Versatile Cardiovascular Signal Generation with a Unified Diffusion Transformer

Cardiovascular signals such as photoplethysmography (PPG), electrocardiography (ECG), and blood pressure (BP) are inherently correlated and complementary, together reflecting the health of cardiovascular system. However, their joint utilization in real-time monitoring is severely limited by diverse acquisition challenges from noisy wearable recordings to burdened invasive procedures. Here we propose UniCardio, a multi-modal diffusion transformer that reconstructs low-quality signals and synthesizes unrecorded signals in a unified generative framework. Its key innovations include a specialized model architecture to manage the signal modalities involved in generation tasks and a continual learning paradigm to incorporate varying modality combinations. By exploiting the complementary nature of cardiovascular signals, UniCardio clearly outperforms recent task-specific baselines in signal denoising, imputation, and translation. The generated signals match the performance of ground-truth signals in detecting abnormal health conditions and estimating vital signs, even in unseen domains, while ensuring interpretability for human experts. These advantages position UniCardio as a promising avenue for advancing AI-assisted healthcare.

Wavelet Integrated Convolutional Neural Network for ECG Signal Denoising

Wearable electrocardiogram (ECG) measurement using dry electrodes has a problem with high-intensity noise distortion. Hence, a robust noise reduction method is required. However, overlapping frequency bands of ECG and noise make noise reduction difficult. Hence, it is necessary to provide a mechanism that changes the characteristics of the noise based on its intensity and type. This study proposes a convolutional neural network (CNN) model with an additional wavelet transform layer that extracts the specific frequency features in a clean ECG. Testing confirms that the proposed method effectively predicts accurate ECG behavior with reduced noise by accounting for all frequency domains. In an experiment, noisy signals in the signal-to-noise ratio (SNR) range of -10-10 are evaluated, demonstrating that the efficiency of the proposed method is higher when the SNR is small.

MSEMG: Surface Electromyography Denoising with a Mamba-based Efficient Network

Surface electromyography (sEMG) recordings can be contaminated by electrocardiogram (ECG) signals when the monitored muscle is closed to the heart. Traditional signal-processing-based approaches, such as high-pass filtering and template subtraction, have been used to remove ECG interference but are often limited in their effectiveness. Recently, neural-network-based methods have shown greater promise for sEMG denoising, but they still struggle to balance both efficiency and effectiveness. In this study, we introduce MSEMG, a novel system that integrates the Mamba State Space Model with a convolutional neural network to serve as a lightweight sEMG denoising model. We evaluated MSEMG using sEMG data from the Non-Invasive Adaptive Prosthetics database and ECG signals from the MIT-BIH Normal Sinus Rhythm Database. The results show that MSEMG outperforms existing methods, generating higher-quality sEMG signals with fewer parameters. The source code for MSEMG is available at https://github.com/tonyliu0910/MSEMG.

MECG-E: Mamba-based ECG Enhancer for Baseline Wander Removal

Electrocardiogram (ECG) is an important non-invasive method for diagnosing cardiovascular disease. However, ECG signals are susceptible to noise contamination, such as electrical interference or signal wandering, which reduces diagnostic accuracy. Various ECG denoising methods have been proposed, but most existing methods yield suboptimal performance under very noisy conditions or require several steps during inference, leading to latency during online processing. In this paper, we propose a novel ECG denoising model, namely Mamba-based ECG Enhancer (MECG-E), which leverages the Mamba architecture known for its fast inference and outstanding nonlinear mapping capabilities. Experimental results indicate that MECG-E surpasses several well-known existing models across multiple metrics under different noise conditions. Additionally, MECG-E requires less inference time than state-of-the-art diffusion-based ECG denoisers, demonstrating the model's functionality and efficiency.

In-ear ECG Signal Enhancement with Denoising Convolutional Autoencoders

The cardiac dipole has been shown to propagate to the ears, now a common site for consumer wearable electronics, enabling the recording of electrocardiogram (ECG) signals. However, in-ear ECG recordings often suffer from significant noise due to their small amplitude and the presence of other physiological signals, such as electroencephalogram (EEG), which complicates the extraction of cardiovascular features. This study addresses this issue by developing a denoising convolutional autoencoder (DCAE) to enhance ECG information from in-ear recordings, producing cleaner ECG outputs. The model is evaluated using a dataset of in-ear ECGs and corresponding clean Lead I ECGs from 45 healthy participants. The results demonstrate a substantial improvement in signal-to-noise ratio (SNR), with a median increase of 5.9 dB. Additionally, the model significantly improved heart rate estimation accuracy, reducing the mean absolute error by almost 70% and increasing R-peak detection precision to a median value of 90%. We also trained and validated the model using a synthetic dataset, generated from real ECG signals, including abnormal cardiac morphologies, corrupted by pink noise. The results obtained show effective removal of noise sources with clinically plausible waveform reconstruction ability.

ECG Signal Denoising Using Multi-scale Patch Embedding and Transformers

Cardiovascular disease is a major life-threatening condition that is commonly monitored using electrocardiogram (ECG) signals. However, these signals are often contaminated by various types of noise at different intensities, significantly interfering with downstream tasks. Therefore, denoising ECG signals and increasing the signal-to-noise ratio is crucial for cardiovascular monitoring. In this paper, we propose a deep learning method that combines a one-dimensional convolutional layer with transformer architecture for denoising ECG signals. The convolutional layer processes the ECG signal by various kernel/patch sizes and generates an embedding called multi-scale patch embedding. The embedding then is used as the input of a transformer network and enhances the capability of the transformer for denoising the ECG signal.

Variational Diffusion Posterior Sampling with Midpoint Guidance

Diffusion models have recently shown considerable potential in solving Bayesian inverse problems when used as priors. However, sampling from the resulting denoising posterior distributions remains a challenge as it involves intractable terms. To tackle this issue, state-of-the-art approaches formulate the problem as that of sampling from a surrogate diffusion model targeting the posterior and decompose its scores into two terms: the prior score and an intractable guidance term. While the former is replaced by the pre-trained score of the considered diffusion model, the guidance term has to be estimated. In this paper, we propose a novel approach that utilises a decomposition of the transitions which, in contrast to previous methods, allows a trade-off between the complexity of the intractable guidance term and that of the prior transitions. We validate the proposed approach through extensive experiments on linear and nonlinear inverse problems, including challenging cases with latent diffusion models as priors, and demonstrate its effectiveness in reconstructing electrocardiogram (ECG) from partial measurements for accurate cardiac diagnosis.

An Efficient Algorithm Based on Wavelet Transform to Reduce Powerline Noise From Electrocardiograms

Nowadays, the electrocardiogram (ECG) is still the most widely used signal for the diagnosis of cardiac pathologies. However, this recording is often disturbed by the powerline interference (PLI), its removal being mandatory to avoid misdiagnosis. Although a broad variety of methods have been proposed for that purpose, often they substantially alter the original signal morphology or are computationally expensive. Hence, the present work introduces a simple and efficient algorithm to suppress the PLI from the ECG. Briefly, the input signal is decomposed into four Wavelet levels and the resulting coefficients are thresholded to remove the PLI estimated from the TQ intervals. The denoised ECG signal is then reconstructed by computing the inverse Wavelet transform. The method has been validated making use of fifty 10-min length clean ECG segments obtained from the MIT BIH Normal Sinus Rhythm database, which were contaminated with a sinusoidal signal of 50 Hz and variable harmonic content. Comparing the original and denoised ECG signals through a signed correlation index, improvements between 10 - 72% have been observed with respect to common adaptive notch filtering, implemented for comparison. These results suggest that the proposed method is featured by an enhanced trade-off between noise reduction and signal morphology preservation.

SDEMG: Score-based Diffusion Model for Surface Electromyographic Signal Denoising

Surface electromyography (sEMG) recordings can be influenced by electrocardiogram (ECG) signals when the muscle being monitored is close to the heart. Several existing methods use signal-processing-based approaches, such as high-pass filter and template subtraction, while some derive mapping functions to restore clean sEMG signals from noisy sEMG (sEMG with ECG interference). Recently, the score-based diffusion model, a renowned generative model, has been introduced to generate high-quality and accurate samples with noisy input data. In this study, we proposed a novel approach, termed SDEMG, as a score-based diffusion model for sEMG signal denoising. To evaluate the proposed SDEMG approach, we conduct experiments to reduce noise in sEMG signals, employing data from an openly accessible source, the Non-Invasive Adaptive Prosthetics database, along with ECG signals from the MIT-BIH Normal Sinus Rhythm Database. The experiment result indicates that SDEMG outperformed comparative methods and produced high-quality sEMG samples. The source code of SDEMG the framework is available at: https://github.com/tonyliu0910/SDEMG

Region-Disentangled Diffusion Model for High-Fidelity PPG-to-ECG Translation

The high prevalence of cardiovascular diseases (CVDs) calls for accessible and cost-effective continuous cardiac monitoring tools. Despite Electrocardiography (ECG) being the gold standard, continuous monitoring remains a challenge, leading to the exploration of Photoplethysmography (PPG), a promising but more basic alternative available in consumer wearables. This notion has recently spurred interest in translating PPG to ECG signals. In this work, we introduce Region-Disentangled Diffusion Model (RDDM), a novel diffusion model designed to capture the complex temporal dynamics of ECG. Traditional Diffusion models like Denoising Diffusion Probabilistic Models (DDPM) face challenges in capturing such nuances due to the indiscriminate noise addition process across the entire signal. Our proposed RDDM overcomes such limitations by incorporating a novel forward process that selectively adds noise to specific regions of interest (ROI) such as QRS complex in ECG signals, and a reverse process that disentangles the denoising of ROI and non-ROI regions. Quantitative experiments demonstrate that RDDM can generate high-fidelity ECG from PPG in as few as 10 diffusion steps, making it highly effective and computationally efficient. Additionally, to rigorously validate the usefulness of the generated ECG signals, we introduce CardioBench, a comprehensive evaluation benchmark for a variety of cardiac-related tasks including heart rate and blood pressure estimation, stress classification, and the detection of atrial fibrillation and diabetes. Our thorough experiments show that RDDM achieves state-of-the-art performance on CardioBench. To the best of our knowledge, RDDM is the first diffusion model for cross-modal signal-to-signal translation in the bio-signal domain.