MLC-GCN: Multi-Level Generated Connectome Based GCN for AD Analysis

Alzheimer's Disease (AD) is a currently incurable neurodegeneartive disease. Accurately detecting AD, especially in the early stage, represents a high research priority. AD is characterized by progressive cognitive impairments that are related to alterations in brain functional connectivity (FC). Based on this association, many studies have been published over the decades using FC and machine learning to differentiate AD from healthy aging. The most recent development in this detection method highlights the use of graph neural network (GNN) as the brain functionality analysis. In this paper, we proposed a stack of spatio-temporal feature extraction and graph generation based AD classification model using resting state fMRI. The proposed multi-level generated connectome (MLC) based graph convolutional network (GCN) (MLC-GCN) contains a multi-graph generation block and a GCN prediction block. The multi-graph generation block consists of a hierarchy of spatio-temporal feature extraction layers for extracting spatio-temporal rsfMRI features at different depths and building the corresponding connectomes. The GCN prediction block takes the learned multi-level connectomes to build and optimize GCNs at each level and concatenates the learned graphical features as the final predicting features for AD classification. Through independent cohort validations, MLC-GCN shows better performance for differentiating MCI, AD, and normal aging than state-of-art GCN and rsfMRI based AD classifiers. The proposed MLC-GCN also showed high explainability in terms of learning clinically reasonable connectome node and connectivity features from two independent datasets. While we only tested MLC-GCN on AD, the basic rsfMRI-based multi-level learned GCN based outcome prediction strategy is valid for other diseases or clinical outcomes.

CLIP-VIS: Adapting CLIP for Open-Vocabulary Video Instance Segmentation

Open-vocabulary video instance segmentation strives to segment and track instances belonging to an open set of categories in a video. The vision-language model Contrastive Language-Image Pre-training (CLIP) has shown strong zero-shot classification ability in image-level open-vocabulary task. In this paper, we propose a simple encoder-decoder network, called CLIP-VIS, to adapt CLIP for open-vocabulary video instance segmentation. Our CLIP-VIS adopts frozen CLIP image encoder and introduces three modules, including class-agnostic mask generation, temporal topK-enhanced matching, and weighted open-vocabulary classification. Given a set of initial queries, class-agnostic mask generation employs a transformer decoder to predict query masks and corresponding object scores and mask IoU scores. Then, temporal topK-enhanced matching performs query matching across frames by using K mostly matched frames. Finally, weighted open-vocabulary classification first generates query visual features with mask pooling, and second performs weighted classification using object scores and mask IoU scores. Our CLIP-VIS does not require the annotations of instance categories and identities. The experiments are performed on various video instance segmentation datasets, which demonstrate the effectiveness of our proposed method, especially on novel categories. When using ConvNeXt-B as backbone, our CLIP-VIS achieves the AP and APn scores of 32.1% and 40.3% on validation set of LV-VIS dataset, which outperforms OV2Seg by 11.0% and 24.0% respectively. We will release the source code and models at https://github.com/zwq456/CLIP-VIS.git.

Sparse-Dense Subspace Clustering

Subspace clustering refers to the problem of clustering high-dimensional data into a union of low-dimensional subspaces. Current subspace clustering approaches are usually based on a two-stage framework. In the first stage, an affinity matrix is generated from data. In the second one, spectral clustering is applied on the affinity matrix. However, the affinity matrix produced by two-stage methods cannot fully reveal the similarity between data points from the same subspace (intra-subspace similarity), resulting in inaccurate clustering. Besides, most approaches fail to solve large-scale clustering problems due to poor efficiency. In this paper, we first propose a new scalable sparse method called Iterative Maximum Correlation (IMC) to learn the affinity matrix from data. Then we develop Piecewise Correlation Estimation (PCE) to densify the intra-subspace similarity produced by IMC. Finally we extend our work into a Sparse-Dense Subspace Clustering (SDSC) framework with a dense stage to optimize the affinity matrix for two-stage methods. We show that IMC is efficient when clustering large-scale data, and PCE ensures better performance for IMC. We show the universality of our SDSC framework as well. Experiments on several data sets demonstrate the effectiveness of our approaches. Moreover, we are the first one to apply densification on affinity matrix before spectral clustering, and SDSC constitutes the first attempt to build a universal three-stage subspace clustering framework.

Residual Encoder-Decoder Network for Deep Subspace Clustering

Subspace clustering aims to cluster unlabeled data that lies in a union of low-dimensional linear subspaces. Deep subspace clustering approaches based on auto-encoders have become very popular to solve subspace clustering problems. However, the training of current deep methods converges slowly, which is much less efficient than traditional approaches. We propose a Residual Encoder-Decoder network for deep Subspace Clustering (RED-SC), which symmetrically links convolutional and deconvolutional layers with skip-layer connections, with which the training converges much faster. We use a self-expressive layer to generate more accurate linear representation coefficients through different latent representations from multiple latent spaces. Experiments show the superiority of RED-SC in training efficiency and clustering accuracy. Moreover, we are the first one to apply residual encoder-decoder on unsupervised learning tasks.

Three-Stage Subspace Clustering Framework with Graph-Based Transformation and Optimization

Subspace clustering (SC) refers to the problem of clustering high-dimensional data into a union of low-dimensional subspaces. Based on spectral clustering, state-of-the-art approaches solve SC problem within a two-stage framework. In the first stage, data representation techniques are applied to draw an affinity matrix from the original data. In the second stage, spectral clustering is directly applied to the affinity matrix so that data can be grouped into different subspaces. However, the affinity matrix obtained in the first stage usually fails to reveal the authentic relationship between data points, which leads to inaccurate clustering results. In this paper, we propose a universal Three-Stage Subspace Clustering framework (3S-SC). Graph-Based Transformation and Optimization (GBTO) is added between data representation and spectral clustering. The affinity matrix is obtained in the first stage, then it goes through the second stage, where the proposed GBTO is applied to generate a reconstructed affinity matrix with more authentic similarity between data points. Spectral clustering is applied after GBTO, which is the third stage. We verify our 3S-SC framework with GBTO through theoretical analysis. Experiments on both synthetic data and the real-world data sets of handwritten digits and human faces demonstrate the universality of the proposed 3S-SC framework in improving the connectivity and accuracy of SC methods based on $\ell_0$, $\ell_1$, $\ell_2$ or nuclear norm regularization.

Restricted Connection Orthogonal Matching Pursuit For Sparse Subspace Clustering

Sparse Subspace Clustering (SSC) is one of the most popular methods for clustering data points into their underlying subspaces. However, SSC may suffer from heavy computational burden. Orthogonal Matching Pursuit applied on SSC accelerates the computation but the trade-off is the loss of clustering accuracy. In this paper, we propose a noise-robust algorithm, Restricted Connection Orthogonal Matching Pursuit for Sparse Subspace Clustering (RCOMP-SSC), to improve the clustering accuracy and maintain the low computational time by restricting the number of connections of each data point during the iteration of OMP. Also, we develop a framework of control matrix to realize RCOMP-SCC. And the framework is scalable for other data point selection strategies. Our analysis and experiments on synthetic data and two real-world databases (EYaleB & Usps) demonstrate the superiority of our algorithm compared with other clustering methods in terms of accuracy and computational time.