Randomized Confidence Bounds for Stochastic Partial Monitoring

The partial monitoring (PM) framework provides a theoretical formulation of sequential learning problems with incomplete feedback. On each round, a learning agent plays an action while the environment simultaneously chooses an outcome. The agent then observes a feedback signal that is only partially informative about the (unobserved) outcome. The agent leverages the received feedback signals to select actions that minimize the (unobserved) cumulative loss. In contextual PM, the outcomes depend on some side information that is observable by the agent before selecting the action on each round. In this paper, we consider the contextual and non-contextual PM settings with stochastic outcomes. We introduce a new class of strategies based on the randomization of deterministic confidence bounds, that extend regret guarantees to settings where existing stochastic strategies are not applicable. Our experiments show that the proposed RandCBP and RandCBPside* strategies improve state-of-the-art baselines in PM games. To encourage the adoption of the PM framework, we design a use case on the real-world problem of monitoring the error rate of any deployed classification system.

Association Rules Mining with Auto-Encoders

Association rule mining is one of the most studied research fields of data mining, with applications ranging from grocery basket problems to explainable classification systems. Classical association rule mining algorithms have several limitations, especially with regards to their high execution times and number of rules produced. Over the past decade, neural network solutions have been used to solve various optimization problems, such as classification, regression or clustering. However there are still no efficient way association rules using neural networks. In this paper, we present an auto-encoder solution to mine association rule called ARM-AE. We compare our algorithm to FP-Growth and NSGAII on three categorical datasets, and show that our algorithm discovers high support and confidence rule set and has a better execution time than classical methods while preserving the quality of the rule set produced.

Interpret Your Care: Predicting the Evolution of Symptoms for Cancer Patients

Cancer treatment is an arduous process for patients and causes many side-effects during and post-treatment. The treatment can affect almost all body systems and result in pain, fatigue, sleep disturbances, cognitive impairments, etc. These conditions are often under-diagnosed or under-treated. In this paper, we use patient data to predict the evolution of their symptoms such that treatment-related impairments can be prevented or effects meaningfully ameliorated. The focus of this study is on predicting the pain and tiredness level of a patient post their diagnosis. We implement an interpretable decision tree based model called LightGBM on real-world patient data consisting of 20163 patients. There exists a class imbalance problem in the dataset which we resolve using the oversampling technique of SMOTE. Our empirical results show that the value of the previous level of a symptom is a key indicator for prediction and the weighted average deviation in prediction of pain level is 3.52 and of tiredness level is 2.27.

Neural Bandits for Data Mining: Searching for Dangerous Polypharmacy

Polypharmacy, most often defined as the simultaneous consumption of five or more drugs at once, is a prevalent phenomenon in the older population. Some of these polypharmacies, deemed inappropriate, may be associated with adverse health outcomes such as death or hospitalization. Considering the combinatorial nature of the problem as well as the size of claims database and the cost to compute an exact association measure for a given drug combination, it is impossible to investigate every possible combination of drugs. Therefore, we propose to optimize the search for potentially inappropriate polypharmacies (PIPs). To this end, we propose the OptimNeuralTS strategy, based on Neural Thompson Sampling and differential evolution, to efficiently mine claims datasets and build a predictive model of the association between drug combinations and health outcomes. We benchmark our method using two datasets generated by an internally developed simulator of polypharmacy data containing 500 drugs and 100 000 distinct combinations. Empirically, our method can detect up to 33\% of PIPs while maintaining an average precision score of 99\% using 10 000 time steps.

Cambrian Explosion Algorithm for Multi-Objective Association Rules Mining

Association rule mining is one of the most studied research fields of data mining, with applications ranging from grocery basket problems to highly explainable classification systems. Classical association rule mining algorithms have several flaws especially with regards to their execution times, memory usage and number of rules produced. An alternative is the use of meta-heuristics, which have been used on several optimisation problems. This paper has two objectives. First, we provide a comparison of the performances of state-of-the-art meta-heuristics on the association rule mining problem. We use the multi-objective versions of those algorithms using support, confidence and cosine. Second, we propose a new algorithm designed to mine rules efficiently from massive datasets by exploring a large variety of solutions, akin to the explosion of species diversity of the Cambrian Explosion. We compare our algorithm to 20 benchmark algorithms on 22 real-world data-sets, and show that our algorithm present good results and outperform several state-of-the-art algorithms.

GrowSpace: Learning How to Shape Plants

Plants are dynamic systems that are integral to our existence and survival. Plants face environment changes and adapt over time to their surrounding conditions. We argue that plant responses to an environmental stimulus are a good example of a real-world problem that can be approached within a reinforcement learning (RL)framework. With the objective of controlling a plant by moving the light source, we propose GrowSpace, as a new RL benchmark. The back-end of the simulator is implemented using the Space Colonisation Algorithm, a plant growing model based on competition for space. Compared to video game RL environments, this simulator addresses a real-world problem and serves as a test bed to visualize plant growth and movement in a faster way than physical experiments. GrowSpace is composed of a suite of challenges that tackle several problems such as control, multi-stage learning,fairness and multi-objective learning. We provide agent baselines alongside case studies to demonstrate the difficulty of the proposed benchmark.

Challenges in Statistical Analysis of Data Collected by a Bandit Algorithm: An Empirical Exploration in Applications to Adaptively Randomized Experiments

Multi-armed bandit algorithms have been argued for decades as useful for adaptively randomized experiments. In such experiments, an algorithm varies which arms (e.g. alternative interventions to help students learn) are assigned to participants, with the goal of assigning higher-reward arms to as many participants as possible. We applied the bandit algorithm Thompson Sampling (TS) to run adaptive experiments in three university classes. Instructors saw great value in trying to rapidly use data to give their students in the experiments better arms (e.g. better explanations of a concept). Our deployment, however, illustrated a major barrier for scientists and practitioners to use such adaptive experiments: a lack of quantifiable insight into how much statistical analysis of specific real-world experiments is impacted (Pallmann et al, 2018; FDA, 2019), compared to traditional uniform random assignment. We therefore use our case study of the ubiquitous two-arm binary reward setting to empirically investigate the impact of using Thompson Sampling instead of uniform random assignment. In this setting, using common statistical hypothesis tests, we show that collecting data with TS can as much as double the False Positive Rate (FPR; incorrectly reporting differences when none exist) and the False Negative Rate (FNR; failing to report differences when they exist)...

Comparison of pharmacist evaluation of medication orders with predictions of a machine learning model

The objective of this work was to assess the clinical performance of an unsupervised machine learning model aimed at identifying unusual medication orders and pharmacological profiles. We conducted a prospective study between April 2020 and August 2020 where 25 clinical pharmacists dichotomously (typical or atypical) rated 12,471 medication orders and 1,356 pharmacological profiles. Based on AUPR, performance was poor for orders, but satisfactory for profiles. Pharmacists considered the model a useful screening tool.

Deep interpretability for GWAS

Genome-Wide Association Studies are typically conducted using linear models to find genetic variants associated with common diseases. In these studies, association testing is done on a variant-by-variant basis, possibly missing out on non-linear interaction effects between variants. Deep networks can be used to model these interactions, but they are difficult to train and interpret on large genetic datasets. We propose a method that uses the gradient based deep interpretability technique named DeepLIFT to show that known diabetes genetic risk factors can be identified using deep models along with possibly novel associations.

A Robust Self-Learning Method for Fully Unsupervised Cross-Lingual Mappings of Word Embeddings: Making the Method Robustly Reproducible as Well

In this paper, we reproduce the experiments of Artetxe et al. (2018b) regarding the robust self-learning method for fully unsupervised cross-lingual mappings of word embeddings. We show that the reproduction of their method is indeed feasible with some minor assumptions. We further investigate the robustness of their model by introducing four new languages that are less similar to English than the ones proposed by the original paper. In order to assess the stability of their model, we also conduct a grid search over sensible hyperparameters. We then propose key recommendations applicable to any research project in order to deliver fully reproducible research.