ReconMIL: Synergizing Latent Space Reconstruction with Bi-Stream Mamba for Whole Slide Image Analysis

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with two critical issues. First, directly applying frozen, task-agnostic features often leads to suboptimal separability due to the domain gap with specific histological tasks. Second, relying solely on global aggregators can cause over-smoothing, where sparse but critical diagnostic signals are overshadowed by the dominant background context. In this paper, we present ReconMIL, a novel framework designed to bridge this domain gap and balance global-local feature aggregation. Our approach introduces a Latent Space Reconstruction module that adaptively projects generic features into a compact, task-specific manifold, improving boundary delineation. To prevent information dilution, we develop a bi-stream architecture combining a Mamba-based global stream for contextual priors and a CNN-based local stream to preserve subtle morphological anomalies. A scale-adaptive selection mechanism dynamically fuses these two streams, determining when to rely on overall architecture versus local saliency. Evaluations across multiple diagnostic and survival prediction benchmarks show that ReconMIL consistently outperforms current state-of-the-art methods, effectively localizing fine-grained diagnostic regions while suppressing background noise. Visualization results confirm the models superior ability to localize diagnostic regions by effectively balancing global structure and local granularity.

AsyMoE: Leveraging Modal Asymmetry for Enhanced Expert Specialization in Large Vision-Language Models

Large Vision-Language Models (LVLMs) have demonstrated impressive performance on multimodal tasks through scaled architectures and extensive training. However, existing Mixture of Experts (MoE) approaches face challenges due to the asymmetry between visual and linguistic processing. Visual information is spatially complete, while language requires maintaining sequential context. As a result, MoE models struggle to balance modality-specific features and cross-modal interactions. Through systematic analysis, we observe that language experts in deeper layers progressively lose contextual grounding and rely more on parametric knowledge rather than utilizing the provided visual and linguistic information. To address this, we propose AsyMoE, a novel architecture that models this asymmetry using three specialized expert groups. We design intra-modality experts for modality-specific processing, hyperbolic inter-modality experts for hierarchical cross-modal interactions, and evidence-priority language experts to suppress parametric biases and maintain contextual grounding. Extensive experiments demonstrate that AsyMoE achieves 26.58% and 15.45% accuracy improvements over vanilla MoE and modality-specific MoE respectively, with 25.45% fewer activated parameters than dense models.