A dataset of primary nasopharyngeal carcinoma MRI with multi-modalities segmentation

Multi-modality magnetic resonance imaging data with various sequences facilitate the early diagnosis, tumor segmentation, and disease staging in the management of nasopharyngeal carcinoma (NPC). The lack of publicly available, comprehensive datasets limits advancements in diagnosis, treatment planning, and the development of machine learning algorithms for NPC. Addressing this critical need, we introduce the first comprehensive NPC MRI dataset, encompassing MR axial imaging of 277 primary NPC patients. This dataset includes T1-weighted, T2-weighted, and contrast-enhanced T1-weighted sequences, totaling 831 scans. In addition to the corresponding clinical data, manually annotated and labeled segmentations by experienced radiologists offer high-quality data resources from untreated primary NPC.

Quantitative perfusion maps using a novelty spatiotemporal convolutional neural network

Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is widely used to evaluate acute ischemic stroke to distinguish salvageable tissue and infarct core. For this purpose, traditional methods employ deconvolution techniques, like singular value decomposition, which are known to be vulnerable to noise, potentially distorting the derived perfusion parameters. However, deep learning technology could leverage it, which can accurately estimate clinical perfusion parameters compared to traditional clinical approaches. Therefore, this study presents a perfusion parameters estimation network that considers spatial and temporal information, the Spatiotemporal Network (ST-Net), for the first time. The proposed network comprises a designed physical loss function to enhance model performance further. The results indicate that the network can accurately estimate perfusion parameters, including cerebral blood volume (CBV), cerebral blood flow (CBF), and time to maximum of the residual function (Tmax). The structural similarity index (SSIM) mean values for CBV, CBF, and Tmax parameters were 0.952, 0.943, and 0.863, respectively. The DICE score for the hypo-perfused region reached 0.859, demonstrating high consistency. The proposed model also maintains time efficiency, closely approaching the performance of commercial gold-standard software.