PIE: Simulating Disease Progression via Progressive Image Editing

Disease progression simulation is a crucial area of research that has significant implications for clinical diagnosis, prognosis, and treatment. One major challenge in this field is the lack of continuous medical imaging monitoring of individual patients over time. To address this issue, we develop a novel framework termed Progressive Image Editing (PIE) that enables controlled manipulation of disease-related image features, facilitating precise and realistic disease progression simulation. Specifically, we leverage recent advancements in text-to-image generative models to simulate disease progression accurately and personalize it for each patient. We theoretically analyze the iterative refining process in our framework as a gradient descent with an exponentially decayed learning rate. To validate our framework, we conduct experiments in three medical imaging domains. Our results demonstrate the superiority of PIE over existing methods such as Stable Diffusion Walk and Style-Based Manifold Extrapolation based on CLIP score (Realism) and Disease Classification Confidence (Alignment). Our user study collected feedback from 35 veteran physicians to assess the generated progressions. Remarkably, 76.2% of the feedback agrees with the fidelity of the generated progressions. To our best knowledge, PIE is the first of its kind to generate disease progression images meeting real-world standards. It is a promising tool for medical research and clinical practice, potentially allowing healthcare providers to model disease trajectories over time, predict future treatment responses, and improve patient outcomes.

Q-ASR: Integer-only Zero-shot Quantization for Efficient Speech Recognition

End-to-end neural network models achieve improved performance on various automatic speech recognition (ASR) tasks. However, these models perform poorly on edge hardware due to large memory and computation requirements. While quantizing model weights and/or activations to low-precision can be a promising solution, previous research on quantizing ASR models is limited. Most quantization approaches use floating-point arithmetic during inference; and thus they cannot fully exploit integer processing units, which use less power than their floating-point counterparts. Moreover, they require training/validation data during quantization for finetuning or calibration; however, this data may not be available due to security/privacy concerns. To address these limitations, we propose Q-ASR, an integer-only, zero-shot quantization scheme for ASR models. In particular, we generate synthetic data whose runtime statistics resemble the real data, and we use it to calibrate models during quantization. We then apply Q-ASR to quantize QuartzNet-15x5 and JasperDR-10x5 without any training data, and we show negligible WER change as compared to the full-precision baseline models. For INT8-only quantization, we observe a very modest WER degradation of up to 0.29%, while we achieve up to 2.44x speedup on a T4 GPU. Furthermore, Q-ASR exhibits a large compression rate of more than 4x with small WER degradation.