Uni-COAL: A Unified Framework for Cross-Modality Synthesis and Super-Resolution of MR Images

Cross-modality synthesis (CMS), super-resolution (SR), and their combination (CMSR) have been extensively studied for magnetic resonance imaging (MRI). Their primary goals are to enhance the imaging quality by synthesizing the desired modality and reducing the slice thickness. Despite the promising synthetic results, these techniques are often tailored to specific tasks, thereby limiting their adaptability to complex clinical scenarios. Therefore, it is crucial to build a unified network that can handle various image synthesis tasks with arbitrary requirements of modality and resolution settings, so that the resources for training and deploying the models can be greatly reduced. However, none of the previous works is capable of performing CMS, SR, and CMSR using a unified network. Moreover, these MRI reconstruction methods often treat alias frequencies improperly, resulting in suboptimal detail restoration. In this paper, we propose a Unified Co-Modulated Alias-free framework (Uni-COAL) to accomplish the aforementioned tasks with a single network. The co-modulation design of the image-conditioned and stochastic attribute representations ensures the consistency between CMS and SR, while simultaneously accommodating arbitrary combinations of input/output modalities and thickness. The generator of Uni-COAL is also designed to be alias-free based on the Shannon-Nyquist signal processing framework, ensuring effective suppression of alias frequencies. Additionally, we leverage the semantic prior of Segment Anything Model (SAM) to guide Uni-COAL, ensuring a more authentic preservation of anatomical structures during synthesis. Experiments on three datasets demonstrate that Uni-COAL outperforms the alternatives in CMS, SR, and CMSR tasks for MR images, which highlights its generalizability to wide-range applications.

AdLER: Adversarial Training with Label Error Rectification for One-Shot Medical Image Segmentation

Accurate automatic segmentation of medical images typically requires large datasets with high-quality annotations, making it less applicable in clinical settings due to limited training data. One-shot segmentation based on learned transformations (OSSLT) has shown promise when labeled data is extremely limited, typically including unsupervised deformable registration, data augmentation with learned registration, and segmentation learned from augmented data. However, current one-shot segmentation methods are challenged by limited data diversity during augmentation, and potential label errors caused by imperfect registration. To address these issues, we propose a novel one-shot medical image segmentation method with adversarial training and label error rectification (AdLER), with the aim of improving the diversity of generated data and correcting label errors to enhance segmentation performance. Specifically, we implement a novel dual consistency constraint to ensure anatomy-aligned registration that lessens registration errors. Furthermore, we develop an adversarial training strategy to augment the atlas image, which ensures both generation diversity and segmentation robustness. We also propose to rectify potential label errors in the augmented atlas images by estimating segmentation uncertainty, which can compensate for the imperfect nature of deformable registration and improve segmentation authenticity. Experiments on the CANDI and ABIDE datasets demonstrate that the proposed AdLER outperforms previous state-of-the-art methods by 0.7% (CANDI), 3.6% (ABIDE "seen"), and 4.9% (ABIDE "unseen") in segmentation based on Dice scores, respectively. The source code will be available at https://github.com/hsiangyuzhao/AdLER.