Hierarchical Prototype-based Domain Priors for Multiple Instance Learning in Multimodal Histopathology Analysis

Digital pathology has fundamentally altered diagnostic workflows by enabling the computational analysis of gigapixel Whole Slide Images (WSIs), yet effectively deciphering their complex tumor microenvironments remains a formidable challenge. Existing Multiple Instance Learning (MIL) frameworks typically treat Whole Slide Images as unstructured bags of patches, discarding critical morphological semantics and spatial geometry. This lack of inductive bias often leads to overfitting on background noise and fails to align visual features with high-level diagnostic knowledge. To overcome these limitations, we propose the Hierarchical Prototype-based Domain Priors (HPDP) framework, a unified multimodal approach for joint histopathology diagnosis and prognosis. HPDP mitigates the data-driven "black box" issue by introducing a Morphologically Anchored Prototype System (MAPS), which anchors learning to interpretable morphological clusters, and a Sinusoidal Positional Encoder (SPE) to explicitly model tissue architecture. Furthermore, we bridge the semantic gap via a Hierarchical Cross-Modal Alignment (HCMA) module, using Large Language Model (LLM)-generated descriptions to contextually refine visual representations. Extensive experiments across seven cancer cohorts demonstrate that HPDP consistently achieves state-of-the-art performance with superior robustness and interpretability.

NTIRE 2025 Challenge on Event-Based Image Deblurring: Methods and Results

This paper presents an overview of NTIRE 2025 the First Challenge on Event-Based Image Deblurring, detailing the proposed methodologies and corresponding results. The primary goal of the challenge is to design an event-based method that achieves high-quality image deblurring, with performance quantitatively assessed using Peak Signal-to-Noise Ratio (PSNR). Notably, there are no restrictions on computational complexity or model size. The task focuses on leveraging both events and images as inputs for single-image deblurring. A total of 199 participants registered, among whom 15 teams successfully submitted valid results, offering valuable insights into the current state of event-based image deblurring. We anticipate that this challenge will drive further advancements in event-based vision research.

CausalCellSegmenter: Causal Inference inspired Diversified Aggregation Convolution for Pathology Image Segmentation

Deep learning models have shown promising performance for cell nucleus segmentation in the field of pathology image analysis. However, training a robust model from multiple domains remains a great challenge for cell nucleus segmentation. Additionally, the shortcomings of background noise, highly overlapping between cell nucleus, and blurred edges often lead to poor performance. To address these challenges, we propose a novel framework termed CausalCellSegmenter, which combines Causal Inference Module (CIM) with Diversified Aggregation Convolution (DAC) techniques. The DAC module is designed which incorporates diverse downsampling features through a simple, parameter-free attention module (SimAM), aiming to overcome the problems of false-positive identification and edge blurring. Furthermore, we introduce CIM to leverage sample weighting by directly removing the spurious correlations between features for every input sample and concentrating more on the correlation between features and labels. Extensive experiments on the MoNuSeg-2018 dataset achieves promising results, outperforming other state-of-the-art methods, where the mIoU and DSC scores growing by 3.6% and 2.65%.