Dynamic Structural Recovery Parameters Enhance Prediction of Visual Outcomes After Macular Hole Surgery

Purpose: To introduce novel dynamic structural parameters and evaluate their integration within a multimodal deep learning (DL) framework for predicting postoperative visual recovery in idiopathic full-thickness macular hole (iFTMH) patients. Methods: We utilized a publicly available longitudinal OCT dataset at five stages (preoperative, 2 weeks, 3 months, 6 months, and 12 months). A stage specific segmentation model delineated related structures, and an automated pipeline extracted quantitative, composite, qualitative, and dynamic features. Binary logistic regression models, constructed with and without dynamic parameters, assessed their incremental predictive value for best-corrected visual acuity (BCVA). A multimodal DL model combining clinical variables, OCT-derived features, and raw OCT images was developed and benchmarked against regression models. Results: The segmentation model achieved high accuracy across all timepoints (mean Dice > 0.89). Univariate and multivariate analyses identified base diameter, ellipsoid zone integrity, and macular hole area as significant BCVA predictors (P < 0.05). Incorporating dynamic recovery rates consistently improved logistic regression AUC, especially at the 3-month follow-up. The multimodal DL model outperformed logistic regression, yielding higher AUCs and overall accuracy at each stage. The difference is as high as 0.12, demonstrating the complementary value of raw image volume and dynamic parameters. Conclusions: Integrating dynamic parameters into the multimodal DL model significantly enhances the accuracy of predictions. This fully automated process therefore represents a promising clinical decision support tool for personalized postoperative management in macular hole surgery.

UOPSL: Unpaired OCT Predilection Sites Learning for Fundus Image Diagnosis Augmentation

Significant advancements in AI-driven multimodal medical image diagnosis have led to substantial improvements in ophthalmic disease identification in recent years. However, acquiring paired multimodal ophthalmic images remains prohibitively expensive. While fundus photography is simple and cost-effective, the limited availability of OCT data and inherent modality imbalance hinder further progress. Conventional approaches that rely solely on fundus or textual features often fail to capture fine-grained spatial information, as each imaging modality provides distinct cues about lesion predilection sites. In this study, we propose a novel unpaired multimodal framework \UOPSL that utilizes extensive OCT-derived spatial priors to dynamically identify predilection sites, enhancing fundus image-based disease recognition. Our approach bridges unpaired fundus and OCTs via extended disease text descriptions. Initially, we employ contrastive learning on a large corpus of unpaired OCT and fundus images while simultaneously learning the predilection sites matrix in the OCT latent space. Through extensive optimization, this matrix captures lesion localization patterns within the OCT feature space. During the fine-tuning or inference phase of the downstream classification task based solely on fundus images, where paired OCT data is unavailable, we eliminate OCT input and utilize the predilection sites matrix to assist in fundus image classification learning. Extensive experiments conducted on 9 diverse datasets across 28 critical categories demonstrate that our framework outperforms existing benchmarks.

CLAPS: A CLIP-Unified Auto-Prompt Segmentation for Multi-Modal Retinal Imaging

Recent advancements in foundation models, such as the Segment Anything Model (SAM), have significantly impacted medical image segmentation, especially in retinal imaging, where precise segmentation is vital for diagnosis. Despite this progress, current methods face critical challenges: 1) modality ambiguity in textual disease descriptions, 2) a continued reliance on manual prompting for SAM-based workflows, and 3) a lack of a unified framework, with most methods being modality- and task-specific. To overcome these hurdles, we propose CLIP-unified Auto-Prompt Segmentation (\CLAPS), a novel method for unified segmentation across diverse tasks and modalities in retinal imaging. Our approach begins by pre-training a CLIP-based image encoder on a large, multi-modal retinal dataset to handle data scarcity and distribution imbalance. We then leverage GroundingDINO to automatically generate spatial bounding box prompts by detecting local lesions. To unify tasks and resolve ambiguity, we use text prompts enhanced with a unique "modality signature" for each imaging modality. Ultimately, these automated textual and spatial prompts guide SAM to execute precise segmentation, creating a fully automated and unified pipeline. Extensive experiments on 12 diverse datasets across 11 critical segmentation categories show that CLAPS achieves performance on par with specialized expert models while surpassing existing benchmarks across most metrics, demonstrating its broad generalizability as a foundation model.

Efficient Event Stream Super-Resolution with Recursive Multi-Branch Fusion

Current Event Stream Super-Resolution (ESR) methods overlook the redundant and complementary information present in positive and negative events within the event stream, employing a direct mixing approach for super-resolution, which may lead to detail loss and inefficiency. To address these issues, we propose an efficient Recursive Multi-Branch Information Fusion Network (RMFNet) that separates positive and negative events for complementary information extraction, followed by mutual supplementation and refinement. Particularly, we introduce Feature Fusion Modules (FFM) and Feature Exchange Modules (FEM). FFM is designed for the fusion of contextual information within neighboring event streams, leveraging the coupling relationship between positive and negative events to alleviate the misleading of noises in the respective branches. FEM efficiently promotes the fusion and exchange of information between positive and negative branches, enabling superior local information enhancement and global information complementation. Experimental results demonstrate that our approach achieves over 17% and 31% improvement on synthetic and real datasets, accompanied by a 2.3X acceleration. Furthermore, we evaluate our method on two downstream event-driven applications, \emph{i.e.}, object recognition and video reconstruction, achieving remarkable results that outperform existing methods. Our code and Supplementary Material are available at https://github.com/Lqm26/RMFNet.

Bilateral Event Mining and Complementary for Event Stream Super-Resolution

Event Stream Super-Resolution (ESR) aims to address the challenge of insufficient spatial resolution in event streams, which holds great significance for the application of event cameras in complex scenarios. Previous works for ESR often process positive and negative events in a mixed paradigm. This paradigm limits their ability to effectively model the unique characteristics of each event and mutually refine each other by considering their correlations. In this paper, we propose a bilateral event mining and complementary network (BMCNet) to fully leverage the potential of each event and capture the shared information to complement each other simultaneously. Specifically, we resort to a two-stream network to accomplish comprehensive mining of each type of events individually. To facilitate the exchange of information between two streams, we propose a bilateral information exchange (BIE) module. This module is layer-wisely embedded between two streams, enabling the effective propagation of hierarchical global information while alleviating the impact of invalid information brought by inherent characteristics of events. The experimental results demonstrate that our approach outperforms the previous state-of-the-art methods in ESR, achieving performance improvements of over 11\% on both real and synthetic datasets. Moreover, our method significantly enhances the performance of event-based downstream tasks such as object recognition and video reconstruction. Our code is available at https://github.com/Lqm26/BMCNet-ESR.