A Physics-Driven Neural Network with Parameter Embedding for Generating Quantitative MR Maps from Weighted Images

We propose a deep learning-based approach that integrates MRI sequence parameters to improve the accuracy and generalizability of quantitative image synthesis from clinical weighted MRI. Our physics-driven neural network embeds MRI sequence parameters -- repetition time (TR), echo time (TE), and inversion time (TI) -- directly into the model via parameter embedding, enabling the network to learn the underlying physical principles of MRI signal formation. The model takes conventional T1-weighted, T2-weighted, and T2-FLAIR images as input and synthesizes T1, T2, and proton density (PD) quantitative maps. Trained on healthy brain MR images, it was evaluated on both internal and external test datasets. The proposed method achieved high performance with PSNR values exceeding 34 dB and SSIM values above 0.92 for all synthesized parameter maps. It outperformed conventional deep learning models in accuracy and robustness, including data with previously unseen brain structures and lesions. Notably, our model accurately synthesized quantitative maps for these unseen pathological regions, highlighting its superior generalization capability. Incorporating MRI sequence parameters via parameter embedding allows the neural network to better learn the physical characteristics of MR signals, significantly enhancing the performance and reliability of quantitative MRI synthesis. This method shows great potential for accelerating qMRI and improving its clinical utility.

ContrastDiagnosis: Enhancing Interpretability in Lung Nodule Diagnosis Using Contrastive Learning

With the ongoing development of deep learning, an increasing number of AI models have surpassed the performance levels of human clinical practitioners. However, the prevalence of AI diagnostic products in actual clinical practice remains significantly lower than desired. One crucial reason for this gap is the so-called `black box' nature of AI models. Clinicians' distrust of black box models has directly hindered the clinical deployment of AI products. To address this challenge, we propose ContrastDiagnosis, a straightforward yet effective interpretable diagnosis framework. This framework is designed to introduce inherent transparency and provide extensive post-hoc explainability for deep learning model, making them more suitable for clinical medical diagnosis. ContrastDiagnosis incorporates a contrastive learning mechanism to provide a case-based reasoning diagnostic rationale, enhancing the model's transparency and also offers post-hoc interpretability by highlighting similar areas. High diagnostic accuracy was achieved with AUC of 0.977 while maintain a high transparency and explainability.