M2GNN: Metapath and Multi-interest Aggregated Graph Neural Network for Tag-based Cross-domain Recommendation

Cross-domain recommendation (CDR) is an effective way to alleviate the data sparsity problem. Content-based CDR is one of the most promising branches since most kinds of products can be described by a piece of text, especially when cold-start users or items have few interactions. However, two vital issues are still under-explored: (1) From the content modeling perspective, sufficient long-text descriptions are usually scarce in a real recommender system, more often the light-weight textual features, such as a few keywords or tags, are more accessible, which is improperly modeled by existing methods. (2) From the CDR perspective, not all inter-domain interests are helpful to infer intra-domain interests. Caused by domain-specific features, there are part of signals benefiting for recommendation in the source domain but harmful for that in the target domain. Therefore, how to distill useful interests is crucial. To tackle the above two problems, we propose a metapath and multi-interest aggregated graph neural network (M2GNN). Specifically, to model the tag-based contents, we construct a heterogeneous information network to hold the semantic relatedness between users, items, and tags in all domains. The metapath schema is predefined according to domain-specific knowledge, with one metapath for one domain. User representations are learned by GNN with a hierarchical aggregation framework, where the intra-metapath aggregation firstly filters out trivial tags and the inter-metapath aggregation further filters out useless interests. Offline experiments and online A/B tests demonstrate that M2GNN achieves significant improvements over the state-of-the-art methods and current industrial recommender system in Dianping, respectively. Further analysis shows that M2GNN offers an interpretable recommendation.

Fully Automated Deep Learning-enabled Detection for Hepatic Steatosis on Computed Tomography: A Multicenter International Validation Study

Despite high global prevalence of hepatic steatosis, no automated diagnostics demonstrated generalizability in detecting steatosis on multiple international datasets. Traditionally, hepatic steatosis detection relies on clinicians selecting the region of interest (ROI) on computed tomography (CT) to measure liver attenuation. ROI selection demands time and expertise, and therefore is not routinely performed in populations. To automate the process, we validated an existing artificial intelligence (AI) system for 3D liver segmentation and used it to purpose a novel method: AI-ROI, which could automatically select the ROI for attenuation measurements. AI segmentation and AI-ROI method were evaluated on 1,014 non-contrast enhanced chest CT images from eight international datasets: LIDC-IDRI, NSCLC-Lung1, RIDER, VESSEL12, RICORD-1A, RICORD-1B, COVID-19-Italy, and COVID-19-China. AI segmentation achieved a mean dice coefficient of 0.957. Attenuations measured by AI-ROI showed no significant differences (p = 0.545) and a reduction of 71% time compared to expert measurements. The area under the curve (AUC) of the steatosis classification of AI-ROI is 0.921 (95% CI: 0.883 - 0.959). If performed as a routine screening method, our AI protocol could potentially allow early non-invasive, non-pharmacological preventative interventions for hepatic steatosis. 1,014 expert-annotated liver segmentations of patients with hepatic steatosis annotations can be downloaded here: https://drive.google.com/drive/folders/1-g_zJeAaZXYXGqL1OeF6pUjr6KB0igJX.

Deep learning-based detection of intravenous contrast in computed tomography scans

Purpose: Identifying intravenous (IV) contrast use within CT scans is a key component of data curation for model development and testing. Currently, IV contrast is poorly documented in imaging metadata and necessitates manual correction and annotation by clinician experts, presenting a major barrier to imaging analyses and algorithm deployment. We sought to develop and validate a convolutional neural network (CNN)-based deep learning (DL) platform to identify IV contrast within CT scans. Methods: For model development and evaluation, we used independent datasets of CT scans of head, neck (HN) and lung cancer patients, totaling 133,480 axial 2D scan slices from 1,979 CT scans manually annotated for contrast presence by clinical experts. Five different DL models were adopted and trained in HN training datasets for slice-level contrast detection. Model performances were evaluated on a hold-out set and on an independent validation set from another institution. DL models was then fine-tuned on chest CT data and externally validated on a separate chest CT dataset. Results: Initial DICOM metadata tags for IV contrast were missing or erroneous in 1,496 scans (75.6%). The EfficientNetB4-based model showed the best overall detection performance. For HN scans, AUC was 0.996 in the internal validation set (n = 216) and 1.0 in the external validation set (n = 595). The fine-tuned model on chest CTs yielded an AUC: 1.0 for the internal validation set (n = 53), and AUC: 0.980 for the external validation set (n = 402). Conclusion: The DL model could accurately detect IV contrast in both HN and chest CT scans with near-perfect performance.