Tactile: Giving Computer-Using Agents Hands and Feet

Computer-use agents are becoming capable software operators, but their interface to desktop applications is still often a brittle motor layer: they look at screenshots, predict coordinates, click, and hope that the visible state changed as intended. This collapses target grounding, action execution, and outcome verification into a single ambiguous operation. We present Tactile, an open-source tool layer that gives agents a more reliable "hands and feet" for desktop use. Tactile converts heterogeneous UI evidence--operating-system accessibility semantics, OCR-grounded text, and visual fallback regions--into action-grounded interface states: compact target candidates with source labels, roles or text, state, geometry, executable affordances, and verification cues. Agents operate through an observe-ground-act-verify loop that prefers native semantic actions when available, falls back to OCR-grounded coordinates when visible text is the best evidence, and keeps full provenance for replay and failure attribution. On macOSWorld-style tasks, adding Tactile improves Codex Success@100 from 41.1% to 50.0% overall and from 45.2% to 55.3% on accessibility-adapted tasks; a 96-task cross-agent subset shows consistent gains across Codex, Claude Code, OpenCode, and Goose. These results suggest that reliable computer use requires not only stronger models, but also a reusable execution substrate that exposes software actions as semantic, verifiable, and auditable objects rather than anonymous screen coordinates.

DiffSpectra: Molecular Structure Elucidation from Spectra using Diffusion Models

Molecular structure elucidation from spectra is a foundational problem in chemistry, with profound implications for compound identification, synthesis, and drug development. Traditional methods rely heavily on expert interpretation and lack scalability. Pioneering machine learning methods have introduced retrieval-based strategies, but their reliance on finite libraries limits generalization to novel molecules. Generative models offer a promising alternative, yet most adopt autoregressive SMILES-based architectures that overlook 3D geometry and struggle to integrate diverse spectral modalities. In this work, we present DiffSpectra, a generative framework that directly infers both 2D and 3D molecular structures from multi-modal spectral data using diffusion models. DiffSpectra formulates structure elucidation as a conditional generation process. Its denoising network is parameterized by Diffusion Molecule Transformer, an SE(3)-equivariant architecture that integrates topological and geometric information. Conditioning is provided by SpecFormer, a transformer-based spectral encoder that captures intra- and inter-spectral dependencies from multi-modal spectra. Extensive experiments demonstrate that DiffSpectra achieves high accuracy in structure elucidation, recovering exact structures with 16.01% top-1 accuracy and 96.86% top-20 accuracy through sampling. The model benefits significantly from 3D geometric modeling, SpecFormer pre-training, and multi-modal conditioning. These results highlight the effectiveness of spectrum-conditioned diffusion modeling in addressing the challenge of molecular structure elucidation. To our knowledge, DiffSpectra is the first framework to unify multi-modal spectral reasoning and joint 2D/3D generative modeling for de novo molecular structure elucidation.