CreoPep: A Universal Deep Learning Framework for Target-Specific Peptide Design and Optimization

Target-specific peptides, such as conotoxins, exhibit exceptional binding affinity and selectivity toward ion channels and receptors. However, their therapeutic potential remains underutilized due to the limited diversity of natural variants and the labor-intensive nature of traditional optimization strategies. Here, we present CreoPep, a deep learning-based conditional generative framework that integrates masked language modeling with a progressive masking scheme to design high-affinity peptide mutants while uncovering novel structural motifs. CreoPep employs an integrative augmentation pipeline, combining FoldX-based energy screening with temperature-controlled multinomial sampling, to generate structurally and functionally diverse peptides that retain key pharmacological properties. We validate this approach by designing conotoxin inhibitors targeting the $\alpha$7 nicotinic acetylcholine receptor, achieving submicromolar potency in electrophysiological assays. Structural analysis reveals that CreoPep-generated variants engage in both conserved and novel binding modes, including disulfide-deficient forms, thus expanding beyond conventional design paradigms. Overall, CreoPep offers a robust and generalizable platform that bridges computational peptide design with experimental validation, accelerating the discovery of next-generation peptide therapeutics.

CMEdataset Advancing China Map Detection and Standardization with Digital Image Resources

Digital images of Chinas maps play a crucial role in map detection, particularly in ensuring national sovereignty, territorial integrity, and map compliance. However, there is currently no publicly available dataset specifically dedicated to problematic maps the CME dataset. Existing datasets primarily focus on general map data and are insufficient for effectively identifying complex issues such as national boundary misrepresentations, missing elements, and blurred boundaries. Therefore, this study creates a Problematic Map dataset that covers five key problem areas, aiming to provide diverse samples for problematic map detection technologies, support high-precision map compliance detection, and enhance map data quality and timeliness. This dataset not only provides essential resources for map compliance, national security monitoring, and map updates, but also fosters innovation and application of related technologies.