio recordings and balancing participants' gender and status distributions can be beneficial. Cross-dataset evaluation reveals that models trained on PC-GITA generalize poorly to TT, whereas models trained on TT perform better on PC-GITA. Furthermore, we provide insights into the high variability across folds, which is mainly due to large differences in individual speaker performance.

BenSParX: A Robust Explainable Machine Learning Framework for Parkinson's Disease Detection from Bengali Conversational Speech

Parkinson's disease (PD) poses a growing global health challenge, with Bangladesh experiencing a notable rise in PD-related mortality. Early detection of PD remains particularly challenging in resource-constrained settings, where voice-based analysis has emerged as a promising non-invasive and cost-effective alternative. However, existing studies predominantly focus on English or other major languages; notably, no voice dataset for PD exists for Bengali - posing a significant barrier to culturally inclusive and accessible healthcare solutions. Moreover, most prior studies employed only a narrow set of acoustic features, with limited or no hyperparameter tuning and feature selection strategies, and little attention to model explainability. This restricts the development of a robust and generalizable machine learning model. To address this gap, we present BenSparX, the first Bengali conversational speech dataset for PD detection, along with a robust and explainable machine learning framework tailored for early diagnosis. The proposed framework incorporates diverse acoustic feature categories, systematic feature selection methods, and state-of-the-art machine learning algorithms with extensive hyperparameter optimization. Furthermore, to enhance interpretability and trust in model predictions, the framework incorporates SHAP (SHapley Additive exPlanations) analysis to quantify the contribution of individual acoustic features toward PD detection. Our framework achieves state-of-the-art performance, yielding an accuracy of 95.77%, F1 score of 95.57%, and AUC-ROC of 0.982. We further externally validated our approach by applying the framework to existing PD datasets in other languages, where it consistently outperforms state-of-the-art approaches. To facilitate further research and reproducibility, the dataset has been made publicly available at https://github.com/Riad071/BenSParX.

Variational Autoencoder for Personalized Pathological Speech Enhancement

The generalizability of speech enhancement (SE) models across speaker conditions remains largely unexplored, despite its critical importance for broader applicability. This paper investigates the performance of the hybrid variational autoencoder (VAE)-non-negative matrix factorization (NMF) model for SE, focusing primarily on its generalizability to pathological speakers with Parkinson's disease. We show that VAE models trained on large neurotypical datasets perform poorly on pathological speech. While fine-tuning these pre-trained models with pathological speech improves performance, a performance gap remains between neurotypical and pathological speakers. To address this gap, we propose using personalized SE models derived from fine-tuning pre-trained models with only a few seconds of clean data from each speaker. Our results demonstrate that personalized models considerably enhance performance for all speakers, achieving comparable results for both neurotypical and pathological speakers.

Bilingual Dual-Head Deep Model for Parkinson's Disease Detection from Speech

This work aims to tackle the Parkinson's disease (PD) detection problem from the speech signal in a bilingual setting by proposing an ad-hoc dual-head deep neural architecture for type-based binary classification. One head is specialized for diadochokinetic patterns. The other head looks for natural speech patterns present in continuous spoken utterances. Only one of the two heads is operative accordingly to the nature of the input. Speech representations are extracted from self-supervised learning (SSL) models and wavelet transforms. Adaptive layers, convolutional bottlenecks, and contrastive learning are exploited to reduce variations across languages. Our solution is assessed against two distinct datasets, EWA-DB, and PC-GITA, which cover Slovak and Spanish languages, respectively. Results indicate that conventional models trained on a single language dataset struggle with cross-linguistic generalization, and naive combinations of datasets are suboptimal. In contrast, our model improves generalization on both languages, simultaneously.

Robust Cross-Etiology and Speaker-Independent Dysarthric Speech Recognition

In this paper, we present a speaker-independent dysarthric speech recognition system, with a focus on evaluating the recently released Speech Accessibility Project (SAP-1005) dataset, which includes speech data from individuals with Parkinson's disease (PD). Despite the growing body of research in dysarthric speech recognition, many existing systems are speaker-dependent and adaptive, limiting their generalizability across different speakers and etiologies. Our primary objective is to develop a robust speaker-independent model capable of accurately recognizing dysarthric speech, irrespective of the speaker. Additionally, as a secondary objective, we aim to test the cross-etiology performance of our model by evaluating it on the TORGO dataset, which contains speech samples from individuals with cerebral palsy (CP) and amyotrophic lateral sclerosis (ALS). By leveraging the Whisper model, our speaker-independent system achieved a CER of 6.99% and a WER of 10.71% on the SAP-1005 dataset. Further, in cross-etiology settings, we achieved a CER of 25.08% and a WER of 39.56% on the TORGO dataset. These results highlight the potential of our approach to generalize across unseen speakers and different etiologies of dysarthria.

Distinguishing Parkinson's Patients Using Voice-Based Feature Extraction and Classification

Parkinson's disease (PD) is a progressive neurodegenerative disorder that impacts motor functions and speech characteristics This study focuses on differentiating individuals with Parkinson's disease from healthy controls through the extraction and classification of speech features. Patients were further divided into 2 groups. Med On represents the patient with medication, while Med Off represents the patient without medication. The dataset consisted of patients and healthy individuals who read a predefined text using the H1N Zoom microphone in a suitable recording environment at F{\i}rat University Neurology Department. Speech recordings from PD patients and healthy controls were analyzed, and 19 key features were extracted, including jitter, luminance, zero-crossing rate (ZCR), root mean square (RMS) energy, entropy, skewness, and kurtosis.These features were visualized in graphs and statistically evaluated to identify distinctive patterns in PD patients. Using MATLAB's Classification Learner toolbox, several machine learning classification algorithm models were applied to classify groups and significant accuracy rates were achieved. The accuracy of our 3-layer artificial neural network architecture was also compared with classical machine learning algorithms. This study highlights the potential of noninvasive voice analysis combined with machine learning for early detection and monitoring of PD patients. Future research can improve diagnostic accuracy by optimizing feature selection and exploring advanced classification techniques.

Towards a Generalizable Speech Marker for Parkinson's Disease Diagnosis

Parkinson's Disease (PD) is a neurodegenerative disorder characterized by motor symptoms, including altered voice production in the early stages. Early diagnosis is crucial not only to improve PD patients' quality of life but also to enhance the efficacy of potential disease-modifying therapies during early neurodegeneration, a window often missed by current diagnostic tools. In this paper, we propose a more generalizable approach to PD recognition through domain adaptation and self-supervised learning. We demonstrate the generalization capabilities of the proposed approach across diverse datasets in different languages. Our approach leverages HuBERT, a large deep neural network originally trained for speech recognition and further trains it on unlabeled speech data from a population that is similar to the target group, i.e., the elderly, in a self-supervised manner. The model is then fine-tuned and adapted for use across different datasets in multiple languages, including English, Italian, and Spanish. Evaluations on four publicly available PD datasets demonstrate the model's efficacy, achieving an average specificity of 92.1% and an average sensitivity of 91.2%. This method offers objective and consistent evaluations across large populations, addressing the variability inherent in human assessments and providing a non-invasive, cost-effective and accessible diagnostic option.

A quantum inspired predictor of Parkinsons disease built on a diverse, multimodal dataset

Parkinsons disease, the fastest growing neurodegenerative disorder globally, has seen a 50 percent increase in cases within just two years. As speech, memory, and motor symptoms worsen over time, early diagnosis is crucial for preserving patients quality of life. While machine-learning-based detection has shown promise, relying on a single feature for classification can be error-prone due to the variability of symptoms between patients. To address this limitation we utilized the mPower database, which includes 150,000 samples across four key biomarkers: voice, gait, tapping, and demographic data. From these measurements, we extracted 64 features and trained a baseline Random Forest model to select the features above the 80th percentile. For classification, we designed a simulatable quantum support vector machine (qSVM) that detects high-dimensional patterns, leveraging recent advancements in quantum machine learning. With a novel, simulatable architecture that can be run on standard hardware rather than resource-intensive quantum computers, our model achieves an accuracy of 90 percent and an AUC of 0.98, surpassing benchmark models. By utilizing an innovative classification framework built on a diverse set of features, our model offers a pathway for accessible global Parkinsons screening.

Empowering Dysarthric Speech: Leveraging Advanced LLMs for Accurate Speech Correction and Multimodal Emotion Analysis

Dysarthria is a motor speech disorder caused by neurological damage that affects the muscles used for speech production, leading to slurred, slow, or difficult-to-understand speech. It affects millions of individuals worldwide, including those with conditions such as stroke, traumatic brain injury, cerebral palsy, Parkinsons disease, and multiple sclerosis. Dysarthria presents a major communication barrier, impacting quality of life and social interaction. This paper introduces a novel approach to recognizing and translating dysarthric speech, empowering individuals with this condition to communicate more effectively. We leverage advanced large language models for accurate speech correction and multimodal emotion analysis. Dysarthric speech is first converted to text using OpenAI Whisper model, followed by sentence prediction using fine-tuned open-source models and benchmark models like GPT-4.o, LLaMA 3.1 70B and Mistral 8x7B on Groq AI accelerators. The dataset used combines the TORGO dataset with Google speech data, manually labeled for emotional context. Our framework identifies emotions such as happiness, sadness, neutrality, surprise, anger, and fear, while reconstructing intended sentences from distorted speech with high accuracy. This approach demonstrates significant advancements in the recognition and interpretation of dysarthric speech.

Differential privacy for protecting patient data in speech disorder detection using deep learning

Speech pathology has impacts on communication abilities and quality of life. While deep learning-based models have shown potential in diagnosing these disorders, the use of sensitive data raises critical privacy concerns. Although differential privacy (DP) has been explored in the medical imaging domain, its application in pathological speech analysis remains largely unexplored despite the equally critical privacy concerns. This study is the first to investigate DP's impact on pathological speech data, focusing on the trade-offs between privacy, diagnostic accuracy, and fairness. Using a large, real-world dataset of 200 hours of recordings from 2,839 German-speaking participants, we observed a maximum accuracy reduction of 3.85% when training with DP with a privacy budget, denoted by {\epsilon}, of 7.51. To generalize our findings, we validated our approach on a smaller dataset of Spanish-speaking Parkinson's disease patients, demonstrating that careful pretraining on large-scale task-specific datasets can maintain or even improve model accuracy under DP constraints. We also conducted a comprehensive fairness analysis, revealing that reasonable privacy levels (2<{\epsilon}<10) do not introduce significant gender bias, though age-related disparities may require further attention. Our results suggest that DP can effectively balance privacy and utility in speech disorder detection, but also highlight the unique challenges in the speech domain, particularly regarding the privacy-fairness trade-off. This provides a foundation for future work to refine DP methodologies and address fairness across diverse patient groups in real-world deployments.