THUNDER: Tile-level Histopathology image UNDERstanding benchmark

Progress in a research field can be hard to assess, in particular when many concurrent methods are proposed in a short period of time. This is the case in digital pathology, where many foundation models have been released recently to serve as feature extractors for tile-level images, being used in a variety of downstream tasks, both for tile- and slide-level problems. Benchmarking available methods then becomes paramount to get a clearer view of the research landscape. In particular, in critical domains such as healthcare, a benchmark should not only focus on evaluating downstream performance, but also provide insights about the main differences between methods, and importantly, further consider uncertainty and robustness to ensure a reliable usage of proposed models. For these reasons, we introduce THUNDER, a tile-level benchmark for digital pathology foundation models, allowing for efficient comparison of many models on diverse datasets with a series of downstream tasks, studying their feature spaces and assessing the robustness and uncertainty of predictions informed by their embeddings. THUNDER is a fast, easy-to-use, dynamic benchmark that can already support a large variety of state-of-the-art foundation, as well as local user-defined models for direct tile-based comparison. In this paper, we provide a comprehensive comparison of 23 foundation models on 16 different datasets covering diverse tasks, feature analysis, and robustness. The code for THUNDER is publicly available at https://github.com/MICS-Lab/thunder.

Prompt learning with bounding box constraints for medical image segmentation

Pixel-wise annotations are notoriously labourious and costly to obtain in the medical domain. To mitigate this burden, weakly supervised approaches based on bounding box annotations-much easier to acquire-offer a practical alternative. Vision foundation models have recently shown noteworthy segmentation performance when provided with prompts such as points or bounding boxes. Prompt learning exploits these models by adapting them to downstream tasks and automating segmentation, thereby reducing user intervention. However, existing prompt learning approaches depend on fully annotated segmentation masks. This paper proposes a novel framework that combines the representational power of foundation models with the annotation efficiency of weakly supervised segmentation. More specifically, our approach automates prompt generation for foundation models using only bounding box annotations. Our proposed optimization scheme integrates multiple constraints derived from box annotations with pseudo-labels generated by the prompted foundation model. Extensive experiments across multimodal datasets reveal that our weakly supervised method achieves an average Dice score of 84.90% in a limited data setting, outperforming existing fully-supervised and weakly-supervised approaches. The code is available at https://github.com/Minimel/box-prompt-learning-VFM.git

Test-Time Adaptation of Vision-Language Models for Open-Vocabulary Semantic Segmentation

Recently, test-time adaptation has attracted wide interest in the context of vision-language models for image classification. However, to the best of our knowledge, the problem is completely overlooked in dense prediction tasks such as Open-Vocabulary Semantic Segmentation (OVSS). In response, we propose a novel TTA method tailored to adapting VLMs for segmentation during test time. Unlike TTA methods for image classification, our Multi-Level and Multi-Prompt (MLMP) entropy minimization integrates features from intermediate vision-encoder layers and is performed with different text-prompt templates at both the global CLS token and local pixel-wise levels. Our approach could be used as plug-and-play for any segmentation network, does not require additional training data or labels, and remains effective even with a single test sample. Furthermore, we introduce a comprehensive OVSS TTA benchmark suite, which integrates a rigorous evaluation protocol, seven segmentation datasets, and 15 common corruptions, with a total of 82 distinct test scenarios, establishing a standardized and comprehensive testbed for future TTA research in open-vocabulary segmentation. Our experiments on this suite demonstrate that our segmentation-tailored method consistently delivers significant gains over direct adoption of TTA classification baselines.

SMART-PC: Skeletal Model Adaptation for Robust Test-Time Training in Point Clouds

Test-Time Training (TTT) has emerged as a promising solution to address distribution shifts in 3D point cloud classification. However, existing methods often rely on computationally expensive backpropagation during adaptation, limiting their applicability in real-world, time-sensitive scenarios. In this paper, we introduce SMART-PC, a skeleton-based framework that enhances resilience to corruptions by leveraging the geometric structure of 3D point clouds. During pre-training, our method predicts skeletal representations, enabling the model to extract robust and meaningful geometric features that are less sensitive to corruptions, thereby improving adaptability to test-time distribution shifts. Unlike prior approaches, SMART-PC achieves real-time adaptation by eliminating backpropagation and updating only BatchNorm statistics, resulting in a lightweight and efficient framework capable of achieving high frame-per-second rates while maintaining superior classification performance. Extensive experiments on benchmark datasets, including ModelNet40-C, ShapeNet-C, and ScanObjectNN-C, demonstrate that SMART-PC achieves state-of-the-art results, outperforming existing methods such as MATE in terms of both accuracy and computational efficiency. The implementation is available at: https://github.com/AliBahri94/SMART-PC.

DART$^3$: Leveraging Distance for Test Time Adaptation in Person Re-Identification

Person re-identification (ReID) models are known to suffer from camera bias, where learned representations cluster according to camera viewpoints rather than identity, leading to significant performance degradation under (inter-camera) domain shifts in real-world surveillance systems when new cameras are added to camera networks. State-of-the-art test-time adaptation (TTA) methods, largely designed for classification tasks, rely on classification entropy-based objectives that fail to generalize well to ReID, thus making them unsuitable for tackling camera bias. In this paper, we introduce DART$^3$, a TTA framework specifically designed to mitigate camera-induced domain shifts in person ReID. DART$^3$ (Distance-Aware Retrieval Tuning at Test Time) leverages a distance-based objective that aligns better with image retrieval tasks like ReID by exploiting the correlation between nearest-neighbor distance and prediction error. Unlike prior ReID-specific domain adaptation methods, DART$^3$ requires no source data, architectural modifications, or retraining, and can be deployed in both fully black-box and hybrid settings. Empirical evaluations on multiple ReID benchmarks indicate that DART$^3$ and DART$^3$ LITE, a lightweight alternative to the approach, consistently outperforms state-of-the-art TTA baselines, making for a viable option to online learning to mitigate the adverse effects of camera bias.

Correcting Deviations from Normality: A Reformulated Diffusion Model for Multi-Class Unsupervised Anomaly Detection

Recent advances in diffusion models have spurred research into their application for Reconstruction-based unsupervised anomaly detection. However, these methods may struggle with maintaining structural integrity and recovering the anomaly-free content of abnormal regions, especially in multi-class scenarios. Furthermore, diffusion models are inherently designed to generate images from pure noise and struggle to selectively alter anomalous regions of an image while preserving normal ones. This leads to potential degradation of normal regions during reconstruction, hampering the effectiveness of anomaly detection. This paper introduces a reformulation of the standard diffusion model geared toward selective region alteration, allowing the accurate identification of anomalies. By modeling anomalies as noise in the latent space, our proposed Deviation correction diffusion (DeCo-Diff) model preserves the normal regions and encourages transformations exclusively on anomalous areas. This selective approach enhances the reconstruction quality, facilitating effective unsupervised detection and localization of anomaly regions. Comprehensive evaluations demonstrate the superiority of our method in accurately identifying and localizing anomalies in complex images, with pixel-level AUPRC improvements of 11-14% over state-of-the-art models on well known anomaly detection datasets. The code is available at https://github.com/farzad-bz/DeCo-Diff

Spectral State Space Model for Rotation-Invariant~Visual~Representation~Learning

State Space Models (SSMs) have recently emerged as an alternative to Vision Transformers (ViTs) due to their unique ability of modeling global relationships with linear complexity. SSMs are specifically designed to capture spatially proximate relationships of image patches. However, they fail to identify relationships between conceptually related yet not adjacent patches. This limitation arises from the non-causal nature of image data, which lacks inherent directional relationships. Additionally, current vision-based SSMs are highly sensitive to transformations such as rotation. Their predefined scanning directions depend on the original image orientation, which can cause the model to produce inconsistent patch-processing sequences after rotation. To address these limitations, we introduce Spectral VMamba, a novel approach that effectively captures the global structure within an image by leveraging spectral information derived from the graph Laplacian of image patches. Through spectral decomposition, our approach encodes patch relationships independently of image orientation, achieving rotation invariance with the aid of our Rotational Feature Normalizer (RFN) module. Our experiments on classification tasks show that Spectral VMamba outperforms the leading SSM models in vision, such as VMamba, while maintaining invariance to rotations and a providing a similar runtime efficiency.

Spectral Informed Mamba for Robust Point Cloud Processing

State space models have shown significant promise in Natural Language Processing (NLP) and, more recently, computer vision. This paper introduces a new methodology leveraging Mamba and Masked Autoencoder networks for point cloud data in both supervised and self-supervised learning. We propose three key contributions to enhance Mamba's capability in processing complex point cloud structures. First, we exploit the spectrum of a graph Laplacian to capture patch connectivity, defining an isometry-invariant traversal order that is robust to viewpoints and better captures shape manifolds than traditional 3D grid-based traversals. Second, we adapt segmentation via a recursive patch partitioning strategy informed by Laplacian spectral components, allowing finer integration and segment analysis. Third, we address token placement in Masked Autoencoder for Mamba by restoring tokens to their original positions, which preserves essential order and improves learning. Extensive experiments demonstrate the improvements of our approach in classification, segmentation, and few-shot tasks over state-of-the-art baselines.

MAD-AD: Masked Diffusion for Unsupervised Brain Anomaly Detection

Unsupervised anomaly detection in brain images is crucial for identifying injuries and pathologies without access to labels. However, the accurate localization of anomalies in medical images remains challenging due to the inherent complexity and variability of brain structures and the scarcity of annotated abnormal data. To address this challenge, we propose a novel approach that incorporates masking within diffusion models, leveraging their generative capabilities to learn robust representations of normal brain anatomy. During training, our model processes only normal brain MRI scans and performs a forward diffusion process in the latent space that adds noise to the features of randomly-selected patches. Following a dual objective, the model learns to identify which patches are noisy and recover their original features. This strategy ensures that the model captures intricate patterns of normal brain structures while isolating potential anomalies as noise in the latent space. At inference, the model identifies noisy patches corresponding to anomalies and generates a normal counterpart for these patches by applying a reverse diffusion process. Our method surpasses existing unsupervised anomaly detection techniques, demonstrating superior performance in generating accurate normal counterparts and localizing anomalies. The code is available at hhttps://github.com/farzad-bz/MAD-AD.

ReC-TTT: Contrastive Feature Reconstruction for Test-Time Training

The remarkable progress in deep learning (DL) showcases outstanding results in various computer vision tasks. However, adaptation to real-time variations in data distributions remains an important challenge. Test-Time Training (TTT) was proposed as an effective solution to this issue, which increases the generalization ability of trained models by adding an auxiliary task at train time and then using its loss at test time to adapt the model. Inspired by the recent achievements of contrastive representation learning in unsupervised tasks, we propose ReC-TTT, a test-time training technique that can adapt a DL model to new unseen domains by generating discriminative views of the input data. ReC-TTT uses cross-reconstruction as an auxiliary task between a frozen encoder and two trainable encoders, taking advantage of a single shared decoder. This enables, at test time, to adapt the encoders to extract features that will be correctly reconstructed by the decoder that, in this phase, is frozen on the source domain. Experimental results show that ReC-TTT achieves better results than other state-of-the-art techniques in most domain shift classification challenges.