1024-Channel 0.8V 23.9-nW/Channel Event-based Compute In-memory Neural Spike Detector

The increasing data rate has become a major issue confronting next-generation intracortical brain-machine interfaces (iBMIs). The scaling number of recording sites requires complex analog wiring and lead to huge digitization power consumption. Compressive event-based neural frontends have been used in high-density neural implants to support the simultaneous recording of more channels. Event-based frontends (EBF) convert recorded signals into asynchronous digital events via delta modulation and can inherently achieve considerable compression. But EBFs are prone to false events that do not correspond to neural spikes. Spike detection (SPD) is a key process in the iBMI pipeline to detect neural spikes and further reduce the data rate. However, conventional digital SPD suffers from the increasing buffer size and frequent memory access power, and conventional spike emphasizers are not compatible with EBFs. In this work we introduced an event-based spike detection (Ev-SPD) algorithm for scalable compressive EBFs. To implement the algorithm effectively, we proposed a novel low-power 10-T eDRAM-SRAM hybrid random-access memory in-memory computing bitcell for event processing. We fabricated the proposed 1024-channel IMC SPD macro in a 65nm process and tested the macro with both synthetic dataset and Neuropixel recordings. The proposed macro achieved a high spike detection accuracy of 96.06% on a synthetic dataset and 95.08% similarity and 0.05 firing pattern MAE on Neuropixel recordings. Our event-based IMC SPD macro achieved a high per channel spike detection energy efficiency of 23.9 nW per channel and an area efficiency of 375 um^2 per channel. Our work presented a SPD scheme compatible with compressive EBFs for high-density iBMIs, achieving ultra-low power consumption with an IMC architecture while maintaining considerable accuracy.

Event-based Neural Spike Detection Using Spiking Neural Networks for Neuromorphic iBMI Systems

Implantable brain-machine interfaces (iBMIs) are evolving to record from thousands of neurons wirelessly but face challenges in data bandwidth, power consumption, and implant size. We propose a novel Spiking Neural Network Spike Detector (SNN-SPD) that processes event-based neural data generated via delta modulation and pulse count modulation, converting signals into sparse events. By leveraging the temporal dynamics and inherent sparsity of spiking neural networks, our method improves spike detection performance while maintaining low computational overhead suitable for implantable devices. Our experimental results demonstrate that the proposed SNN-SPD achieves an accuracy of 95.72% at high noise levels (standard deviation 0.2), which is about 2% higher than the existing Artificial Neural Network Spike Detector (ANN-SPD). Moreover, SNN-SPD requires only 0.41% of the computation and about 26.62% of the weight parameters compared to ANN-SPD, with zero multiplications. This approach balances efficiency and performance, enabling effective data compression and power savings for next-generation iBMIs.

A Low-Power Spike Detector Using In-Memory Computing for Event-based Neural Frontend

With the sensor scaling of next-generation Brain-Machine Interface (BMI) systems, the massive A/D conversion and analog multiplexing at the neural frontend poses a challenge in terms of power and data rates for wireless and implantable BMIs. While previous works have reported the neuromorphic compression of neural signal, further compression requires integration of spike detectors on chip. In this work, we propose an efficient HRAM-based spike detector using In-memory computing for compressive event-based neural frontend. Our proposed method involves detecting spikes from event pulses without reconstructing the signal and uses a 10T hybrid in-memory computing bitcell for the accumulation and thresholding operations. We show that our method ensures a spike detection accuracy of 92-99% for neural signal inputs while consuming only 13.8 nW per channel in 65 nm CMOS.