SynthBA: Reliable Brain Age Estimation Across Multiple MRI Sequences and Resolutions

Brain age is a critical measure that reflects the biological ageing process of the brain. The gap between brain age and chronological age, referred to as brain PAD (Predicted Age Difference), has been utilized to investigate neurodegenerative conditions. Brain age can be predicted using MRIs and machine learning techniques. However, existing methods are often sensitive to acquisition-related variabilities, such as differences in acquisition protocols, scanners, MRI sequences, and resolutions, significantly limiting their application in highly heterogeneous clinical settings. In this study, we introduce Synthetic Brain Age (SynthBA), a robust deep-learning model designed for predicting brain age. SynthBA utilizes an advanced domain randomization technique, ensuring effective operation across a wide array of acquisition-related variabilities. To assess the effectiveness and robustness of SynthBA, we evaluate its predictive capabilities on internal and external datasets, encompassing various MRI sequences and resolutions, and compare it with state-of-the-art techniques. Additionally, we calculate the brain PAD in a large cohort of subjects with Alzheimer's Disease (AD), demonstrating a significant correlation with AD-related measures of cognitive dysfunction. SynthBA holds the potential to facilitate the broader adoption of brain age prediction in clinical settings, where re-training or fine-tuning is often unfeasible. The SynthBA source code and pre-trained models are publicly available at https://github.com/LemuelPuglisi/SynthBA.

PhilHumans: Benchmarking Machine Learning for Personal Health

The use of machine learning in Healthcare has the potential to improve patient outcomes as well as broaden the reach and affordability of Healthcare. The history of other application areas indicates that strong benchmarks are essential for the development of intelligent systems. We present Personal Health Interfaces Leveraging HUman-MAchine Natural interactions (PhilHumans), a holistic suite of benchmarks for machine learning across different Healthcare settings - talk therapy, diet coaching, emergency care, intensive care, obstetric sonography - as well as different learning settings, such as action anticipation, timeseries modeling, insight mining, language modeling, computer vision, reinforcement learning and program synthesis

DeepFeatureX Net: Deep Features eXtractors based Network for discriminating synthetic from real images

Deepfakes, synthetic images generated by deep learning algorithms, represent one of the biggest challenges in the field of Digital Forensics. The scientific community is working to develop approaches that can discriminate the origin of digital images (real or AI-generated). However, these methodologies face the challenge of generalization, that is, the ability to discern the nature of an image even if it is generated by an architecture not seen during training. This usually leads to a drop in performance. In this context, we propose a novel approach based on three blocks called Base Models, each of which is responsible for extracting the discriminative features of a specific image class (Diffusion Model-generated, GAN-generated, or real) as it is trained by exploiting deliberately unbalanced datasets. The features extracted from each block are then concatenated and processed to discriminate the origin of the input image. Experimental results showed that this approach not only demonstrates good robust capabilities to JPEG compression but also outperforms state-of-the-art methods in several generalization tests. Code, models and dataset are available at https://github.com/opontorno/block-based_deepfake-detection.

Uncertainty-guided Open-Set Source-Free Unsupervised Domain Adaptation with Target-private Class Segregation

Standard Unsupervised Domain Adaptation (UDA) aims to transfer knowledge from a labeled source domain to an unlabeled target but usually requires simultaneous access to both source and target data. Moreover, UDA approaches commonly assume that source and target domains share the same labels space. Yet, these two assumptions are hardly satisfied in real-world scenarios. This paper considers the more challenging Source-Free Open-set Domain Adaptation (SF-OSDA) setting, where both assumptions are dropped. We propose a novel approach for SF-OSDA that exploits the granularity of target-private categories by segregating their samples into multiple unknown classes. Starting from an initial clustering-based assignment, our method progressively improves the segregation of target-private samples by refining their pseudo-labels with the guide of an uncertainty-based sample selection module. Additionally, we propose a novel contrastive loss, named NL-InfoNCELoss, that, integrating negative learning into self-supervised contrastive learning, enhances the model robustness to noisy pseudo-labels. Extensive experiments on benchmark datasets demonstrate the superiority of the proposed method over existing approaches, establishing new state-of-the-art performance. Notably, additional analyses show that our method is able to learn the underlying semantics of novel classes, opening the possibility to perform novel class discovery.

On the exploitation of DCT statistics for cropping detectors

{The study of frequency components derived from Discrete Cosine Transform (DCT) has been widely used in image analysis. In recent years it has been observed that significant information can be extrapolated from them about the lifecycle of the image, but no study has focused on the analysis between them and the source resolution of the image. In this work, we investigated a novel image resolution classifier that employs DCT statistics with the goal to detect the original resolution of images; in particular the insight was exploited to address the challenge of identifying cropped images. Training a Machine Learning (ML) classifier on entire images (not cropped), the generated model can leverage this information to detect cropping. The results demonstrate the classifier's reliability in distinguishing between cropped and not cropped images, providing a dependable estimation of their original resolution. This advancement has significant implications for image processing applications, including digital security, authenticity verification, and visual quality analysis, by offering a new tool for detecting image manipulations and enhancing qualitative image assessment. This work opens new perspectives in the field, with potential to transform image analysis and usage across multiple domains.}

On the Exploitation of DCT-Traces in the Generative-AI Domain

Deepfakes represent one of the toughest challenges in the world of Cybersecurity and Digital Forensics, especially considering the high-quality results obtained with recent generative AI-based solutions. Almost all generative models leave unique traces in synthetic data that, if analyzed and identified in detail, can be exploited to improve the generalization limitations of existing deepfake detectors. In this paper we analyzed deepfake images in the frequency domain generated by both GAN and Diffusion Model engines, examining in detail the underlying statistical distribution of Discrete Cosine Transform (DCT) coefficients. Recognizing that not all coefficients contribute equally to image detection, we hypothesize the existence of a unique "discriminative fingerprint", embedded in specific combinations of coefficients. To identify them, Machine Learning classifiers were trained on various combinations of coefficients. In addition, the Explainable AI (XAI) LIME algorithm was used to search for intrinsic discriminative combinations of coefficients. Finally, we performed a robustness test to analyze the persistence of traces by applying JPEG compression. The experimental results reveal the existence of traces left by the generative models that are more discriminative and persistent at JPEG attacks.

MITS-GAN: Safeguarding Medical Imaging from Tampering with Generative Adversarial Networks

The progress in generative models, particularly Generative Adversarial Networks (GANs), opened new possibilities for image generation but raised concerns about potential malicious uses, especially in sensitive areas like medical imaging. This study introduces MITS-GAN, a novel approach to prevent tampering in medical images, with a specific focus on CT scans. The approach disrupts the output of the attacker's CT-GAN architecture by introducing imperceptible but yet precise perturbations. Specifically, the proposed approach involves the introduction of appropriate Gaussian noise to the input as a protective measure against various attacks. Our method aims to enhance tamper resistance, comparing favorably to existing techniques. Experimental results on a CT scan dataset demonstrate MITS-GAN's superior performance, emphasizing its ability to generate tamper-resistant images with negligible artifacts. As image tampering in medical domains poses life-threatening risks, our proactive approach contributes to the responsible and ethical use of generative models. This work provides a foundation for future research in countering cyber threats in medical imaging. Models and codes are publicly available at the following link \url{https://iplab.dmi.unict.it/MITS-GAN-2024/}.

A Novel Dataset for Non-Destructive Inspection of Handwritten Documents

Forensic handwriting examination is a branch of Forensic Science that aims to examine handwritten documents in order to properly define or hypothesize the manuscript's author. These analysis involves comparing two or more (digitized) documents through a comprehensive comparison of intrinsic local and global features. If a correlation exists and specific best practices are satisfied, then it will be possible to affirm that the documents under analysis were written by the same individual. The need to create sophisticated tools capable of extracting and comparing significant features has led to the development of cutting-edge software with almost entirely automated processes, improving the forensic examination of handwriting and achieving increasingly objective evaluations. This is made possible by algorithmic solutions based on purely mathematical concepts. Machine Learning and Deep Learning models trained with specific datasets could turn out to be the key elements to best solve the task at hand. In this paper, we proposed a new and challenging dataset consisting of two subsets: the first consists of 21 documents written either by the classic ``pen and paper" approach (and later digitized) and directly acquired on common devices such as tablets; the second consists of 362 handwritten manuscripts by 124 different people, acquired following a specific pipeline. Our study pioneered a comparison between traditionally handwritten documents and those produced with digital tools (e.g., tablets). Preliminary results on the proposed datasets show that 90% classification accuracy can be achieved on the first subset (documents written on both paper and pen and later digitized and on tablets) and 96% on the second portion of the data. The datasets are available at https://iplab.dmi.unict.it/mfs/forensic-handwriting-analysis/novel-dataset-2023/.

AI Mirage: The Impostor Bias and the Deepfake Detection Challenge in the Era of Artificial Illusions

This paper provides a comprehensive analysis of cognitive biases in forensics and digital forensics, examining their implications for decision-making processes in these fields. It explores the various types of cognitive biases that may arise during forensic investigations and digital forensic analyses, such as confirmation bias, expectation bias, overconfidence in errors, contextual bias, and attributional biases. It also evaluates existing methods and techniques used to mitigate cognitive biases in these contexts, assessing the effectiveness of interventions aimed at reducing biases and improving decision-making outcomes. Additionally, this paper introduces a new cognitive bias, called "impostor bias", that may affect the use of generative Artificial Intelligence (AI) tools in forensics and digital forensics. The impostor bias is the tendency to doubt the authenticity or validity of the output generated by AI tools, such as deepfakes, in the form of audio, images, and videos. This bias may lead to erroneous judgments or false accusations, undermining the reliability and credibility of forensic evidence. The paper discusses the potential causes and consequences of the impostor bias, and suggests some strategies to prevent or counteract it. By addressing these topics, this paper seeks to offer valuable insights into understanding cognitive biases in forensic practices and provide recommendations for future research and practical applications to enhance the objectivity and validity of forensic investigations.

An Innovative Tool for Uploading/Scraping Large Image Datasets on Social Networks

Nowadays, people can retrieve and share digital information in an increasingly easy and fast fashion through the well-known digital platforms, including sensitive data, inappropriate or illegal content, and, in general, information that might serve as probative evidence in court. Consequently, to assess forensics issues, we need to figure out how to trace back to the posting chain of a digital evidence (e.g., a picture, an audio) throughout the involved platforms -- this is what Digital (also Forensics) Ballistics basically deals with. With the entry of Machine Learning as a tool of the trade in many research areas, the need for vast amounts of data has been dramatically increasing over the last few years. However, collecting or simply find the "right" datasets that properly enables data-driven research studies can turn out to be not trivial in some cases, if not extremely challenging, especially when it comes with highly specialized tasks, such as creating datasets analyzed to detect the source media platform of a given digital media. In this paper we propose an automated approach by means of a digital tool that we created on purpose. The tool is capable of automatically uploading an entire image dataset to the desired digital platform and then downloading all the uploaded pictures, thus shortening the overall time required to output the final dataset to be analyzed.