A Comprehensive Review of Artificial Intelligence Applications in Major Retinal Conditions

This paper provides a systematic survey of retinal diseases that cause visual impairments or blindness, emphasizing the importance of early detection for effective treatment. It covers both clinical and automated approaches for detecting retinal disease, focusing on studies from the past decade. The survey evaluates various algorithms for identifying structural abnormalities and diagnosing retinal diseases, and it identifies future research directions based on a critical analysis of existing literature. This comprehensive study, which reviews both clinical and automated detection methods using different modalities, appears to be unique in its scope. Additionally, the survey serves as a helpful guide for researchers interested in digital retinopathy.

Incremental Cross-Domain Adaptation for Robust Retinopathy Screening via Bayesian Deep Learning

Retinopathy represents a group of retinal diseases that, if not treated timely, can cause severe visual impairments or even blindness. Many researchers have developed autonomous systems to recognize retinopathy via fundus and optical coherence tomography (OCT) imagery. However, most of these frameworks employ conventional transfer learning and fine-tuning approaches, requiring a decent amount of well-annotated training data to produce accurate diagnostic performance. This paper presents a novel incremental cross-domain adaptation instrument that allows any deep classification model to progressively learn abnormal retinal pathologies in OCT and fundus imagery via few-shot training. Furthermore, unlike its competitors, the proposed instrument is driven via a Bayesian multi-objective function that not only enforces the candidate classification network to retain its prior learned knowledge during incremental training but also ensures that the network understands the structural and semantic relationships between previously learned pathologies and newly added disease categories to effectively recognize them at the inference stage. The proposed framework, evaluated on six public datasets acquired with three different scanners to screen thirteen retinal pathologies, outperforms the state-of-the-art competitors by achieving an overall accuracy and F1 score of 0.9826 and 0.9846, respectively.

Automated segmentation and extraction of posterior eye segment using OCT scans

This paper proposes an automated method for the segmentation and extraction of the posterior segment of the human eye, including the vitreous, retina, choroid, and sclera compartments, using multi-vendor optical coherence tomography (OCT) scans. The proposed method works in two phases. First extracts the retinal pigment epithelium (RPE) layer by applying the adaptive thresholding technique to identify the retina-choroid junction. Then, it exploits the structure tensor guided approach to extract the inner limiting membrane (ILM) and the choroidal stroma (CS) layers, locating the vitreous-retina and choroid-sclera junctions in the candidate OCT scan. Furthermore, these three junction boundaries are utilized to conduct posterior eye compartmentalization effectively for both healthy and disease eye OCT scans. The proposed framework is evaluated over 1000 OCT scans, where it obtained the mean intersection over union (IoU) and mean Dice similarity coefficient (DSC) scores of 0.874 and 0.930, respectively.

SIP-SegNet: A Deep Convolutional Encoder-Decoder Network for Joint Semantic Segmentation and Extraction of Sclera, Iris and Pupil based on Periocular Region Suppression

The current developments in the field of machine vision have opened new vistas towards deploying multimodal biometric recognition systems in various real-world applications. These systems have the ability to deal with the limitations of unimodal biometric systems which are vulnerable to spoofing, noise, non-universality and intra-class variations. In addition, the ocular traits among various biometric traits are preferably used in these recognition systems. Such systems possess high distinctiveness, permanence, and performance while, technologies based on other biometric traits (fingerprints, voice etc.) can be easily compromised. This work presents a novel deep learning framework called SIP-SegNet, which performs the joint semantic segmentation of ocular traits (sclera, iris and pupil) in unconstrained scenarios with greater accuracy. The acquired images under these scenarios exhibit purkinje reflexes, specular reflections, eye gaze, off-angle shots, low resolution, and various occlusions particularly by eyelids and eyelashes. To address these issues, SIP-SegNet begins with denoising the pristine image using denoising convolutional neural network (DnCNN), followed by reflection removal and image enhancement based on contrast limited adaptive histogram equalization (CLAHE). Our proposed framework then extracts the periocular information using adaptive thresholding and employs the fuzzy filtering technique to suppress this information. Finally, the semantic segmentation of sclera, iris and pupil is achieved using the densely connected fully convolutional encoder-decoder network. We used five CASIA datasets to evaluate the performance of SIP-SegNet based on various evaluation metrics. The simulation results validate the optimal segmentation of the proposed SIP-SegNet, with the mean f1 scores of 93.35, 95.11 and 96.69 for the sclera, iris and pupil classes respectively.