Contrastive Learning on Multimodal Analysis of Electronic Health Records

Electronic health record (EHR) systems contain a wealth of multimodal clinical data including structured data like clinical codes and unstructured data such as clinical notes. However, many existing EHR-focused studies has traditionally either concentrated on an individual modality or merged different modalities in a rather rudimentary fashion. This approach often results in the perception of structured and unstructured data as separate entities, neglecting the inherent synergy between them. Specifically, the two important modalities contain clinically relevant, inextricably linked and complementary health information. A more complete picture of a patient's medical history is captured by the joint analysis of the two modalities of data. Despite the great success of multimodal contrastive learning on vision-language, its potential remains under-explored in the realm of multimodal EHR, particularly in terms of its theoretical understanding. To accommodate the statistical analysis of multimodal EHR data, in this paper, we propose a novel multimodal feature embedding generative model and design a multimodal contrastive loss to obtain the multimodal EHR feature representation. Our theoretical analysis demonstrates the effectiveness of multimodal learning compared to single-modality learning and connects the solution of the loss function to the singular value decomposition of a pointwise mutual information matrix. This connection paves the way for a privacy-preserving algorithm tailored for multimodal EHR feature representation learning. Simulation studies show that the proposed algorithm performs well under a variety of configurations. We further validate the clinical utility of the proposed algorithm in real-world EHR data.

Safeguarding Data in Multimodal AI: A Differentially Private Approach to CLIP Training

The surge in multimodal AI's success has sparked concerns over data privacy in vision-and-language tasks. While CLIP has revolutionized multimodal learning through joint training on images and text, its potential to unintentionally disclose sensitive information necessitates the integration of privacy-preserving mechanisms. We introduce a differentially private adaptation of the Contrastive Language-Image Pretraining (CLIP) model that effectively addresses privacy concerns while retaining accuracy. Our proposed method, Dp-CLIP, is rigorously evaluated on benchmark datasets encompassing diverse vision-and-language tasks such as image classification and visual question answering. We demonstrate that our approach retains performance on par with the standard non-private CLIP model. Furthermore, we analyze our proposed algorithm under linear representation settings. We derive the convergence rate of our algorithm and show a trade-off between utility and privacy when gradients are clipped per-batch and the loss function does not satisfy smoothness conditions assumed in the literature for the analysis of DP-SGD.

Understanding Multimodal Contrastive Learning and Incorporating Unpaired Data

Language-supervised vision models have recently attracted great attention in computer vision. A common approach to build such models is to use contrastive learning on paired data across the two modalities, as exemplified by Contrastive Language-Image Pre-Training (CLIP). In this paper, under linear representation settings, (i) we initiate the investigation of a general class of nonlinear loss functions for multimodal contrastive learning (MMCL) including CLIP loss and show its connection to singular value decomposition (SVD). Namely, we show that each step of loss minimization by gradient descent can be seen as performing SVD on a contrastive cross-covariance matrix. Based on this insight, (ii) we analyze the performance of MMCL. We quantitatively show that the feature learning ability of MMCL can be better than that of unimodal contrastive learning applied to each modality even under the presence of wrongly matched pairs. This characterizes the robustness of MMCL to noisy data. Furthermore, when we have access to additional unpaired data, (iii) we propose a new MMCL loss that incorporates additional unpaired datasets. We show that the algorithm can detect the ground-truth pairs and improve performance by fully exploiting unpaired datasets. The performance of the proposed algorithm was verified by numerical experiments.

The Power of Contrast for Feature Learning: A Theoretical Analysis

Contrastive learning has achieved state-of-the-art performance in various self-supervised learning tasks and even outperforms its supervised counterpart. Despite its empirical success, theoretical understanding of why contrastive learning works is still limited. In this paper, (i) we provably show that contrastive learning outperforms autoencoder, a classical unsupervised learning method, for both feature recovery and downstream tasks; (ii) we also illustrate the role of labeled data in supervised contrastive learning. This provides theoretical support for recent findings that contrastive learning with labels improves the performance of learned representations in the in-domain downstream task, but it can harm the performance in transfer learning. We verify our theory with numerical experiments.

Asymptotic Risk of Overparameterized Likelihood Models: Double Descent Theory for Deep Neural Networks

We investigate the asymptotic risk of a general class of overparameterized likelihood models, including deep models. The recent empirical success of large-scale models has motivated several theoretical studies to investigate a scenario wherein both the number of samples, $n$, and parameters, $p$, diverge to infinity and derive an asymptotic risk at the limit. However, these theorems are only valid for linear-in-feature models, such as generalized linear regression, kernel regression, and shallow neural networks. Hence, it is difficult to investigate a wider class of nonlinear models, including deep neural networks with three or more layers. In this study, we consider a likelihood maximization problem without the model constraints and analyze the upper bound of an asymptotic risk of an estimator with penalization. Technically, we combine a property of the Fisher information matrix with an extended Marchenko-Pastur law and associate the combination with empirical process techniques. The derived bound is general, as it describes both the double descent and the regularized risk curves, depending on the penalization. Our results are valid without the linear-in-feature constraints on models and allow us to derive the general spectral distributions of a Fisher information matrix from the likelihood. We demonstrate that several explicit models, such as parallel deep neural networks, ensemble learning, and residual networks, are in agreement with our theory. This result indicates that even large and deep models have a small asymptotic risk if they exhibit a specific structure, such as divisibility. To verify this finding, we conduct a real-data experiment with parallel deep neural networks. Our results expand the applicability of the asymptotic risk analysis, and may also contribute to the understanding and application of deep learning.

Adaptive Approximation and Estimation of Deep Neural Network to Intrinsic Dimensionality

We theoretically prove that the generalization performance of deep neural networks (DNNs) is mainly determined by an intrinsic low-dimensional structure of data. Recently, DNNs empirically provide outstanding performance in various machine learning applications. Motivated by the success, theoretical properties of DNNs (e.g. a generalization error) are actively investigated by numerous studies toward understanding their mechanism. Especially, how DNNs behave with high-dimensional data is one of the most important concerns. However, the problem is not sufficiently investigated from an aspect of characteristics of data, despite it is frequently observed that high-dimensional data have an intrinsic low-dimensionality in practice. In this paper, to clarify a connection between DNNs and such the data, we derive bounds for approximation and generalization errors by DNNs with intrinsic low-dimensional data. To the end, we introduce a general notion of an intrinsic dimension and develop a novel proof technique to evaluate the errors. Consequently, we show that convergence rates of the errors by DNNs do not depend on the nominal high-dimensionality of data, but depend on the lower intrinsic dimension. We also show that the rate is optimal in the minimax sense. Furthermore, we find that DNNs with increasing layers can handle a broader class of intrinsic low-dimensional data. We conduct a numerical simulation to validate (i) the intrinsic dimension of data affects the generalization error of DNNs, and (ii) DNNs outperform other non-parametric estimators which are also adaptive to the intrinsic dimension.