A Geometric Flow Approach for Segmentation of Images with Inhomongeneous Intensity and Missing Boundaries

Image segmentation is a complex mathematical problem, especially for images that contain intensity inhomogeneity and tightly packed objects with missing boundaries in between. For instance, Magnetic Resonance (MR) muscle images often contain both of these issues, making muscle segmentation especially difficult. In this paper we propose a novel intensity correction and a semi-automatic active contour based segmentation approach. The approach uses a geometric flow that incorporates a reproducing kernel Hilbert space (RKHS) edge detector and a geodesic distance penalty term from a set of markers and anti-markers. We test the proposed scheme on MR muscle segmentation and compare with some state of the art methods. To help deal with the intensity inhomogeneity in this particular kind of image, a new approach to estimate the bias field using a fat fraction image, called Prior Bias-Corrected Fuzzy C-means (PBCFCM), is introduced. Numerical experiments show that the proposed scheme leads to significantly better results than compared ones. The average dice values of the proposed method are 92.5%, 85.3%, 85.3% for quadriceps, hamstrings and other muscle groups while other approaches are at least 10% worse.

Unsupervised Deep Unrolled Reconstruction Using Regularization by Denoising

Deep learning methods have been successfully used in various computer vision tasks. Inspired by that success, deep learning has been explored in magnetic resonance imaging (MRI) reconstruction. In particular, integrating deep learning and model-based optimization methods has shown considerable advantages. However, a large amount of labeled training data is typically needed for high reconstruction quality, which is challenging for some MRI applications. In this paper, we propose a novel reconstruction method, named DURED-Net, that enables interpretable unsupervised learning for MR image reconstruction by combining an unsupervised denoising network and a plug-and-play method. We aim to boost the reconstruction performance of unsupervised learning by adding an explicit prior that utilizes imaging physics. Specifically, the leverage of a denoising network for MRI reconstruction is achieved using Regularization by Denoising (RED). Experiment results demonstrate that the proposed method requires a reduced amount of training data to achieve high reconstruction quality.

The International Workshop on Osteoarthritis Imaging Knee MRI Segmentation Challenge: A Multi-Institute Evaluation and Analysis Framework on a Standardized Dataset

Purpose: To organize a knee MRI segmentation challenge for characterizing the semantic and clinical efficacy of automatic segmentation methods relevant for monitoring osteoarthritis progression. Methods: A dataset partition consisting of 3D knee MRI from 88 subjects at two timepoints with ground-truth articular (femoral, tibial, patellar) cartilage and meniscus segmentations was standardized. Challenge submissions and a majority-vote ensemble were evaluated using Dice score, average symmetric surface distance, volumetric overlap error, and coefficient of variation on a hold-out test set. Similarities in network segmentations were evaluated using pairwise Dice correlations. Articular cartilage thickness was computed per-scan and longitudinally. Correlation between thickness error and segmentation metrics was measured using Pearson's coefficient. Two empirical upper bounds for ensemble performance were computed using combinations of model outputs that consolidated true positives and true negatives. Results: Six teams (T1-T6) submitted entries for the challenge. No significant differences were observed across all segmentation metrics for all tissues (p=1.0) among the four top-performing networks (T2, T3, T4, T6). Dice correlations between network pairs were high (>0.85). Per-scan thickness errors were negligible among T1-T4 (p=0.99) and longitudinal changes showed minimal bias (<0.03mm). Low correlations (<0.41) were observed between segmentation metrics and thickness error. The majority-vote ensemble was comparable to top performing networks (p=1.0). Empirical upper bound performances were similar for both combinations (p=1.0). Conclusion: Diverse networks learned to segment the knee similarly where high segmentation accuracy did not correlate to cartilage thickness accuracy. Voting ensembles did not outperform individual networks but may help regularize individual models.