Exploring Protein Language Model Architecture-Induced Biases for Antibody Comprehension

Recent advances in protein language models (PLMs) have demonstrated remarkable capabilities in understanding protein sequences. However, the extent to which different model architectures capture antibody-specific biological properties remains unexplored. In this work, we systematically investigate how architectural choices in PLMs influence their ability to comprehend antibody sequence characteristics and functions. We evaluate three state-of-the-art PLMs-AntiBERTa, BioBERT, and ESM2--against a general-purpose language model (GPT-2) baseline on antibody target specificity prediction tasks. Our results demonstrate that while all PLMs achieve high classification accuracy, they exhibit distinct biases in capturing biological features such as V gene usage, somatic hypermutation patterns, and isotype information. Through attention attribution analysis, we show that antibody-specific models like AntiBERTa naturally learn to focus on complementarity-determining regions (CDRs), while general protein models benefit significantly from explicit CDR-focused training strategies. These findings provide insights into the relationship between model architecture and biological feature extraction, offering valuable guidance for future PLM development in computational antibody design.

Beyond a Single Perspective: Towards a Realistic Evaluation of Website Fingerprinting Attacks

Website Fingerprinting (WF) attacks exploit patterns in encrypted traffic to infer the websites visited by users, posing a serious threat to anonymous communication systems. Although recent WF techniques achieve over 90% accuracy in controlled experimental settings, most studies remain confined to single scenarios, overlooking the complexity of real-world environments. This paper presents the first systematic and comprehensive evaluation of existing WF attacks under diverse realistic conditions, including defense mechanisms, traffic drift, multi-tab browsing, early-stage detection, open-world settings, and few-shot scenarios. Experimental results show that many WF techniques with strong performance in isolated settings degrade significantly when facing other conditions. Since real-world environments often combine multiple challenges, current WF attacks are difficult to apply directly in practice. This study highlights the limitations of WF attacks and introduces a multidimensional evaluation framework, offering critical insights for developing more robust and practical WF attacks.

Spatial-ORMLLM: Improve Spatial Relation Understanding in the Operating Room with Multimodal Large Language Model

Precise spatial modeling in the operating room (OR) is foundational to many clinical tasks, supporting intraoperative awareness, hazard avoidance, and surgical decision-making. While existing approaches leverage large-scale multimodal datasets for latent-space alignment to implicitly learn spatial relationships, they overlook the 3D capabilities of MLLMs. However, this approach raises two issues: (1) Operating rooms typically lack multiple video and audio sensors, making multimodal 3D data difficult to obtain; (2) Training solely on readily available 2D data fails to capture fine-grained details in complex scenes. To address this gap, we introduce Spatial-ORMLLM, the first large vision-language model for 3D spatial reasoning in operating rooms using only RGB modality to infer volumetric and semantic cues, enabling downstream medical tasks with detailed and holistic spatial context. Spatial-ORMLLM incorporates a Spatial-Enhanced Feature Fusion Block, which integrates 2D modality inputs with rich 3D spatial knowledge extracted by the estimation algorithm and then feeds the combined features into the visual tower. By employing a unified end-to-end MLLM framework, it combines powerful spatial features with textual features to deliver robust 3D scene reasoning without any additional expert annotations or sensor inputs. Experiments on multiple benchmark clinical datasets demonstrate that Spatial-ORMLLM achieves state-of-the-art performance and generalizes robustly to previously unseen surgical scenarios and downstream tasks.

AsyncFlow: An Asynchronous Streaming RL Framework for Efficient LLM Post-Training

Reinforcement learning (RL) has become a pivotal technology in the post-training phase of large language models (LLMs). Traditional task-colocated RL frameworks suffer from significant scalability bottlenecks, while task-separated RL frameworks face challenges in complex dataflows and the corresponding resource idling and workload imbalance. Moreover, most existing frameworks are tightly coupled with LLM training or inference engines, making it difficult to support custom-designed engines. To address these challenges, we propose AsyncFlow, an asynchronous streaming RL framework for efficient post-training. Specifically, we introduce a distributed data storage and transfer module that provides a unified data management and fine-grained scheduling capability in a fully streamed manner. This architecture inherently facilitates automated pipeline overlapping among RL tasks and dynamic load balancing. Moreover, we propose a producer-consumer-based asynchronous workflow engineered to minimize computational idleness by strategically deferring parameter update process within staleness thresholds. Finally, the core capability of AsynFlow is architecturally decoupled from underlying training and inference engines and encapsulated by service-oriented user interfaces, offering a modular and customizable user experience. Extensive experiments demonstrate an average of 1.59 throughput improvement compared with state-of-the-art baseline. The presented architecture in this work provides actionable insights for next-generation RL training system designs.

CLTP: Contrastive Language-Tactile Pre-training for 3D Contact Geometry Understanding

Recent advancements in integrating tactile sensing with vision-language models (VLMs) have demonstrated remarkable potential for robotic multimodal perception. However, existing tactile descriptions remain limited to superficial attributes like texture, neglecting critical contact states essential for robotic manipulation. To bridge this gap, we propose CLTP, an intuitive and effective language tactile pretraining framework that aligns tactile 3D point clouds with natural language in various contact scenarios, thus enabling contact-state-aware tactile language understanding for contact-rich manipulation tasks. We first collect a novel dataset of 50k+ tactile 3D point cloud-language pairs, where descriptions explicitly capture multidimensional contact states (e.g., contact location, shape, and force) from the tactile sensor's perspective. CLTP leverages a pre-aligned and frozen vision-language feature space to bridge holistic textual and tactile modalities. Experiments validate its superiority in three downstream tasks: zero-shot 3D classification, contact state classification, and tactile 3D large language model (LLM) interaction. To the best of our knowledge, this is the first study to align tactile and language representations from the contact state perspective for manipulation tasks, providing great potential for tactile-language-action model learning. Code and datasets are open-sourced at https://sites.google.com/view/cltp/.