Gait Characterization in Duchenne Muscular Dystrophy (DMD) Using a Single-Sensor Accelerometer: Classical Machine Learning and Deep Learning Approaches

Differences in gait patterns of children with Duchenne muscular dystrophy (DMD) and typically developing (TD) peers are visible to the eye, but quantification of those differences outside of the gait laboratory has been elusive. We measured vertical, mediolateral, and anteroposterior acceleration using a waist-worn iPhone accelerometer during ambulation across a typical range of velocities. Six TD and six DMD children from 3-15 years of age underwent seven walking/running tasks, including five 25m walk/run tests at a slow walk to running speeds, a 6-minute walk test (6MWT), and a 100-meter-run/walk (100MRW). We extracted temporospatial clinical gait features (CFs) and applied multiple Artificial Intelligence (AI) tools to differentiate between DMD and TD control children using extracted features and raw data. Extracted CFs showed reduced step length and a greater mediolateral component of total power (TP) consistent with shorter strides and Trendelenberg-like gait commonly observed in DMD. AI methods using CFs and raw data varied ineffectiveness at differentiating between DMD and TD controls at different speeds, with an accuracy of some methods exceeding 91%. We demonstrate that by using AI tools with accelerometer data from a consumer-level smartphone, we can identify DMD gait disturbance in toddlers to early teens.

Adaptive Federated Dropout: Improving Communication Efficiency and Generalization for Federated Learning

With more regulations tackling users' privacy-sensitive data protection in recent years, access to such data has become increasingly restricted and controversial. To exploit the wealth of data generated and located at distributed entities such as mobile phones, a revolutionary decentralized machine learning setting, known as Federated Learning, enables multiple clients located at different geographical locations to collaboratively learn a machine learning model while keeping all their data on-device. However, the scale and decentralization of federated learning present new challenges. Communication between the clients and the server is considered a main bottleneck in the convergence time of federated learning. In this paper, we propose and study Adaptive Federated Dropout (AFD), a novel technique to reduce the communication costs associated with federated learning. It optimizes both server-client communications and computation costs by allowing clients to train locally on a selected subset of the global model. We empirically show that this strategy, combined with existing compression methods, collectively provides up to 57x reduction in convergence time. It also outperforms the state-of-the-art solutions for communication efficiency. Furthermore, it improves model generalization by up to 1.7%.