Towards Artificial Intelligence Research Assistant for Expert-Involved Learning

Large Language Models (LLMs) and Large Multi-Modal Models (LMMs) have emerged as transformative tools in scientific research, yet their reliability and specific contributions to biomedical applications remain insufficiently characterized. In this study, we present \textbf{AR}tificial \textbf{I}ntelligence research assistant for \textbf{E}xpert-involved \textbf{L}earning (ARIEL), a multimodal dataset designed to benchmark and enhance two critical capabilities of LLMs and LMMs in biomedical research: summarizing extensive scientific texts and interpreting complex biomedical figures. To facilitate rigorous assessment, we create two open-source sets comprising biomedical articles and figures with designed questions. We systematically benchmark both open- and closed-source foundation models, incorporating expert-driven human evaluations conducted by doctoral-level experts. Furthermore, we improve model performance through targeted prompt engineering and fine-tuning strategies for summarizing research papers, and apply test-time computational scaling to enhance the reasoning capabilities of LMMs, achieving superior accuracy compared to human-expert corrections. We also explore the potential of using LMM Agents to generate scientific hypotheses from diverse multimodal inputs. Overall, our results delineate clear strengths and highlight significant limitations of current foundation models, providing actionable insights and guiding future advancements in deploying large-scale language and multi-modal models within biomedical research.

Unsupervised Cross-Domain Prerequisite Chain Learning using Variational Graph Autoencoders

Learning prerequisite chains is an essential task for efficiently acquiring knowledge in both known and unknown domains. For example, one may be an expert in the natural language processing (NLP) domain but want to determine the best order to learn new concepts in an unfamiliar Computer Vision domain (CV). Both domains share some common concepts, such as machine learning basics and deep learning models. In this paper, we propose unsupervised cross-domain concept prerequisite chain learning using an optimized variational graph autoencoder. Our model learns to transfer concept prerequisite relations from an information-rich domain (source domain) to an information-poor domain (target domain), substantially surpassing other baseline models. Also, we expand an existing dataset by introducing two new domains: CV and Bioinformatics (BIO). The annotated data and resources, as well as the code, will be made publicly available.