Systemic Biases in Sign Language AI Research: A Deaf-Led Call to Reevaluate Research Agendas

Growing research in sign language recognition, generation, and translation AI has been accompanied by calls for ethical development of such technologies. While these works are crucial to helping individual researchers do better, there is a notable lack of discussion of systemic biases or analysis of rhetoric that shape the research questions and methods in the field, especially as it remains dominated by hearing non-signing researchers. Therefore, we conduct a systematic review of 101 recent papers in sign language AI. Our analysis identifies significant biases in the current state of sign language AI research, including an overfocus on addressing perceived communication barriers, a lack of use of representative datasets, use of annotations lacking linguistic foundations, and development of methods that build on flawed models. We take the position that the field lacks meaningful input from Deaf stakeholders, and is instead driven by what decisions are the most convenient or perceived as important to hearing researchers. We end with a call to action: the field must make space for Deaf researchers to lead the conversation in sign language AI.

ASL Citizen: A Community-Sourced Dataset for Advancing Isolated Sign Language Recognition

Sign languages are used as a primary language by approximately 70 million D/deaf people world-wide. However, most communication technologies operate in spoken and written languages, creating inequities in access. To help tackle this problem, we release ASL Citizen, the largest Isolated Sign Language Recognition (ISLR) dataset to date, collected with consent and containing 83,912 videos for 2,731 distinct signs filmed by 52 signers in a variety of environments. We propose that this dataset be used for sign language dictionary retrieval for American Sign Language (ASL), where a user demonstrates a sign to their own webcam with the aim of retrieving matching signs from a dictionary. We show that training supervised machine learning classifiers with our dataset greatly advances the state-of-the-art on metrics relevant for dictionary retrieval, achieving, for instance, 62% accuracy and a recall-at-10 of 90%, evaluated entirely on videos of users who are not present in the training or validation sets. An accessible PDF of this article is available at https://aashakadesai.github.io/research/ASL_Dataset__arxiv_.pdf

Protein structure generation via folding diffusion

The ability to computationally generate novel yet physically foldable protein structures could lead to new biological discoveries and new treatments targeting yet incurable diseases. Despite recent advances in protein structure prediction, directly generating diverse, novel protein structures from neural networks remains difficult. In this work, we present a new diffusion-based generative model that designs protein backbone structures via a procedure that mirrors the native folding process. We describe protein backbone structure as a series of consecutive angles capturing the relative orientation of the constituent amino acid residues, and generate new structures by denoising from a random, unfolded state towards a stable folded structure. Not only does this mirror how proteins biologically twist into energetically favorable conformations, the inherent shift and rotational invariance of this representation crucially alleviates the need for complex equivariant networks. We train a denoising diffusion probabilistic model with a simple transformer backbone and demonstrate that our resulting model unconditionally generates highly realistic protein structures with complexity and structural patterns akin to those of naturally-occurring proteins. As a useful resource, we release the first open-source codebase and trained models for protein structure diffusion.

CytoImageNet: A large-scale pretraining dataset for bioimage transfer learning

Motivation: In recent years, image-based biological assays have steadily become high-throughput, sparking a need for fast automated methods to extract biologically-meaningful information from hundreds of thousands of images. Taking inspiration from the success of ImageNet, we curate CytoImageNet, a large-scale dataset of openly-sourced and weakly-labeled microscopy images (890K images, 894 classes). Pretraining on CytoImageNet yields features that are competitive to ImageNet features on downstream microscopy classification tasks. We show evidence that CytoImageNet features capture information not available in ImageNet-trained features. The dataset is made available at https://www.kaggle.com/stanleyhua/cytoimagenet.

Random Embeddings and Linear Regression can Predict Protein Function

Large self-supervised models pretrained on millions of protein sequences have recently gained popularity in generating embeddings of protein sequences for protein function prediction. However, the absence of random baselines makes it difficult to conclude whether pretraining has learned useful information for protein function prediction. Here we show that one-hot encoding and random embeddings, both of which do not require any pretraining, are strong baselines for protein function prediction across 14 diverse sequence-to-function tasks.

Evolution Is All You Need: Phylogenetic Augmentation for Contrastive Learning

Self-supervised representation learning of biological sequence embeddings alleviates computational resource constraints on downstream tasks while circumventing expensive experimental label acquisition. However, existing methods mostly borrow directly from large language models designed for NLP, rather than with bioinformatics philosophies in mind. Recently, contrastive mutual information maximization methods have achieved state-of-the-art representations for ImageNet. In this perspective piece, we discuss how viewing evolution as natural sequence augmentation and maximizing information across phylogenetic "noisy channels" is a biologically and theoretically desirable objective for pretraining encoders. We first provide a review of current contrastive learning literature, then provide an illustrative example where we show that contrastive learning using evolutionary augmentation can be used as a representation learning objective which maximizes the mutual information between biological sequences and their conserved function, and finally outline rationale for this approach.

The Cells Out of Sample dataset and benchmarks for measuring out-of-sample generalization of image classifiers

Understanding if classifiers generalize to out-of-sample datasets is a central problem in machine learning. Microscopy images provide a standardized way to measure the generalization capacity of image classifiers, as we can image the same classes of objects under increasingly divergent, but controlled factors of variation. We created a public dataset of 132,209 images of mouse cells, COOS-7 (Cells Out Of Sample 7-Class). COOS-7 provides a classification setting where four test datasets have increasing degrees of covariate shift: some images are random subsets of the training data, while others are from experiments reproduced months later and imaged by different instruments. We benchmarked a range of classification models using different representations, including transferred neural network features, end-to-end classification with a supervised deep CNN, and features from a self-supervised CNN. While most classifiers perform well on test datasets similar to the training dataset, all classifiers failed to generalize their performance to datasets with greater covariate shifts. These baselines highlight the challenges of covariate shifts in image data, and establish metrics for improving the generalization capacity of image classifiers.