Triple-Phase Multimodal Knowledge Aggregation Framework for Microbial Keratitis Subtype Diagnosis on Slit-Lamp Photography

Microbial keratitis requires rapid pathogen identification to guide treatment, but culture- and PCR-based diagnostics are slow and resource-intensive. We developed a triple-phase multimodal framework for bacterial-versus-fungal keratitis classification using slit-lamp photographs acquired under blue-light, sclerotic-scatter, and white-light illumination, together with clinical metadata. The model combines cross-modality contrastive learning, modality-specific fine-tuning, and feature-level multimodal ensemble learning for patient-level prediction. We evaluated the framework on a multicenter dataset of 1,645 patients and 17,158 images from India and the United States. The model achieved 85.84% accuracy, 84.46% average F1-score, and 0.885 AUC. Site-specific evaluation showed that pooled results were overly optimistic, whereas resampling- and balance-based re-evaluation provided a more realistic assessment of cross-site generalization. Under all settings, our framework remained the top-performing approach. Upon acceptance, the code will be released and dataset access will be provided subject to University of Michigan data-sharing clearance.

Beyond Ground-Truth: Leveraging Image Quality Priors for Real-World Image Restoration

Real-world image restoration aims to restore high-quality (HQ) images from degraded low-quality (LQ) inputs captured under uncontrolled conditions. Existing methods typically depend on ground-truth (GT) supervision, assuming that GT provides perfect reference quality. However, GT can still contain images with inconsistent perceptual fidelity, causing models to converge to the average quality level of the training data rather than achieving the highest perceptual quality attainable. To address these problems, we propose a novel framework, termed IQPIR, that introduces an Image Quality Prior (IQP)-extracted from pre-trained No-Reference Image Quality Assessment (NR-IQA) models-to guide the restoration process toward perceptually optimal outputs explicitly. Our approach synergistically integrates IQP with a learned codebook prior through three key mechanisms: (1) a quality-conditioned Transformer, where NR-IQA-derived scores serve as conditioning signals to steer the predicted representation toward maximal perceptual quality. This design provides a plug-and-play enhancement compatible with existing restoration architectures without structural modification; and (2) a dual-branch codebook structure, which disentangles common and HQ-specific features, ensuring a comprehensive representation of both generic structural information and quality-sensitive attributes; and (3) a discrete representation-based quality optimization strategy, which mitigates over-optimization effects commonly observed in continuous latent spaces. Extensive experiments on real-world image restoration demonstrate that our method not only surpasses cutting-edge methods but also serves as a generalizable quality-guided enhancement strategy for existing methods. The code is available.

QualiTeacher: Quality-Conditioned Pseudo-Labeling for Real-World Image Restoration

Real-world image restoration (RWIR) is a highly challenging task due to the absence of clean ground-truth images. Many recent methods resort to pseudo-label (PL) supervision, often within a Mean-Teacher (MT) framework. However, these methods face a critical paradox: unconditionally trusting the often imperfect, low-quality PLs forces the student model to learn undesirable artifacts, while discarding them severely limits data diversity and impairs model generalization. In this paper, we propose QualiTeacher, a novel framework that transforms pseudo-label quality from a noisy liability into a conditional supervisory signal. Instead of filtering, QualiTeacher explicitly conditions the student model on the quality of the PLs, estimated by an ensemble of complementary non-reference image quality assessment (NR-IQA) models spanning low-level distortion and semantic-level assessment. This strategy teaches the student network to learn a quality-graded restoration manifold, enabling it to understand what constitutes different quality levels. Consequently, it can not only avoid mimicking artifacts from low-quality labels but also extrapolate to generate results of higher quality than the teacher itself. To ensure the robustness and accuracy of this quality-driven learning, we further enhance the process with a multi-augmentation scheme to diversify the PL quality spectrum, a score-based preference optimization strategy inspired by Direct Preference Optimization (DPO) to enforce a monotonically ordered quality separation, and a cropped consistency loss to prevent adversarial over-optimization (reward hacking) of the IQA models. Experiments on standard RWIR benchmarks demonstrate that QualiTeacher can serve as a plug-and-play strategy to improve the quality of the existing pseudo-labeling framework, establishing a new paradigm for learning from imperfect supervision. Code will be released.

PRIMA: Pre-training with Risk-integrated Image-Metadata Alignment for Medical Diagnosis via LLM

Medical diagnosis requires the effective synthesis of visual manifestations and clinical metadata. However, existing methods often treat metadata as isolated tags, failing to exploit the rich semantic knowledge embedded in clinical descriptions. We propose PRIMA (Pre-training with Risk-integrated Image-Metadata Alignment), a framework that integrates domain-specific knowledge into multi-modal representation learning. We first curate an expert corpus of risk-disease correlations via Retrieval-Augmented Generation (RAG) to refine Clinical ModernBERT, embedding diagnostic priors into the text encoder. To bridge the modality gap, we introduce a dual-encoder pre-training strategy utilizing DINOv3 and our refined BERT, optimized by a suite of four complementary loss functions. These losses are designed to capture multi-granular semantic alignment and handle the ambiguity of clinical correlations through soft labels. Finally, we leverage Qwen-3 to fuse these aligned features for precise disease classification. Extensive experiments demonstrate that PRIMA effectively harmonizes pixel-level features with abstract clinical expertise, significantly outperforming other state-of-the-art methods. Notably, our framework achieves superior robustness without the need for massive data collection or exhaustive computational resources. Our code will be made public upon acceptance.

Refining Context-Entangled Content Segmentation via Curriculum Selection and Anti-Curriculum Promotion

Biological learning proceeds from easy to difficult tasks, gradually reinforcing perception and robustness. Inspired by this principle, we address Context-Entangled Content Segmentation (CECS), a challenging setting where objects share intrinsic visual patterns with their surroundings, as in camouflaged object detection. Conventional segmentation networks predominantly rely on architectural enhancements but often ignore the learning dynamics that govern robustness under entangled data distributions. We introduce CurriSeg, a dual-phase learning framework that unifies curriculum and anti-curriculum principles to improve representation reliability. In the Curriculum Selection phase, CurriSeg dynamically selects training data based on the temporal statistics of sample losses, distinguishing hard-but-informative samples from noisy or ambiguous ones, thus enabling stable capability enhancement. In the Anti-Curriculum Promotion phase, we design Spectral-Blindness Fine-Tuning, which suppresses high-frequency components to enforce dependence on low-frequency structural and contextual cues and thus strengthens generalization. Extensive experiments demonstrate that CurriSeg achieves consistent improvements across diverse CECS benchmarks without adding parameters or increasing total training time, offering a principled view of how progression and challenge interplay to foster robust and context-aware segmentation. Code will be released.

Reversible Unfolding Network for Concealed Visual Perception with Generative Refinement

Existing methods for concealed visual perception (CVP) often leverage reversible strategies to decrease uncertainty, yet these are typically confined to the mask domain, leaving the potential of the RGB domain underexplored. To address this, we propose a reversible unfolding network with generative refinement, termed RUN++. Specifically, RUN++ first formulates the CVP task as a mathematical optimization problem and unfolds the iterative solution into a multi-stage deep network. This approach provides a principled way to apply reversible modeling across both mask and RGB domains while leveraging a diffusion model to resolve the resulting uncertainty. Each stage of the network integrates three purpose-driven modules: a Concealed Object Region Extraction (CORE) module applies reversible modeling to the mask domain to identify core object regions; a Context-Aware Region Enhancement (CARE) module extends this principle to the RGB domain to foster better foreground-background separation; and a Finetuning Iteration via Noise-based Enhancement (FINE) module provides a final refinement. The FINE module introduces a targeted Bernoulli diffusion model that refines only the uncertain regions of the segmentation mask, harnessing the generative power of diffusion for fine-detail restoration without the prohibitive computational cost of a full-image process. This unique synergy, where the unfolding network provides a strong uncertainty prior for the diffusion model, allows RUN++ to efficiently direct its focus toward ambiguous areas, significantly mitigating false positives and negatives. Furthermore, we introduce a new paradigm for building robust CVP systems that remain effective under real-world degradations and extend this concept into a broader bi-level optimization framework.

Segment Concealed Objects with Incomplete Supervision

Incompletely-Supervised Concealed Object Segmentation (ISCOS) involves segmenting objects that seamlessly blend into their surrounding environments, utilizing incompletely annotated data, such as weak and semi-annotations, for model training. This task remains highly challenging due to (1) the limited supervision provided by the incompletely annotated training data, and (2) the difficulty of distinguishing concealed objects from the background, which arises from the intrinsic similarities in concealed scenarios. In this paper, we introduce the first unified method for ISCOS to address these challenges. To tackle the issue of incomplete supervision, we propose a unified mean-teacher framework, SEE, that leverages the vision foundation model, ``\emph{Segment Anything Model (SAM)}'', to generate pseudo-labels using coarse masks produced by the teacher model as prompts. To mitigate the effect of low-quality segmentation masks, we introduce a series of strategies for pseudo-label generation, storage, and supervision. These strategies aim to produce informative pseudo-labels, store the best pseudo-labels generated, and select the most reliable components to guide the student model, thereby ensuring robust network training. Additionally, to tackle the issue of intrinsic similarity, we design a hybrid-granularity feature grouping module that groups features at different granularities and aggregates these results. By clustering similar features, this module promotes segmentation coherence, facilitating more complete segmentation for both single-object and multiple-object images. We validate the effectiveness of our approach across multiple ISCOS tasks, and experimental results demonstrate that our method achieves state-of-the-art performance. Furthermore, SEE can serve as a plug-and-play solution, enhancing the performance of existing models.

UnfoldIR: Rethinking Deep Unfolding Network in Illumination Degradation Image Restoration

Deep unfolding networks (DUNs) are widely employed in illumination degradation image restoration (IDIR) to merge the interpretability of model-based approaches with the generalization of learning-based methods. However, the performance of DUN-based methods remains considerably inferior to that of state-of-the-art IDIR solvers. Our investigation indicates that this limitation does not stem from structural shortcomings of DUNs but rather from the limited exploration of the unfolding structure, particularly for (1) constructing task-specific restoration models, (2) integrating advanced network architectures, and (3) designing DUN-specific loss functions. To address these issues, we propose a novel DUN-based method, UnfoldIR, for IDIR tasks. UnfoldIR first introduces a new IDIR model with dedicated regularization terms for smoothing illumination and enhancing texture. We unfold the iterative optimized solution of this model into a multistage network, with each stage comprising a reflectance-assisted illumination correction (RAIC) module and an illumination-guided reflectance enhancement (IGRE) module. RAIC employs a visual state space (VSS) to extract non-local features, enforcing illumination smoothness, while IGRE introduces a frequency-aware VSS to globally align similar textures, enabling mildly degraded regions to guide the enhancement of details in more severely degraded areas. This suppresses noise while enhancing details. Furthermore, given the multistage structure, we propose an inter-stage information consistent loss to maintain network stability in the final stages. This loss contributes to structural preservation and sustains the model's performance even in unsupervised settings. Experiments verify our effectiveness across 5 IDIR tasks and 3 downstream problems.

IQPFR: An Image Quality Prior for Blind Face Restoration and Beyond

Blind Face Restoration (BFR) addresses the challenge of reconstructing degraded low-quality (LQ) facial images into high-quality (HQ) outputs. Conventional approaches predominantly rely on learning feature representations from ground-truth (GT) data; however, inherent imperfections in GT datasets constrain restoration performance to the mean quality level of the training data, rather than attaining maximally attainable visual quality. To overcome this limitation, we propose a novel framework that incorporates an Image Quality Prior (IQP) derived from No-Reference Image Quality Assessment (NR-IQA) models to guide the restoration process toward optimal HQ reconstructions. Our methodology synergizes this IQP with a learned codebook prior through two critical innovations: (1) During codebook learning, we devise a dual-branch codebook architecture that disentangles feature extraction into universal structural components and HQ-specific attributes, ensuring comprehensive representation of both common and high-quality facial characteristics. (2) In the codebook lookup stage, we implement a quality-conditioned Transformer-based framework. NR-IQA-derived quality scores act as dynamic conditioning signals to steer restoration toward the highest feasible quality standard. This score-conditioned paradigm enables plug-and-play enhancement of existing BFR architectures without modifying the original structure. We also formulate a discrete representation-based quality optimization strategy that circumvents over-optimization artifacts prevalent in continuous latent space approaches. Extensive experiments demonstrate that our method outperforms state-of-the-art techniques across multiple benchmarks. Besides, our quality-conditioned framework demonstrates consistent performance improvements when integrated with prior BFR models. The code will be released.

RUN: Reversible Unfolding Network for Concealed Object Segmentation

Existing concealed object segmentation (COS) methods frequently utilize reversible strategies to address uncertain regions. However, these approaches are typically restricted to the mask domain, leaving the potential of the RGB domain underexplored. To address this, we propose the Reversible Unfolding Network (RUN), which applies reversible strategies across both mask and RGB domains through a theoretically grounded framework, enabling accurate segmentation. RUN first formulates a novel COS model by incorporating an extra residual sparsity constraint to minimize segmentation uncertainties. The iterative optimization steps of the proposed model are then unfolded into a multistage network, with each step corresponding to a stage. Each stage of RUN consists of two reversible modules: the Segmentation-Oriented Foreground Separation (SOFS) module and the Reconstruction-Oriented Background Extraction (ROBE) module. SOFS applies the reversible strategy at the mask level and introduces Reversible State Space to capture non-local information. ROBE extends this to the RGB domain, employing a reconstruction network to address conflicting foreground and background regions identified as distortion-prone areas, which arise from their separate estimation by independent modules. As the stages progress, RUN gradually facilitates reversible modeling of foreground and background in both the mask and RGB domains, directing the network's attention to uncertain regions and mitigating false-positive and false-negative results. Extensive experiments demonstrate the superior performance of RUN and highlight the potential of unfolding-based frameworks for COS and other high-level vision tasks. We will release the code and models.