Modular Memory is the Key to Continual Learning Agents

Foundation models have transformed machine learning through large-scale pretraining and increased test-time compute. Despite surpassing human performance in several domains, these models remain fundamentally limited in continuous operation, experience accumulation, and personalization, capabilities that are central to adaptive intelligence. While continual learning research has long targeted these goals, its historical focus on in-weight learning (IWL), i.e., updating a single model's parameters to absorb new knowledge, has rendered catastrophic forgetting a persistent challenge. Our position is that combining the strengths of In-Weight Learning (IWL) and the newly emerged capabilities of In-Context Learning (ICL) through the design of modular memory is the missing piece for continual adaptation at scale. We outline a conceptual framework for modular memory-centric architectures that leverage ICL for rapid adaptation and knowledge accumulation, and IWL for stable updates to model capabilities, charting a practical roadmap toward continually learning agents.

Benchmarking Video Foundation Models for Remote Parkinson's Disease Screening

Remote, video-based assessments offer a scalable pathway for Parkinson's disease (PD) screening. While traditional approaches rely on handcrafted features mimicking clinical scales, recent advances in video foundation models (VFMs) enable representation learning without task-specific customization. However, the comparative effectiveness of different VFM architectures across diverse clinical tasks remains poorly understood. We present a large-scale systematic study using a novel video dataset from 1,888 participants (727 with PD), comprising 32,847 videos across 16 standardized clinical tasks. We evaluate seven state-of-the-art VFMs -- including VideoPrism, V-JEPA, ViViT, and VideoMAE -- to determine their robustness in clinical screening. By evaluating frozen embeddings with a linear classification head, we demonstrate that task saliency is highly model-dependent: VideoPrism excels in capturing visual speech kinematics (no audio) and facial expressivity, while V-JEPA proves superior for upper-limb motor tasks. Notably, TimeSformer remains highly competitive for rhythmic tasks like finger tapping. Our experiments yield AUCs of 76.4-85.3% and accuracies of 71.5-80.6%. While high specificity (up to 90.3%) suggests strong potential for ruling out healthy individuals, the lower sensitivity (43.2-57.3%) highlights the need for task-aware calibration and integration of multiple tasks and modalities. Overall, this work establishes a rigorous baseline for VFM-based PD screening and provides a roadmap for selecting suitable tasks and architectures in remote neurological monitoring. Code and anonymized structured data are publicly available: https://anonymous.4open.science/r/parkinson\_video\_benchmarking-A2C5

Dynamic Sparse Training of Diagonally Sparse Networks

Recent advances in Dynamic Sparse Training (DST) have pushed the frontier of sparse neural network training in structured and unstructured contexts, matching dense-model performance while drastically reducing parameter counts to facilitate model scaling. However, unstructured sparsity often fails to translate into practical speedups on modern hardware. To address this shortcoming, we propose DynaDiag, a novel structured sparse-to-sparse DST method that performs at par with unstructured sparsity. DynaDiag enforces a diagonal sparsity pattern throughout training and preserves sparse computation in forward and backward passes. We further leverage the diagonal structure to accelerate computation via a custom CUDA kernel, rendering the method hardware-friendly. Empirical evaluations on diverse neural architectures demonstrate that our method maintains accuracy on par with unstructured counterparts while benefiting from tangible computational gains. Notably, with 90% sparse linear layers in ViTs, we observe up to a 3.13x speedup in online inference without sacrificing model performance and a 1.59x speedup in training on a GPU compared to equivalent unstructured layers. Our source code is available at https://github.com/horizon-research/DynaDiag/.

A Good Start Matters: Enhancing Continual Learning with Data-Driven Weight Initialization

To adapt to real-world data streams, continual learning (CL) systems must rapidly learn new concepts while preserving and utilizing prior knowledge. When it comes to adding new information to continually-trained deep neural networks (DNNs), classifier weights for newly encountered categories are typically initialized randomly, leading to high initial training loss (spikes) and instability. Consequently, achieving optimal convergence and accuracy requires prolonged training, increasing computational costs. Inspired by Neural Collapse (NC), we propose a weight initialization strategy to improve learning efficiency in CL. In DNNs trained with mean-squared-error, NC gives rise to a Least-Square (LS) classifier in the last layer, whose weights can be analytically derived from learned features. We leverage this LS formulation to initialize classifier weights in a data-driven manner, aligning them with the feature distribution rather than using random initialization. Our method mitigates initial loss spikes and accelerates adaptation to new tasks. We evaluate our approach in large-scale CL settings, demonstrating faster adaptation and improved CL performance.

INSIGHT: Explainable Weakly-Supervised Medical Image Analysis

Due to their large sizes, volumetric scans and whole-slide pathology images (WSIs) are often processed by extracting embeddings from local regions and then an aggregator makes predictions from this set. However, current methods require post-hoc visualization techniques (e.g., Grad-CAM) and often fail to localize small yet clinically crucial details. To address these limitations, we introduce INSIGHT, a novel weakly-supervised aggregator that integrates heatmap generation as an inductive bias. Starting from pre-trained feature maps, INSIGHT employs a detection module with small convolutional kernels to capture fine details and a context module with a broader receptive field to suppress local false positives. The resulting internal heatmap highlights diagnostically relevant regions. On CT and WSI benchmarks, INSIGHT achieves state-of-the-art classification results and high weakly-labeled semantic segmentation performance. Project website and code are available at: https://zhangdylan83.github.io/ewsmia/

Improving Multimodal Large Language Models Using Continual Learning

Generative large language models (LLMs) exhibit impressive capabilities, which can be further augmented by integrating a pre-trained vision model into the original LLM to create a multimodal LLM (MLLM). However, this integration often significantly decreases performance on natural language understanding and generation tasks, compared to the original LLM. This study investigates this issue using the LLaVA MLLM, treating the integration as a continual learning problem. We evaluate five continual learning methods to mitigate forgetting and identify a technique that enhances visual understanding while minimizing linguistic performance loss. Our approach reduces linguistic performance degradation by up to 15\% over the LLaVA recipe, while maintaining high multimodal accuracy. We also demonstrate the robustness of our method through continual learning on a sequence of vision-language tasks, effectively preserving linguistic skills while acquiring new multimodal capabilities.

Can Kans (re)discover predictive models for Direct-Drive Laser Fusion?

The domain of laser fusion presents a unique and challenging predictive modeling application landscape for machine learning methods due to high problem complexity and limited training data. Data-driven approaches utilizing prescribed functional forms, inductive biases and physics-informed learning (PIL) schemes have been successful in the past for achieving desired generalization ability and model interpretation that aligns with physics expectations. In complex multi-physics application domains, however, it is not always obvious how architectural biases or discriminative penalties can be formulated. In this work, focusing on nuclear fusion energy using high powered lasers, we present the use of Kolmogorov-Arnold Networks (KANs) as an alternative to PIL for developing a new type of data-driven predictive model which is able to achieve high prediction accuracy and physics interpretability. A KAN based model, a MLP with PIL, and a baseline MLP model are compared in generalization ability and interpretation with a domain expert-derived symbolic regression model. Through empirical studies in this high physics complexity domain, we show that KANs can potentially provide benefits when developing predictive models for data-starved physics applications.

Revisiting Multi-Modal LLM Evaluation

With the advent of multi-modal large language models (MLLMs), datasets used for visual question answering (VQA) and referring expression comprehension have seen a resurgence. However, the most popular datasets used to evaluate MLLMs are some of the earliest ones created, and they have many known problems, including extreme bias, spurious correlations, and an inability to permit fine-grained analysis. In this paper, we pioneer evaluating recent MLLMs (LLaVA 1.5, LLaVA-NeXT, BLIP2, InstructBLIP, GPT-4V, and GPT-4o) on datasets designed to address weaknesses in earlier ones. We assess three VQA datasets: 1) TDIUC, which permits fine-grained analysis on 12 question types; 2) TallyQA, which has simple and complex counting questions; and 3) DVQA, which requires optical character recognition for chart understanding. We also study VQDv1, a dataset that requires identifying all image regions that satisfy a given query. Our experiments reveal the weaknesses of many MLLMs that have not previously been reported. Our code is integrated into the widely used LAVIS framework for MLLM evaluation, enabling the rapid assessment of future MLLMs. Project webpage: https://kevinlujian.github.io/MLLM_Evaluations/

What Variables Affect Out-Of-Distribution Generalization in Pretrained Models?

Embeddings produced by pre-trained deep neural networks (DNNs) are widely used; however, their efficacy for downstream tasks can vary widely. We study the factors influencing out-of-distribution (OOD) generalization of pre-trained DNN embeddings through the lens of the tunnel effect hypothesis, which suggests deeper DNN layers compress representations and hinder OOD performance. Contrary to earlier work, we find the tunnel effect is not universal. Based on 10,584 linear probes, we study the conditions that mitigate the tunnel effect by varying DNN architecture, training dataset, image resolution, and augmentations. We quantify each variable's impact using a novel SHAP analysis. Our results emphasize the danger of generalizing findings from toy datasets to broader contexts.

PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology

Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a mismatch between most clinical analysis, which is defined at the level of one or more whole slide images, and foundation models to date, which process the thousands of image tiles contained in a whole slide image separately. The requirement to train a network to aggregate information across a large number of tiles in multiple whole slide images limits these models' impact. In this work, we present a slide-level foundation model for H&E-stained histopathology, PRISM, that builds on Virchow tile embeddings and leverages clinical report text for pre-training. Using the tile embeddings, PRISM produces slide-level embeddings with the ability to generate clinical reports, resulting in several modes of use. Using text prompts, PRISM achieves zero-shot cancer detection and sub-typing performance approaching and surpassing that of a supervised aggregator model. Using the slide embeddings with linear classifiers, PRISM surpasses supervised aggregator models. Furthermore, we demonstrate that fine-tuning of the PRISM slide encoder yields label-efficient training for biomarker prediction, a task that typically suffers from low availability of training data; an aggregator initialized with PRISM and trained on as little as 10% of the training data can outperform a supervised baseline that uses all of the data.