A Client-server Deep Federated Learning for Cross-domain Surgical Image Segmentation

This paper presents a solution to the cross-domain adaptation problem for 2D surgical image segmentation, explicitly considering the privacy protection of distributed datasets belonging to different centers. Deep learning architectures in medical image analysis necessitate extensive training data for better generalization. However, obtaining sufficient diagnostic and surgical data is still challenging, mainly due to the inherent cost of data curation and the need of experts for data annotation. Moreover, increased privacy and legal compliance concerns can make data sharing across clinical sites or regions difficult. Another ubiquitous challenge the medical datasets face is inevitable domain shifts among the collected data at the different centers. To this end, we propose a Client-server deep federated architecture for cross-domain adaptation. A server hosts a set of immutable parameters common to both the source and target domains. The clients consist of the respective domain-specific parameters and make requests to the server while learning their parameters and inferencing. We evaluate our framework in two benchmark datasets, demonstrating applicability in computer-assisted interventions for endoscopic polyp segmentation and diagnostic skin lesion detection and analysis. Our extensive quantitative and qualitative experiments demonstrate the superiority of the proposed method compared to competitive baseline and state-of-the-art methods. Codes are available at: https://github.com/thetna/distributed-da

T2FNorm: Extremely Simple Scaled Train-time Feature Normalization for OOD Detection

Neural networks are notorious for being overconfident predictors, posing a significant challenge to their safe deployment in real-world applications. While feature normalization has garnered considerable attention within the deep learning literature, current train-time regularization methods for Out-of-Distribution(OOD) detection are yet to fully exploit this potential. Indeed, the naive incorporation of feature normalization within neural networks does not guarantee substantial improvement in OOD detection performance. In this work, we introduce T2FNorm, a novel approach to transforming features to hyperspherical space during training, while employing non-transformed space for OOD-scoring purposes. This method yields a surprising enhancement in OOD detection capabilities without compromising model accuracy in in-distribution(ID). Our investigation demonstrates that the proposed technique substantially diminishes the norm of the features of all samples, more so in the case of out-of-distribution samples, thereby addressing the prevalent concern of overconfidence in neural networks. The proposed method also significantly improves various post-hoc OOD detection methods.

Online estimation of the hand-eye transformation from surgical scenes

Hand-eye calibration algorithms are mature and provide accurate transformation estimations for an effective camera-robot link but rely on a sufficiently wide range of calibration data to avoid errors and degenerate configurations. To solve the hand-eye problem in robotic-assisted minimally invasive surgery and also simplify the calibration procedure by using neural network method cooporating with the new objective function. We present a neural network-based solution that estimates the transformation from a sequence of images and kinematic data which significantly simplifies the calibration procedure. The network utilises the long short-term memory architecture to extract temporal information from the data and solve the hand-eye problem. The objective function is derived from the linear combination of remote centre of motion constraint, the re-projection error and its derivative to induce a small change in the hand-eye transformation. The method is validated with the data from da Vinci Si and the result shows that the estimated hand-eye matrix is able to re-project the end-effector from the robot coordinate to the camera coordinate within 10 to 20 pixels of accuracy in both testing dataset. The calibration performance is also superior to the previous neural network-based hand-eye method. The proposed algorithm shows that the calibration procedure can be simplified by using deep learning techniques and the performance is improved by the assumption of non-static hand-eye transformations.

Surgical tool classification and localization: results and methods from the MICCAI 2022 SurgToolLoc challenge

The ability to automatically detect and track surgical instruments in endoscopic videos can enable transformational interventions. Assessing surgical performance and efficiency, identifying skilled tool use and choreography, and planning operational and logistical aspects of OR resources are just a few of the applications that could benefit. Unfortunately, obtaining the annotations needed to train machine learning models to identify and localize surgical tools is a difficult task. Annotating bounding boxes frame-by-frame is tedious and time-consuming, yet large amounts of data with a wide variety of surgical tools and surgeries must be captured for robust training. Moreover, ongoing annotator training is needed to stay up to date with surgical instrument innovation. In robotic-assisted surgery, however, potentially informative data like timestamps of instrument installation and removal can be programmatically harvested. The ability to rely on tool installation data alone would significantly reduce the workload to train robust tool-tracking models. With this motivation in mind we invited the surgical data science community to participate in the challenge, SurgToolLoc 2022. The goal was to leverage tool presence data as weak labels for machine learning models trained to detect tools and localize them in video frames with bounding boxes. We present the results of this challenge along with many of the team's efforts. We conclude by discussing these results in the broader context of machine learning and surgical data science. The training data used for this challenge consisting of 24,695 video clips with tool presence labels is also being released publicly and can be accessed at https://console.cloud.google.com/storage/browser/isi-surgtoolloc-2022.

Shifted-Windows Transformers for the Detection of Cerebral Aneurysms in Microsurgery

Purpose: Microsurgical Aneurysm Clipping Surgery (MACS) carries a high risk for intraoperative aneurysm rupture. Automated recognition of instances when the aneurysm is exposed in the surgical video would be a valuable reference point for neuronavigation, indicating phase transitioning and more importantly designating moments of high risk for rupture. This article introduces the MACS dataset containing 16 surgical videos with frame-level expert annotations and proposes a learning methodology for surgical scene understanding identifying video frames with the aneurysm present in the operating microscope's field-of-view. Methods: Despite the dataset imbalance (80% no presence, 20% presence) and developed without explicit annotations, we demonstrate the applicability of Transformer-based deep learning architectures (MACSSwin-T, vidMACSSwin-T) to detect the aneurysm and classify MACS frames accordingly. We evaluate the proposed models in multiple-fold cross-validation experiments with independent sets and in an unseen set of 15 images against 10 human experts (neurosurgeons). Results: Average (across folds) accuracy of 80.8% (range 78.5%-82.4%) and 87.1% (range 85.1%-91.3%) is obtained for the image- and video-level approach respectively, demonstrating that the models effectively learn the classification task. Qualitative evaluation of the models' class activation maps show these to be localized on the aneurysm's actual location. Depending on the decision threshold, MACSWin-T achieves 66.7% to 86.7% accuracy in the unseen images, compared to 82% of human raters, with moderate to strong correlation.

Local Navigation Among Movable Obstacles with Deep Reinforcement Learning

Autonomous robots would benefit a lot by gaining the ability to manipulate their environment to solve path planning tasks, known as the Navigation Among Movable Obstacle (NAMO) problem. In this paper, we present a deep reinforcement learning approach for solving NAMO locally, near narrow passages. We train parallel agents in physics simulation using an Advantage Actor-Critic based algorithm with a multi-modal neural network. We present an online policy that is able to push obstacles in a non-axial-aligned fashion, react to unexpected obstacle dynamics in real-time, and solve the local NAMO problem. Experimental validation in simulation shows that the presented approach generalises to unseen NAMO problems in unknown environments. We further demonstrate the implementation of the policy on a real quadrupedal robot, showing that the policy can deal with real-world sensor noises and uncertainties in unseen NAMO tasks.

3D Generative Model Latent Disentanglement via Local Eigenprojection

Designing realistic digital humans is extremely complex. Most data-driven generative models used to simplify the creation of their underlying geometric shape do not offer control over the generation of local shape attributes. In this paper, we overcome this limitation by introducing a novel loss function grounded in spectral geometry and applicable to different neural-network-based generative models of 3D head and body meshes. Encouraging the latent variables of mesh variational autoencoders (VAEs) or generative adversarial networks (GANs) to follow the local eigenprojections of identity attributes, we improve latent disentanglement and properly decouple the attribute creation. Experimental results show that our local eigenprojection disentangled (LED) models not only offer improved disentanglement with respect to the state-of-the-art, but also maintain good generation capabilities with training times comparable to the vanilla implementations of the models.

Deep Reinforcement Learning for Concentric Tube Robot Path Planning

As surgical interventions trend towards minimally invasive approaches, Concentric Tube Robots (CTRs) have been explored for various interventions such as brain, eye, fetoscopic, lung, cardiac and prostate surgeries. Arranged concentrically, each tube is rotated and translated independently to move the robot end-effector position, making kinematics and control challenging. Classical model-based approaches have been previously investigated with developments in deep learning based approaches outperforming more classical approaches in both forward kinematics and shape estimation. We propose a deep reinforcement learning approach to control where we generalise across two to four systems, an element not yet achieved in any other deep learning approach for CTRs. In this way we explore the likely robustness of the control approach. Also investigated is the impact of rotational constraints applied on tube actuation and the effects on error metrics. We evaluate inverse kinematics errors and tracking error for path following tasks and compare the results to those achieved using state of the art methods. Additionally, as current results are performed in simulation, we also investigate a domain transfer approach known as domain randomization and evaluate error metrics as an initial step towards hardware implementation. Finally, we compare our method to a Jacobian approach found in literature.

Learning ultrasound plane pose regression: assessing generalized pose coordinates in the fetal brain

In obstetric ultrasound (US) scanning, the learner's ability to mentally build a three-dimensional (3D) map of the fetus from a two-dimensional (2D) US image represents a significant challenge in skill acquisition. We aim to build a US plane localization system for 3D visualization, training, and guidance without integrating additional sensors. This work builds on top of our previous work, which predicts the six-dimensional (6D) pose of arbitrarily-oriented US planes slicing the fetal brain with respect to a normalized reference frame using a convolutional neural network (CNN) regression network. Here, we analyze in detail the assumptions of the normalized fetal brain reference frame and quantify its accuracy with respect to the acquisition of transventricular (TV) standard plane (SP) for fetal biometry. We investigate the impact of registration quality in the training and testing data and its subsequent effect on trained models. Finally, we introduce data augmentations and larger training sets that improve the results of our previous work, achieving median errors of 3.53 mm and 6.42 degrees for translation and rotation, respectively.

MoBYv2AL: Self-supervised Active Learning for Image Classification

Active learning(AL) has recently gained popularity for deep learning(DL) models. This is due to efficient and informative sampling, especially when the learner requires large-scale labelled datasets. Commonly, the sampling and training happen in stages while more batches are added. One main bottleneck in this strategy is the narrow representation learned by the model that affects the overall AL selection. We present MoBYv2AL, a novel self-supervised active learning framework for image classification. Our contribution lies in lifting MoBY, one of the most successful self-supervised learning algorithms, to the AL pipeline. Thus, we add the downstream task-aware objective function and optimize it jointly with contrastive loss. Further, we derive a data-distribution selection function from labelling the new examples. Finally, we test and study our pipeline robustness and performance for image classification tasks. We successfully achieved state-of-the-art results when compared to recent AL methods. Code available: https://github.com/razvancaramalau/MoBYv2AL