SzCORE: A Seizure Community Open-source Research Evaluation framework for the validation of EEG-based automated seizure detection algorithms

The need for high-quality automated seizure detection algorithms based on electroencephalography (EEG) becomes ever more pressing with the increasing use of ambulatory and long-term EEG monitoring. Heterogeneity in validation methods of these algorithms influences the reported results and makes comprehensive evaluation and comparison challenging. This heterogeneity concerns in particular the choice of datasets, evaluation methodologies, and performance metrics. In this paper, we propose a unified framework designed to establish standardization in the validation of EEG-based seizure detection algorithms. Based on existing guidelines and recommendations, the framework introduces a set of recommendations and standards related to datasets, file formats, EEG data input content, seizure annotation input and output, cross-validation strategies, and performance metrics. We also propose the 10-20 seizure detection benchmark, a machine-learning benchmark based on public datasets converted to a standardized format. This benchmark defines the machine-learning task as well as reporting metrics. We illustrate the use of the benchmark by evaluating a set of existing seizure detection algorithms. The SzCORE (Seizure Community Open-source Research Evaluation) framework and benchmark are made publicly available along with an open-source software library to facilitate research use, while enabling rigorous evaluation of the clinical significance of the algorithms, fostering a collective effort to more optimally detect seizures to improve the lives of people with epilepsy.

Enhancing Performance, Calibration Time and Efficiency in Brain-Machine Interfaces through Transfer Learning and Wearable EEG Technology

Brain-machine interfaces (BMIs) have emerged as a transformative force in assistive technologies, empowering individuals with motor impairments by enabling device control and facilitating functional recovery. However, the persistent challenge of inter-session variability poses a significant hurdle, requiring time-consuming calibration at every new use. Compounding this issue, the low comfort level of current devices further restricts their usage. To address these challenges, we propose a comprehensive solution that combines a tiny CNN-based Transfer Learning (TL) approach with a comfortable, wearable EEG headband. The novel wearable EEG device features soft dry electrodes placed on the headband and is capable of on-board processing. We acquire multiple sessions of motor-movement EEG data and achieve up to 96% inter-session accuracy using TL, greatly reducing the calibration time and improving usability. By executing the inference on the edge every 100ms, the system is estimated to achieve 30h of battery life. The comfortable BMI setup with tiny CNN and TL paves the way to future on-device continual learning, essential for tackling inter-session variability and improving usability.

EpiDeNet: An Energy-Efficient Approach to Seizure Detection for Embedded Systems

Epilepsy is a prevalent neurological disorder that affects millions of individuals globally, and continuous monitoring coupled with automated seizure detection appears as a necessity for effective patient treatment. To enable long-term care in daily-life conditions, comfortable and smart wearable devices with long battery life are required, which in turn set the demand for resource-constrained and energy-efficient computing solutions. In this context, the development of machine learning algorithms for seizure detection faces the challenge of heavily imbalanced datasets. This paper introduces EpiDeNet, a new lightweight seizure detection network, and Sensitivity-Specificity Weighted Cross-Entropy (SSWCE), a new loss function that incorporates sensitivity and specificity, to address the challenge of heavily unbalanced datasets. The proposed EpiDeNet-SSWCE approach demonstrates the successful detection of 91.16% and 92.00% seizure events on two different datasets (CHB-MIT and PEDESITE, respectively), with only four EEG channels. A three-window majority voting-based smoothing scheme combined with the SSWCE loss achieves 3x reduction of false positives to 1.18 FP/h. EpiDeNet is well suited for implementation on low-power embedded platforms, and we evaluate its performance on two ARM Cortex-based platforms (M4F/M7) and two parallel ultra-low power (PULP) systems (GAP8, GAP9). The most efficient implementation (GAP9) achieves an energy efficiency of 40 GMAC/s/W, with an energy consumption per inference of only 0.051 mJ at high performance (726.46 MMAC/s), outperforming the best ARM Cortex-based solutions by approximately 160x in energy efficiency. The EpiDeNet-SSWCE method demonstrates effective and accurate seizure detection performance on heavily imbalanced datasets, while being suited for implementation on energy-constrained platforms.

Exploring Automatic Gym Workouts Recognition Locally On Wearable Resource-Constrained Devices

Automatic gym activity recognition on energy- and resource-constrained wearable devices removes the human-interaction requirement during intense gym sessions - like soft-touch tapping and swiping. This work presents a tiny and highly accurate residual convolutional neural network that runs in milliwatt microcontrollers for automatic workouts classification. We evaluated the inference performance of the deep model with quantization on three resource-constrained devices: two microcontrollers with ARM-Cortex M4 and M7 core from ST Microelectronics, and a GAP8 system on chip, which is an open-sourced, multi-core RISC-V computing platform from GreenWaves Technologies. Experimental results show an accuracy of up to 90.4% for eleven workouts recognition with full precision inference. The paper also presents the trade-off performance of the resource-constrained system. While keeping the recognition accuracy (88.1%) with minimal loss, each inference takes only 3.2 ms on GAP8, benefiting from the 8 RISC-V cluster cores. We measured that it features an execution time that is 18.9x and 6.5x faster than the Cortex-M4 and Cortex-M7 cores, showing the feasibility of real-time on-board workouts recognition based on the described data set with 20 Hz sampling rate. The energy consumed for each inference on GAP8 is 0.41 mJ compared to 5.17 mJ on Cortex-M4 and 8.07 mJ on Cortex-M7 with the maximum clock. It can lead to longer battery life when the system is battery-operated. We also introduced an open data set composed of fifty sessions of eleven gym workouts collected from ten subjects that is publicly available.

Nonlinear and Machine Learning Analyses on High-Density EEG data of Math Experts and Novices

Current trend in neurosciences is to use naturalistic stimuli, such as cinema, class-room biology or video gaming, aiming to understand the brain functions during ecologically valid conditions. Naturalistic stimuli recruit complex and overlapping cognitive, emotional and sensory brain processes. Brain oscillations form underlying mechanisms for such processes, and further, these processes can be modified by expertise. Human cortical oscillations are often analyzed with linear methods despite brain as a biological system is highly nonlinear. This study applies a relatively robust nonlinear method, Higuchi fractal dimension (HFD), to classify cortical oscillations of math experts and novices when they solve long and complex math demonstrations in an EEG laboratory. Brain imaging data, which is collected over a long time span during naturalistic stimuli, enables the application of data-driven analyses. Therefore, we also explore the neural signature of math expertise with machine learning algorithms. There is a need for novel methodologies in analyzing naturalistic data because formulation of theories of the brain functions in the real world based on reductionist and simplified study designs is both challenging and questionable. Data-driven intelligent approaches may be helpful in developing and testing new theories on complex brain functions. Our results clarify the different neural signature, analyzed by HFD, of math experts and novices during complex math and suggest machine learning as a promising data-driven approach to understand the brain processes in expertise and mathematical cognition.

An Energy-Efficient Spiking Neural Network for Finger Velocity Decoding for Implantable Brain-Machine Interface

Brain-machine interfaces (BMIs) are promising for motor rehabilitation and mobility augmentation. High-accuracy and low-power algorithms are required to achieve implantable BMI systems. In this paper, we propose a novel spiking neural network (SNN) decoder for implantable BMI regression tasks. The SNN is trained with enhanced spatio-temporal backpropagation to fully leverage its ability in handling temporal problems. The proposed SNN decoder achieves the same level of correlation coefficient as the state-of-the-art ANN decoder in offline finger velocity decoding tasks, while it requires only 6.8% of the computation operations and 9.4% of the memory access.

Reducing Neural Architecture Search Spaces with Training-Free Statistics and Computational Graph Clustering

The computational demands of neural architecture search (NAS) algorithms are usually directly proportional to the size of their target search spaces. Thus, limiting the search to high-quality subsets can greatly reduce the computational load of NAS algorithms. In this paper, we present Clustering-Based REDuction (C-BRED), a new technique to reduce the size of NAS search spaces. C-BRED reduces a NAS space by clustering the computational graphs associated with its architectures and selecting the most promising cluster using proxy statistics correlated with network accuracy. When considering the NAS-Bench-201 (NB201) data set and the CIFAR-100 task, C-BRED selects a subset with 70% average accuracy instead of the whole space's 64% average accuracy.

MI-BMInet: An Efficient Convolutional Neural Network for Motor Imagery Brain--Machine Interfaces with EEG Channel Selection

A brain--machine interface (BMI) based on motor imagery (MI) enables the control of devices using brain signals while the subject imagines performing a movement. It plays an important role in prosthesis control and motor rehabilitation and is a crucial element towards the future Internet of Minds (IoM). To improve user comfort, preserve data privacy, and reduce the system's latency, a new trend in wearable BMIs is to embed algorithms on low-power microcontroller units (MCUs) to process the electroencephalographic (EEG) data in real-time close to the sensors into the wearable device. However, most of the classification models present in the literature are too resource-demanding, making them unfit for low-power MCUs. This paper proposes an efficient convolutional neural network (CNN) for EEG-based MI classification that achieves comparable accuracy while being orders of magnitude less resource-demanding and significantly more energy-efficient than state-of-the-art (SoA) models for a long-lifetime battery operation. We propose an automatic channel selection method based on spatial filters and quantize both weights and activations to 8-bit precision to further reduce the model complexity with negligible accuracy loss. Finally, we efficiently implement and evaluate the proposed models on a parallel ultra-low power (PULP) MCU. The most energy-efficient solution consumes only 50.10 uJ with an inference runtime of 5.53 ms and an accuracy of 82.51% while using 6.4x fewer EEG channels, becoming the new SoA for embedded MI-BMI and defining a new Pareto frontier in the three-way trade-off among accuracy, resource cost, and power usage.

Leveraging Tactile Sensors for Low Latency Embedded Smart Hands for Prosthetic and Robotic Applications

Tactile sensing is a crucial perception mode for robots and human amputees in need of controlling a prosthetic device. Today robotic and prosthetic systems are still missing the important feature of accurate tactile sensing. This lack is mainly due to the fact that the existing tactile technologies have limited spatial and temporal resolution and are either expensive or not scalable. In this paper, we present the design and the implementation of a hardware-software embedded system called SmartHand. It is specifically designed to enable the acquisition and the real-time processing of high-resolution tactile information from a hand-shaped multi-sensor array for prosthetic and robotic applications. During data collection, our system can deliver a high throughput of 100 frames per second, which is 13.7x higher than previous related work. We collected a new tactile dataset while interacting with daily-life objects during five different sessions. We propose a compact yet accurate convolutional neural network that requires one order of magnitude less memory and 15.6x fewer computations compared to related work without degrading classification accuracy. The top-1 and top-3 cross-validation accuracies are respectively 98.86% and 99.83%. We further analyze the inter-session variability and obtain the best top-3 leave-one-out-validation accuracy of 77.84%. We deploy the trained model on a high-performance ARM Cortex-M7 microcontroller achieving an inference time of only 100 ms minimizing the response latency. The overall measured power consumption is 505 mW. Finally, we fabricate a new control sensor and perform additional experiments to provide analyses on sensor degradation and slip detection. This work is a step forward in giving robotic and prosthetic devices a sense of touch and demonstrates the practicality of a smart embedded system empowered by tiny machine learning.

Sub-100uW Multispectral Riemannian Classification for EEG-based Brain--Machine Interfaces

Motor imagery brain--machine interfaces enable us to control machines by merely thinking of performing a motor action. Practical use cases require a wearable solution where the classification of the brain signals is done locally near the sensor using machine learning models embedded on energy-efficient microcontroller units, for assured privacy, user comfort, and long-term usage. In this work, we provide practical insights on the accuracy-cost trade-off for embedded BMI solutions. Our multispectral Riemannian classifier reaches 75.1% accuracy on a 4-class MI task. The accuracy is further improved by tuning different types of classifiers to each subject, achieving 76.4%. We further scale down the model by quantizing it to mixed-precision representations with a minimal accuracy loss of 1% and 1.4%, respectively, which is still up to 4.1% more accurate than the state-of-the-art embedded convolutional neural network. We implement the model on a low-power MCU within an energy budget of merely 198uJ and taking only 16.9ms per classification. Classifying samples continuously, overlapping the 3.5s samples by 50% to avoid missing user inputs allows for operation at just 85uW. Compared to related works in embedded MI-BMIs, our solution sets the new state-of-the-art in terms of accuracy-energy trade-off for near-sensor classification.