A Learning-based Framework for Spatial Impulse Response Compensation in 3D Photoacoustic Computed Tomography

Photoacoustic computed tomography (PACT) is a promising imaging modality that combines the advantages of optical contrast with ultrasound detection. Utilizing ultrasound transducers with larger surface areas can improve detection sensitivity. However, when computationally efficient analytic reconstruction methods that neglect the spatial impulse responses (SIRs) of the transducer are employed, the spatial resolution of the reconstructed images will be compromised. Although optimization-based reconstruction methods can explicitly account for SIR effects, their computational cost is generally high, particularly in three-dimensional (3D) applications. To address the need for accurate but rapid 3D PACT image reconstruction, this study presents a framework for establishing a learned SIR compensation method that operates in the data domain. The learned compensation method maps SIR-corrupted PACT measurement data to compensated data that would have been recorded by idealized point-like transducers. Subsequently, the compensated data can be used with a computationally efficient reconstruction method that neglects SIR effects. Two variants of the learned compensation model are investigated that employ a U-Net model and a specifically designed, physics-inspired model, referred to as Deconv-Net. A fast and analytical training data generation procedure is also a component of the presented framework. The framework is rigorously validated in virtual imaging studies, demonstrating resolution improvement and robustness to noise variations, object complexity, and sound speed heterogeneity. When applied to in-vivo breast imaging data, the learned compensation models revealed fine structures that had been obscured by SIR-induced artifacts. To our knowledge, this is the first demonstration of learned SIR compensation in 3D PACT imaging.

AVMeme Exam: A Multimodal Multilingual Multicultural Benchmark for LLMs' Contextual and Cultural Knowledge and Thinking

Internet audio-visual clips convey meaning through time-varying sound and motion, which extend beyond what text alone can represent. To examine whether AI models can understand such signals in human cultural contexts, we introduce AVMeme Exam, a human-curated benchmark of over one thousand iconic Internet sounds and videos spanning speech, songs, music, and sound effects. Each meme is paired with a unique Q&A assessing levels of understanding from surface content to context and emotion to usage and world knowledge, along with metadata such as original year, transcript, summary, and sensitivity. We systematically evaluate state-of-the-art multimodal large language models (MLLMs) alongside human participants using this benchmark. Our results reveal a consistent limitation: current models perform poorly on textless music and sound effects, and struggle to think in context and in culture compared to surface content. These findings highlight a key gap in human-aligned multimodal intelligence and call for models that can perceive contextually and culturally beyond the surface of what they hear and see. Project page: avmemeexam.github.io/public