EthosGPT: Mapping Human Value Diversity to Advance Sustainable Development Goals (SDGs)

Large language models (LLMs) are transforming global decision-making and societal systems by processing diverse data at unprecedented scales. However, their potential to homogenize human values poses critical risks, similar to biodiversity loss undermining ecological resilience. Rooted in the ancient Greek concept of ethos, meaning both individual character and the shared moral fabric of communities, EthosGPT draws on a tradition that spans from Aristotle's virtue ethics to Adam Smith's moral sentiments as the ethical foundation of economic cooperation. These traditions underscore the vital role of value diversity in fostering social trust, institutional legitimacy, and long-term prosperity. EthosGPT addresses the challenge of value homogenization by introducing an open-source framework for mapping and evaluating LLMs within a global scale of human values. Using international survey data on cultural indices, prompt-based assessments, and comparative statistical analyses, EthosGPT reveals both the adaptability and biases of LLMs across regions and cultures. It offers actionable insights for developing inclusive LLMs, such as diversifying training data and preserving endangered cultural heritage to ensure representation in AI systems. These contributions align with the United Nations Sustainable Development Goals (SDGs), especially SDG 10 (Reduced Inequalities), SDG 11.4 (Cultural Heritage Preservation), and SDG 16 (Peace, Justice and Strong Institutions). Through interdisciplinary collaboration, EthosGPT promotes AI systems that are both technically robust and ethically inclusive, advancing value plurality as a cornerstone for sustainable and equitable futures.

Linguistic Comparison of AI- and Human-Written Responses to Online Mental Health Queries

The ubiquity and widespread use of digital and online technologies have transformed mental health support, with online mental health communities (OMHCs) providing safe spaces for peer support. More recently, generative AI and large language models (LLMs) have introduced new possibilities for scalable, around-the-clock mental health assistance that could potentially augment and supplement the capabilities of OMHCs. Although genAI shows promise in delivering immediate and personalized responses, their effectiveness in replicating the nuanced, experience-based support of human peers remains an open question. In this study, we harnessed 24,114 posts and 138,758 online community (OC) responses from 55 OMHCs on Reddit. We prompted several state-of-the-art LLMs (GPT-4-Turbo, Llama-3, and Mistral-7B) with these posts, and compared their (AI) responses to human-written (OC) responses based on a variety of linguistic measures across psycholinguistics and lexico-semantics. Our findings revealed that AI responses are more verbose, readable, and analytically structured, but lack linguistic diversity and personal narratives inherent in human-human interactions. Through a qualitative examination, we found validation as well as complementary insights into the nature of AI responses, such as its neutrality of stance and the absence of seeking back-and-forth clarifications. We discuss the ethical and practical implications of integrating generative AI into OMHCs, advocating for frameworks that balance AI's scalability and timeliness with the irreplaceable authenticity, social interactiveness, and expertise of human connections that form the ethos of online support communities.

GAAPO: Genetic Algorithmic Applied to Prompt Optimization

Large Language Models (LLMs) have demonstrated remarkable capabilities across various tasks, with their performance heavily dependent on the quality of input prompts \cite{schulhoff2025promptsurvey} \cite{sahoo2025promptengineering}. While prompt engineering has proven effective, it typically relies on manual adjustments, making it time-consuming and potentially suboptimal. This paper introduces GAAPO (Genetic Algorithm Applied to Prompt Optimization), a novel hybrid optimization framework that leverages genetic algorithm \cite{dejong1988gen} principles to evolve prompts through successive generations. Unlike traditional genetic approaches that rely solely on mutation and crossover operations, GAAPO integrates multiple specialized prompt generation strategies within its evolutionary framework. Through extensive experimentation on diverse datasets including ETHOS, MMLU-Pro, and GPQA, our analysis reveals several important point for the future development of automatic prompt optimization methods: importance of the tradeoff between the population size and the number of generations, effect of selection methods on stability results, capacity of different LLMs and especially reasoning models to be able to automatically generate prompts from similar queries... Furthermore, we provide insights into the relative effectiveness of different prompt generation strategies and their evolution across optimization phases. These findings contribute to both the theoretical understanding of prompt optimization and practical applications in improving LLM performance.

Foundation Model of Electronic Medical Records for Adaptive Risk Estimation

We developed the Enhanced Transformer for Health Outcome Simulation (ETHOS), an AI model that tokenizes patient health timelines (PHTs) from EHRs. ETHOS predicts future PHTs using transformer-based architectures. The Adaptive Risk Estimation System (ARES) employs ETHOS to compute dynamic and personalized risk probabilities for clinician-defined critical events. ARES incorporates a personalized explainability module that identifies key clinical factors influencing risk estimates for individual patients. ARES was evaluated on the MIMIC-IV v2.2 dataset in emergency department (ED) settings, benchmarking its performance against traditional early warning systems and machine learning models. We processed 299,721 unique patients from MIMIC-IV into 285,622 PHTs, with 60% including hospital admissions. The dataset contained over 357 million tokens. ETHOS outperformed benchmark models in predicting hospital admissions, ICU admissions, and prolonged hospital stays, achieving superior AUC scores. ETHOS-based risk estimates demonstrated robustness across demographic subgroups with strong model reliability, confirmed via calibration curves. The personalized explainability module provides insights into patient-specific factors contributing to risk. ARES, powered by ETHOS, advances predictive healthcare AI by providing dynamic, real-time, and personalized risk estimation with patient-specific explainability to enhance clinician trust. Its adaptability and superior accuracy position it as a transformative tool for clinical decision-making, potentially improving patient outcomes and resource allocation in emergency and inpatient settings. We release the full code at github.com/ipolharvard/ethos-ares to facilitate future research.

Harnessing the Potential of Large Language Models in Modern Marketing Management: Applications, Future Directions, and Strategic Recommendations

Large Language Models (LLMs) have revolutionized the process of customer engagement, campaign optimization, and content generation, in marketing management. In this paper, we explore the transformative potential of LLMs along with the current applications, future directions, and strategic recommendations for marketers. In particular, we focus on LLMs major business drivers such as personalization, real-time-interactive customer insights, and content automation, and how they enable customers and business outcomes. For instance, the ethical aspects of AI with respect to data privacy, transparency, and mitigation of bias are also covered, with the goal of promoting responsible use of the technology through best practices and the use of new technologies businesses can tap into the LLM potential, which help growth and stay one step ahead in the turmoil of digital marketing. This article is designed to give marketers the necessary guidance by using best industry practices to integrate these powerful LLMs into their marketing strategy and innovation without compromising on the ethos of their brand.

On the ETHOS of AI Agents: An Ethical Technology and Holistic Oversight System

In a world increasingly defined by machine intelligence, the future depends on how we govern the development and integration of AI into society. Recent initiatives, such as the EU AI Act, EDPB opinion, U.S. Bipartisan House Task Force and NIST AI Risk Management Report, highlight the urgent need for robust governance frameworks to address the challenges posed by advancing AI technologies. However, existing frameworks fail to adequately address the rise of AI agents or the ongoing debate between centralized and decentralized governance models. To bridge these gaps, we propose the Ethical Technology and Holistic Oversight System framework, which leverages Web3 technologies, including blockchain, smart contracts, decentralized autonomous organizations, and soulbound tokens, to establish a decentralized global registry for AI agents. ETHOS incorporates the concept of AI specific legal entities, enabling these systems to assume limited liability and ensuring accountability through mechanisms like insurance and compliance monitoring. Additionally, the framework emphasizes the need for a collaborative, participatory approach to AI governance, engaging diverse stakeholders through public education, transparency, and international coordination. ETHOS balances innovation with ethical accountability, providing a forward looking strategy for the responsible integration of AI agents into society. Finally, this exploration reflects the emergence of a new interdisciplinary field we define as Systems Thinking at the Intersection of AI, Web3, and Society.

The ethical landscape of robot-assisted surgery. A systematic review

Background: Robot-assisted surgery has been widely adopted in recent years. However, compared to other health technologies operating in close proximity to patients in a vulnerable state, ethical issues of robot-assisted surgery have received less attention. Against the background of increasing automation that are expected to raise new ethical issues, this systematic review aims to map the state of the ethical debate in this field. Methods: A protocol was registered in the international prospective register of systematic reviews (PROSPERO CRD42023397951). Medline via PubMed, EMBASE, CINHAL, Philosophers' Index, IEEE Xplorer, Web of Science (Core Collection), Scopus and Google Scholar were searched in January 2023. Screening, extraction, and analysis were conducted independently by two authors. A qualitative narrative synthesis was performed. Results: Out of 1,723 records, 66 records were included in the final dataset. Seven major strands of the ethical debate emerged during analysis. These include questions of harms and benefits, responsibility and control, professional-patient relationship, ethical issues in surgical training and learning, justice, translational questions, and economic considerations. Discussion: The identified themes testify to a broad range of different and differing ethical issues requiring careful deliberation and integration into the surgical ethos. Looking forward, we argue that a different perspective in addressing robotic surgical devices might be helpful to consider upcoming challenges of automation.

Zero Shot Health Trajectory Prediction Using Transformer

Integrating modern machine learning and clinical decision-making has great promise for mitigating healthcare's increasing cost and complexity. We introduce the Enhanced Transformer for Health Outcome Simulation (ETHOS), a novel application of the transformer deep-learning architecture for analyzing high-dimensional, heterogeneous, and episodic health data. ETHOS is trained using Patient Health Timelines (PHTs)-detailed, tokenized records of health events-to predict future health trajectories, leveraging a zero-shot learning approach. ETHOS represents a significant advancement in foundation model development for healthcare analytics, eliminating the need for labeled data and model fine-tuning. Its ability to simulate various treatment pathways and consider patient-specific factors positions ETHOS as a tool for care optimization and addressing biases in healthcare delivery. Future developments will expand ETHOS' capabilities to incorporate a wider range of data types and data sources. Our work demonstrates a pathway toward accelerated AI development and deployment in healthcare.

Research on Tibetan Tourism Viewpoints information generation system based on LLM

Tibet, ensconced within China's territorial expanse, is distinguished by its labyrinthine and heterogeneous topography, a testament to its profound historical heritage, and the cradle of a unique religious ethos. The very essence of these attributes, however, has impeded the advancement of Tibet's tourism service infrastructure, rendering existing smart tourism services inadequate for the region's visitors. This study delves into the ramifications of informational disparities at tourist sites on Tibetan tourism and addresses the challenge of establishing the Large Language Model (LLM) evaluation criteria. It introduces an innovative approach, the DualGen Bridge AI system, employing supervised fine-tuning techniques to bolster model functionality and enhance optimization processes. Furthermore, it pioneers a multi-structured generative results assessment framework. Empirical validation confirms the efficacy of this framework. The study also explores the application of the supervised fine-tuning method within the proprietary DualGen Bridge AI, aimed at refining the generation of tourist site information. The study's findings offer valuable insights for optimizing system performance and provide support and inspiration for the application of LLM technology in Tibet's tourism services and beyond, potentially revolutionizing the smart tourism industry with advanced, tailored information generation capabilities.

Investigating Annotator Bias in Large Language Models for Hate Speech Detection

Data annotation, the practice of assigning descriptive labels to raw data, is pivotal in optimizing the performance of machine learning models. However, it is a resource-intensive process susceptible to biases introduced by annotators. The emergence of sophisticated Large Language Models (LLMs), like ChatGPT presents a unique opportunity to modernize and streamline this complex procedure. While existing research extensively evaluates the efficacy of LLMs, as annotators, this paper delves into the biases present in LLMs, specifically GPT 3.5 and GPT 4o when annotating hate speech data. Our research contributes to understanding biases in four key categories: gender, race, religion, and disability. Specifically targeting highly vulnerable groups within these categories, we analyze annotator biases. Furthermore, we conduct a comprehensive examination of potential factors contributing to these biases by scrutinizing the annotated data. We introduce our custom hate speech detection dataset, HateSpeechCorpus, to conduct this research. Additionally, we perform the same experiments on the ETHOS (Mollas et al., 2022) dataset also for comparative analysis. This paper serves as a crucial resource, guiding researchers and practitioners in harnessing the potential of LLMs for dataannotation, thereby fostering advancements in this critical field. The HateSpeechCorpus dataset is available here: https://github.com/AmitDasRup123/HateSpeechCorpus