Unified Restoration-Perception Learning: Maritime Infrared-Visible Image Fusion and Segmentation

Marine scene understanding and segmentation plays a vital role in maritime monitoring and navigation safety. However, prevalent factors like fog and strong reflections in maritime environments cause severe image degradation, significantly compromising the stability of semantic perception. Existing restoration and enhancement methods typically target specific degradations or focus solely on visual quality, lacking end-to-end collaborative mechanisms that simultaneously improve structural recovery and semantic effectiveness. Moreover, publicly available infrared-visible datasets are predominantly collected from urban scenes, failing to capture the authentic characteristics of coupled degradations in marine environments. To address these challenges, the Infrared-Visible Maritime Ship Dataset (IVMSD) is proposed to cover various maritime scenarios under diverse weather and illumination conditions. Building upon this dataset, a Multi-task Complementary Learning Framework (MCLF) is proposed to collaboratively perform image restoration, multimodal fusion, and semantic segmentation within a unified architecture. The framework includes a Frequency-Spatial Enhancement Complementary (FSEC) module for degradation suppression and structural enhancement, a Semantic-Visual Consistency Attention (SVCA) module for semantic-consistent guidance, and a cross-modality guided attention mechanism for selective fusion. Experimental results on IVMSD demonstrate that the proposed method achieves state-of-the-art segmentation performance, significantly enhancing robustness and perceptual quality under complex maritime conditions.

PhenoProfiler: Advancing Phenotypic Learning for Image-based Drug Discovery

In the field of image-based drug discovery, capturing the phenotypic response of cells to various drug treatments and perturbations is a crucial step. However, existing methods require computationally extensive and complex multi-step procedures, which can introduce inefficiencies, limit generalizability, and increase potential errors. To address these challenges, we present PhenoProfiler, an innovative model designed to efficiently and effectively extract morphological representations, enabling the elucidation of phenotypic changes induced by treatments. PhenoProfiler is designed as an end-to-end tool that processes whole-slide multi-channel images directly into low-dimensional quantitative representations, eliminating the extensive computational steps required by existing methods. It also includes a multi-objective learning module to enhance robustness, accuracy, and generalization in morphological representation learning. PhenoProfiler is rigorously evaluated on large-scale publicly available datasets, including over 230,000 whole-slide multi-channel images in end-to-end scenarios and more than 8.42 million single-cell images in non-end-to-end settings. Across these benchmarks, PhenoProfiler consistently outperforms state-of-the-art methods by up to 20%, demonstrating substantial improvements in both accuracy and robustness. Furthermore, PhenoProfiler uses a tailored phenotype correction strategy to emphasize relative phenotypic changes under treatments, facilitating the detection of biologically meaningful signals. UMAP visualizations of treatment profiles demonstrate PhenoProfiler ability to effectively cluster treatments with similar biological annotations, thereby enhancing interpretability. These findings establish PhenoProfiler as a scalable, generalizable, and robust tool for phenotypic learning.