Agentic Framework for Epidemiological Modeling

Epidemic modeling is essential for public health planning, yet traditional approaches rely on fixed model classes that require manual redesign as pathogens, policies, and scenario assumptions evolve. We introduce EPIAGENT, an agentic framework that automatically synthesizes, calibrates, verifies, and refines epidemiological simulators by modeling disease progression as an iterative program synthesis problem. A central design choice is an explicit epidemiological flow graph intermediate representation that links scenario specifications to model structure and enables strong, modular correctness checks before code is generated. Verified flow graphs are then compiled into mechanistic models supporting interpretable parameter learning under physical and epidemiological constraints. Evaluation on epidemiological scenario case studies demonstrates that EPIAGENT captures complex growth dynamics and produces epidemiologically consistent counterfactual projections across varying vaccination and immune escape assumptions. Our results show that the agentic feedback loop prevents degeneration and significantly accelerates convergence toward valid models by mimicking professional expert workflows.

Enhanced Diagnostic Performance via Large-Resolution Inference Optimization for Pathology Foundation Models

Despite their prominent performance on tasks such as ROI classification and segmentation, many pathology foundation models remain constrained by a specific input size e.g. 224 x 224, creating substantial inefficiencies when applied to whole-slide images (WSIs), which span thousands of resolutions. A naive strategy is to either enlarge inputs or downsample the WSIs. However, enlarging inputs results in prohibitive GPU memory consumption, while downsampling alters the microns-per-pixel resolution and obscures critical morphological details. To overcome these limitations, we propose an space- and time- efficient inference strategy that sparsifies attention using spatially aware neighboring blocks and filters out non-informative tokens through global attention scores. This design substantially reduces GPU memory and runtime during high-resolution WSI inference while preserving and even improving the downstream performance, enabling inference at higher resolutions under the same GPU budget. The experimental results show that our method can achieves up to an 7.67% improvement in the ROI classification and compatible results in segmentation.

Benign Samples Matter! Fine-tuning On Outlier Benign Samples Severely Breaks Safety

Recent studies have uncovered a troubling vulnerability in the fine-tuning stage of large language models (LLMs): even fine-tuning on entirely benign datasets can lead to a significant increase in the harmfulness of LLM outputs. Building on this finding, our red teaming study takes this threat one step further by developing a more effective attack. Specifically, we analyze and identify samples within benign datasets that contribute most to safety degradation, then fine-tune LLMs exclusively on these samples. We approach this problem from an outlier detection perspective and propose Self-Inf-N, to detect and extract outliers for fine-tuning. Our findings reveal that fine-tuning LLMs on 100 outlier samples selected by Self-Inf-N in the benign datasets severely compromises LLM safety alignment. Extensive experiments across seven mainstream LLMs demonstrate that our attack exhibits high transferability across different architectures and remains effective in practical scenarios. Alarmingly, our results indicate that most existing mitigation strategies fail to defend against this attack, underscoring the urgent need for more robust alignment safeguards. Codes are available at https://github.com/GuanZihan/Benign-Samples-Matter.

BalancEdit: Dynamically Balancing the Generality-Locality Trade-off in Multi-modal Model Editing

Large multi-modal models inevitably decay over time as facts change and previously learned information becomes outdated. Traditional approaches such as fine-tuning are often impractical for updating these models due to their size and complexity. Instead, direct knowledge editing within the models presents a more viable solution. Current model editing techniques, however, typically overlook the unique influence ranges of different facts, leading to compromised model performance in terms of both generality and locality. To address this issue, we introduce the concept of the generality-locality trade-off in multi-modal model editing. We develop a new model editing dataset named OKEDIT, specifically designed to effectively evaluate this trade-off. Building on this foundation, we propose BalancEdit, a novel method for balanced model editing that dynamically achieves an optimal balance between generality and locality. BalancEdit utilizes a unique mechanism that generates both positive and negative samples for each fact to accurately determine its influence scope and incorporates these insights into the model's latent space using a discrete, localized codebook of edits, without modifying the underlying model weights. To our knowledge, this is the first approach explicitly addressing the generality-locality trade-off in multi-modal model editing. Our comprehensive results confirm the effectiveness of BalancEdit, demonstrating minimal trade-offs while maintaining robust editing capabilities. Our code and dataset will be available.

Backdoor in Seconds: Unlocking Vulnerabilities in Large Pre-trained Models via Model Editing

Large pre-trained models have achieved notable success across a range of downstream tasks. However, recent research shows that a type of adversarial attack ($\textit{i.e.,}$ backdoor attack) can manipulate the behavior of machine learning models through contaminating their training dataset, posing significant threat in the real-world application of large pre-trained model, especially for those customized models. Therefore, addressing the unique challenges for exploring vulnerability of pre-trained models is of paramount importance. Through empirical studies on the capability for performing backdoor attack in large pre-trained models ($\textit{e.g.,}$ ViT), we find the following unique challenges of attacking large pre-trained models: 1) the inability to manipulate or even access large training datasets, and 2) the substantial computational resources required for training or fine-tuning these models. To address these challenges, we establish new standards for an effective and feasible backdoor attack in the context of large pre-trained models. In line with these standards, we introduce our EDT model, an \textbf{E}fficient, \textbf{D}ata-free, \textbf{T}raining-free backdoor attack method. Inspired by model editing techniques, EDT injects an editing-based lightweight codebook into the backdoor of large pre-trained models, which replaces the embedding of the poisoned image with the target image without poisoning the training dataset or training the victim model. Our experiments, conducted across various pre-trained models such as ViT, CLIP, BLIP, and stable diffusion, and on downstream tasks including image classification, image captioning, and image generation, demonstrate the effectiveness of our method. Our code is available in the supplementary material.

No Free Lunch: Retrieval-Augmented Generation Undermines Fairness in LLMs, Even for Vigilant Users

Retrieval-Augmented Generation (RAG) is widely adopted for its effectiveness and cost-efficiency in mitigating hallucinations and enhancing the domain-specific generation capabilities of large language models (LLMs). However, is this effectiveness and cost-efficiency truly a free lunch? In this study, we comprehensively investigate the fairness costs associated with RAG by proposing a practical three-level threat model from the perspective of user awareness of fairness. Specifically, varying levels of user fairness awareness result in different degrees of fairness censorship on the external dataset. We examine the fairness implications of RAG using uncensored, partially censored, and fully censored datasets. Our experiments demonstrate that fairness alignment can be easily undermined through RAG without the need for fine-tuning or retraining. Even with fully censored and supposedly unbiased external datasets, RAG can lead to biased outputs. Our findings underscore the limitations of current alignment methods in the context of RAG-based LLMs and highlight the urgent need for new strategies to ensure fairness. We propose potential mitigations and call for further research to develop robust fairness safeguards in RAG-based LLMs.

UFID: A Unified Framework for Input-level Backdoor Detection on Diffusion Models

Diffusion Models are vulnerable to backdoor attacks, where malicious attackers inject backdoors by poisoning some parts of the training samples during the training stage. This poses a serious threat to the downstream users, who query the diffusion models through the API or directly download them from the internet. To mitigate the threat of backdoor attacks, there have been a plethora of investigations on backdoor detections. However, none of them designed a specialized backdoor detection method for diffusion models, rendering the area much under-explored. Moreover, these prior methods mainly focus on the traditional neural networks in the classification task, which cannot be adapted to the backdoor detections on the generative task easily. Additionally, most of the prior methods require white-box access to model weights and architectures, or the probability logits as additional information, which are not always practical. In this paper, we propose a Unified Framework for Input-level backdoor Detection (UFID) on the diffusion models, which is motivated by observations in the diffusion models and further validated with a theoretical causality analysis. Extensive experiments across different datasets on both conditional and unconditional diffusion models show that our method achieves a superb performance on detection effectiveness and run-time efficiency. The code is available at https://github.com/GuanZihan/official_UFID.

Img2Loc: Revisiting Image Geolocalization using Multi-modality Foundation Models and Image-based Retrieval-Augmented Generation

Geolocating precise locations from images presents a challenging problem in computer vision and information retrieval.Traditional methods typically employ either classification, which dividing the Earth surface into grid cells and classifying images accordingly, or retrieval, which identifying locations by matching images with a database of image-location pairs. However, classification-based approaches are limited by the cell size and cannot yield precise predictions, while retrieval-based systems usually suffer from poor search quality and inadequate coverage of the global landscape at varied scale and aggregation levels. To overcome these drawbacks, we present Img2Loc, a novel system that redefines image geolocalization as a text generation task. This is achieved using cutting-edge large multi-modality models like GPT4V or LLaVA with retrieval augmented generation. Img2Loc first employs CLIP-based representations to generate an image-based coordinate query database. It then uniquely combines query results with images itself, forming elaborate prompts customized for LMMs. When tested on benchmark datasets such as Im2GPS3k and YFCC4k, Img2Loc not only surpasses the performance of previous state-of-the-art models but does so without any model training.

XGBD: Explanation-Guided Graph Backdoor Detection

Backdoor attacks pose a significant security risk to graph learning models. Backdoors can be embedded into the target model by inserting backdoor triggers into the training dataset, causing the model to make incorrect predictions when the trigger is present. To counter backdoor attacks, backdoor detection has been proposed. An emerging detection strategy in the vision and NLP domains is based on an intriguing phenomenon: when training models on a mixture of backdoor and clean samples, the loss on backdoor samples drops significantly faster than on clean samples, allowing backdoor samples to be easily detected by selecting samples with the lowest loss values. However, the ignorance of topological feature information on graph data limits its detection effectiveness when applied directly to the graph domain. To this end, we propose an explanation-guided backdoor detection method to take advantage of the topological information. Specifically, we train a helper model on the graph dataset, feed graph samples into the model, and then adopt explanation methods to attribute model prediction to an important subgraph. We observe that backdoor samples have distinct attribution distribution than clean samples, so the explanatory subgraph could serve as more discriminative features for detecting backdoor samples. Comprehensive experiments on multiple popular datasets and attack methods demonstrate the effectiveness and explainability of our method. Our code is available: https://github.com/GuanZihan/GNN_backdoor_detection.

CohortGPT: An Enhanced GPT for Participant Recruitment in Clinical Study

Participant recruitment based on unstructured medical texts such as clinical notes and radiology reports has been a challenging yet important task for the cohort establishment in clinical research. Recently, Large Language Models (LLMs) such as ChatGPT have achieved tremendous success in various downstream tasks thanks to their promising performance in language understanding, inference, and generation. It is then natural to test their feasibility in solving the cohort recruitment task, which involves the classification of a given paragraph of medical text into disease label(s). However, when applied to knowledge-intensive problem settings such as medical text classification, where the LLMs are expected to understand the decision made by human experts and accurately identify the implied disease labels, the LLMs show a mediocre performance. A possible explanation is that, by only using the medical text, the LLMs neglect to use the rich context of additional information that languages afford. To this end, we propose to use a knowledge graph as auxiliary information to guide the LLMs in making predictions. Moreover, to further boost the LLMs adapt to the problem setting, we apply a chain-of-thought (CoT) sample selection strategy enhanced by reinforcement learning, which selects a set of CoT samples given each individual medical report. Experimental results and various ablation studies show that our few-shot learning method achieves satisfactory performance compared with fine-tuning strategies and gains superb advantages when the available data is limited. The code and sample dataset of the proposed CohortGPT model is available at: https://anonymous.4open.science/r/CohortGPT-4872/