The Next Layer: Augmenting Foundation Models with Structure-Preserving and Attention-Guided Learning for Local Patches to Global Context Awareness in Computational Pathology

Foundation models have recently emerged as powerful feature extractors in computational pathology, yet they typically omit mechanisms for leveraging the global spatial structure of tissues and the local contextual relationships among diagnostically relevant regions - key elements for understanding the tumor microenvironment. Multiple instance learning (MIL) remains an essential next step following foundation model, designing a framework to aggregate patch-level features into slide-level predictions. We present EAGLE-Net, a structure-preserving, attention-guided MIL architecture designed to augment prediction and interpretability. EAGLE-Net integrates multi-scale absolute spatial encoding to capture global tissue architecture, a top-K neighborhood-aware loss to focus attention on local microenvironments, and background suppression loss to minimize false positives. We benchmarked EAGLE-Net on large pan-cancer datasets, including three cancer types for classification (10,260 slides) and seven cancer types for survival prediction (4,172 slides), using three distinct histology foundation backbones (REMEDIES, Uni-V1, Uni2-h). Across tasks, EAGLE-Net achieved up to 3% higher classification accuracy and the top concordance indices in 6 of 7 cancer types, producing smooth, biologically coherent attention maps that aligned with expert annotations and highlighted invasive fronts, necrosis, and immune infiltration. These results position EAGLE-Net as a generalizable, interpretable framework that complements foundation models, enabling improved biomarker discovery, prognostic modeling, and clinical decision support

Thinking Beyond Tokens: From Brain-Inspired Intelligence to Cognitive Foundations for Artificial General Intelligence and its Societal Impact

Can machines truly think, reason and act in domains like humans? This enduring question continues to shape the pursuit of Artificial General Intelligence (AGI). Despite the growing capabilities of models such as GPT-4.5, DeepSeek, Claude 3.5 Sonnet, Phi-4, and Grok 3, which exhibit multimodal fluency and partial reasoning, these systems remain fundamentally limited by their reliance on token-level prediction and lack of grounded agency. This paper offers a cross-disciplinary synthesis of AGI development, spanning artificial intelligence, cognitive neuroscience, psychology, generative models, and agent-based systems. We analyze the architectural and cognitive foundations of general intelligence, highlighting the role of modular reasoning, persistent memory, and multi-agent coordination. In particular, we emphasize the rise of Agentic RAG frameworks that combine retrieval, planning, and dynamic tool use to enable more adaptive behavior. We discuss generalization strategies, including information compression, test-time adaptation, and training-free methods, as critical pathways toward flexible, domain-agnostic intelligence. Vision-Language Models (VLMs) are reexamined not just as perception modules but as evolving interfaces for embodied understanding and collaborative task completion. We also argue that true intelligence arises not from scale alone but from the integration of memory and reasoning: an orchestration of modular, interactive, and self-improving components where compression enables adaptive behavior. Drawing on advances in neurosymbolic systems, reinforcement learning, and cognitive scaffolding, we explore how recent architectures begin to bridge the gap between statistical learning and goal-directed cognition. Finally, we identify key scientific, technical, and ethical challenges on the path to AGI.

Action Segmentation Using 2D Skeleton Heatmaps

This paper presents a 2D skeleton-based action segmentation method with applications in fine-grained human activity recognition. In contrast with state-of-the-art methods which directly take sequences of 3D skeleton coordinates as inputs and apply Graph Convolutional Networks (GCNs) for spatiotemporal feature learning, our main idea is to use sequences of 2D skeleton heatmaps as inputs and employ Temporal Convolutional Networks (TCNs) to extract spatiotemporal features. Despite lacking 3D information, our approach yields comparable/superior performances and better robustness against missing keypoints than previous methods on action segmentation datasets. Moreover, we improve the performances further by using both 2D skeleton heatmaps and RGB videos as inputs. To our best knowledge, this is the first work to utilize 2D skeleton heatmap inputs and the first work to explore 2D skeleton+RGB fusion for action segmentation.

Permutation-Aware Action Segmentation via Unsupervised Frame-to-Segment Alignment

This paper presents a novel transformer-based framework for unsupervised activity segmentation which leverages not only frame-level cues but also segment-level cues. This is in contrast with previous methods which often rely on frame-level information only. Our approach begins with a frame-level prediction module which estimates framewise action classes via a transformer encoder. The frame-level prediction module is trained in an unsupervised manner via temporal optimal transport. To exploit segment-level information, we introduce a segment-level prediction module and a frame-to-segment alignment module. The former includes a transformer decoder for estimating video transcripts, while the latter matches frame-level features with segment-level features, yielding permutation-aware segmentation results. Moreover, inspired by temporal optimal transport, we develop simple-yet-effective pseudo labels for unsupervised training of the above modules. Our experiments on four public datasets, i.e., 50 Salads, YouTube Instructions, Breakfast, and Desktop Assembly show that our approach achieves comparable or better performance than previous methods in unsupervised activity segmentation.

Brain Tumor Synthetic Data Generation with Adaptive StyleGANs

Generative models have been very successful over the years and have received significant attention for synthetic data generation. As deep learning models are getting more and more complex, they require large amounts of data to perform accurately. In medical image analysis, such generative models play a crucial role as the available data is limited due to challenges related to data privacy, lack of data diversity, or uneven data distributions. In this paper, we present a method to generate brain tumor MRI images using generative adversarial networks. We have utilized StyleGAN2 with ADA methodology to generate high-quality brain MRI with tumors while using a significantly smaller amount of training data when compared to the existing approaches. We use three pre-trained models for transfer learning. Results demonstrate that the proposed method can learn the distributions of brain tumors. Furthermore, the model can generate high-quality synthetic brain MRI with a tumor that can limit the small sample size issues. The approach can addresses the limited data availability by generating realistic-looking brain MRI with tumors. The code is available at: ~\url{https://github.com/rizwanqureshi123/Brain-Tumor-Synthetic-Data}.