High-Quality Medical Image Generation from Free-hand Sketch

Generating medical images from human-drawn free-hand sketches holds promise for various important medical imaging applications. Due to the extreme difficulty in collecting free-hand sketch data in the medical domain, most deep learning-based methods have been proposed to generate medical images from the synthesized sketches (e.g., edge maps or contours of segmentation masks from real images). However, these models often fail to generalize on the free-hand sketches, leading to unsatisfactory results. In this paper, we propose a practical free-hand sketch-to-image generation model called Sketch2MedI that learns to represent sketches in StyleGAN's latent space and generate medical images from it. Thanks to the ability to encode sketches into this meaningful representation space, Sketch2MedI only requires synthesized sketches for training, enabling a cost-effective learning process. Our Sketch2MedI demonstrates a robust generalization to free-hand sketches, resulting in high-quality and realistic medical image generations. Comparative evaluations of Sketch2MedI against the pix2pix, CycleGAN, UNIT, and U-GAT-IT models show superior performance in generating pharyngeal images, both quantitative and qualitative across various metrics.

Towards Robust Plant Disease Diagnosis with Hard-sample Re-mining Strategy

With rich annotation information, object detection-based automated plant disease diagnosis systems (e.g., YOLO-based systems) often provide advantages over classification-based systems (e.g., EfficientNet-based), such as the ability to detect disease locations and superior classification performance. One drawback of these detection systems is dealing with unannotated healthy data with no real symptoms present. In practice, healthy plant data appear to be very similar to many disease data. Thus, those models often produce mis-detected boxes on healthy images. In addition, labeling new data for detection models is typically time-consuming. Hard-sample mining (HSM) is a common technique for re-training a model by using the mis-detected boxes as new training samples. However, blindly selecting an arbitrary amount of hard-sample for re-training will result in the degradation of diagnostic performance for other diseases due to the high similarity between disease and healthy data. In this paper, we propose a simple but effective training strategy called hard-sample re-mining (HSReM), which is designed to enhance the diagnostic performance of healthy data and simultaneously improve the performance of disease data by strategically selecting hard-sample training images at an appropriate level. Experiments based on two practical in-field eight-class cucumber and ten-class tomato datasets (42.7K and 35.6K images) show that our HSReM training strategy leads to a substantial improvement in the overall diagnostic performance on large-scale unseen data. Specifically, the object detection model trained using the HSReM strategy not only achieved superior results as compared to the classification-based state-of-the-art EfficientNetV2-Large model and the original object detection model, but also outperformed the model using the HSM strategy.

A Practical Framework for Unsupervised Structure Preservation Medical Image Enhancement

Medical images are extremely valuable for supporting medical diagnoses. However, in practice, low-quality (LQ) medical images, such as images that are hazy/blurry, have uneven illumination, or are out of focus, among others, are often obtained during data acquisition. This leads to difficulties in the screening and diagnosis of medical diseases. Several generative adversarial networks (GAN)-based image enhancement methods have been proposed and have shown promising results. However, there is a quality-originality trade-off among these methods in the sense that they produce visually pleasing results but lose the ability to preserve originality, especially the structural inputs. Moreover, to our knowledge, there is no objective metric in evaluating the structure preservation of medical image enhancement methods in unsupervised settings due to the unavailability of paired ground-truth data. In this study, we propose a framework for practical unsupervised medical image enhancement that includes (1) a non-reference objective evaluation of structure preservation for medical image enhancement tasks called Laplacian structural similarity index measure (LaSSIM), which is based on SSIM and the Laplacian pyramid, and (2) a novel unsupervised GAN-based method called Laplacian medical image enhancement (LaMEGAN) to support the improvement of both originality and quality from LQ images. The LaSSIM metric does not require clean reference images and has been shown to be superior to SSIM in capturing image structural changes under image degradations, such as strong blurring on different datasets. The experiments demonstrated that our LaMEGAN achieves a satisfactory balance between quality and originality, with robust structure preservation performance while generating compelling visual results with very high image quality scores. The code will be made available at https://github.com/AillisInc/USPMIE.

Bulk Production Augmentation Towards Explainable Melanoma Diagnosis

Although highly accurate automated diagnostic techniques for melanoma have been reported, the realization of a system capable of providing diagnostic evidence based on medical indices remains an open issue because of difficulties in obtaining reliable training data. In this paper, we propose bulk production augmentation (BPA) to generate high-quality, diverse pseudo-skin tumor images with the desired structural malignant features for additional training images from a limited number of labeled images. The proposed BPA acts as an effective data augmentation in constructing the feature detector for the atypical pigment network (APN), which is a key structure in melanoma diagnosis. Experiments show that training with images generated by our BPA largely boosts the APN detection performance by 20.0 percentage points in the area under the receiver operating characteristic curve, which is 11.5 to 13.7 points higher than that of conventional CycleGAN-based augmentations in AUC.

MIINet: An Image Quality Improvement Framework for Supporting Medical Diagnosis

Medical images have been indispensable and useful tools for supporting medical experts in making diagnostic decisions. However, taken medical images especially throat and endoscopy images are normally hazy, lack of focus, or uneven illumination. Thus, these could difficult the diagnosis process for doctors. In this paper, we propose MIINet, a novel image-to-image translation network for improving quality of medical images by unsupervised translating low-quality images to the high-quality clean version. Our MIINet is not only capable of generating high-resolution clean images, but also preserving the attributes of original images, making the diagnostic more favorable for doctors. Experiments on dehazing 100 practical throat images show that our MIINet largely improves the mean doctor opinion score (MDOS), which assesses the quality and the reproducibility of the images from the baseline of 2.36 to 4.11, while dehazed images by CycleGAN got lower score of 3.83. The MIINet is confirmed by three physicians to be satisfying in supporting throat disease diagnostic from original low-quality images.

LASSR: Effective Super-Resolution Method for Plant Disease Diagnosis

The collection of high-resolution training data is crucial in building robust plant disease diagnosis systems, since such data have a significant impact on diagnostic performance. However, they are very difficult to obtain and are not always available in practice. Deep learning-based techniques, and particularly generative adversarial networks (GANs), can be applied to generate high-quality super-resolution images, but these methods often produce unexpected artifacts that can lower the diagnostic performance. In this paper, we propose a novel artifact-suppression super-resolution method that is specifically designed for diagnosing leaf disease, called Leaf Artifact-Suppression Super Resolution (LASSR). Thanks to its own artifact removal module that detects and suppresses artifacts to a considerable extent, LASSR can generate much more pleasing, high-quality images compared to the state-of-the-art ESRGAN model. Experiments based on a five-class cucumber disease (including healthy) discrimination model show that training with data generated by LASSR significantly boosts the performance on an unseen test dataset by nearly 22% compared with the baseline, and that our approach is more than 2% better than a model trained with images generated by ESRGAN.

LeafGAN: An Effective Data Augmentation Method for Practical Plant Disease Diagnosis

Many applications for the automated diagnosis of plant disease have been developed based on the success of deep learning techniques. However, these applications often suffer from overfitting, and the diagnostic performance is drastically decreased when used on test datasets from new environments. The typical reasons for this are that the symptoms to be detected are unclear or faint, and there are limitations related to data diversity. In this paper, we propose LeafGAN, a novel image-to-image translation system with own attention mechanism. LeafGAN generates a wide variety of diseased images via transformation from healthy images, as a data augmentation tool for improving the performance of plant disease diagnosis. Thanks to its own attention mechanism, our model can transform only relevant areas from images with a variety of backgrounds, thus enriching the versatility of the training images. Experiments with five-class cucumber disease classification show that data augmentation with vanilla CycleGAN cannot help to improve the generalization, i.e. disease diagnostic performance increased by only 0.7% from the baseline. In contrast, LeafGAN boosted the diagnostic performance by 7.4%. We also visually confirmed the generated images by our LeafGAN were much better quality and more convincing than those generated by vanilla CycleGAN.

Super-Resolution for Practical Automated Plant Disease Diagnosis System

Automated plant diagnosis using images taken from a distance is often insufficient in resolution and degrades diagnostic accuracy since the important external characteristics of symptoms are lost. In this paper, we first propose an effective pre-processing method for improving the performance of automated plant disease diagnosis systems using super-resolution techniques. We investigate the efficiency of two different super-resolution methods by comparing the disease diagnostic performance on the practical original high-resolution, low-resolution, and super-resolved cucumber images. Our method generates super-resolved images that look very close to natural images with 4$\times$ upscaling factors and is capable of recovering the lost detailed symptoms, largely boosting the diagnostic performance. Our model improves the disease classification accuracy by 26.9% over the bicubic interpolation method of 65.6% and shows a small gap (3% lower) between the original result of 95.5%.

AOP: An Anti-overfitting Pretreatment for Practical Image-based Plant Diagnosis

In image-based plant diagnosis, clues related to diagnosis are often unclear, and the other factors such as image backgrounds often have a significant impact on the final decision. As a result, overfitting due to latent similarities in the dataset often occurs, and the diagnostic performance on real unseen data (e,g. images from other farms) is usually dropped significantly. However, this problem has not been sufficiently explored, since many systems have shown excellent diagnostic performance due to the bias caused by the similarities in the dataset. In this study, we investigate this problem with experiments using more than 50,000 images of cucumber leaves, and propose an anti-overfitting pretreatment (AOP) for realizing practical image-based plant diagnosis systems. The AOP detects the area of interest (leaf, fruit etc.) and performs brightness calibration as a preprocessing step. The experimental results demonstrate that our AOP can improve the accuracy of diagnosis for unknown test images from different farms by 12.2% in a practical setting.

A comparable study: Intrinsic difficulties of practical plant diagnosis from wide-angle images

Practical automated detection and diagnosis of plant disease from wide-angle images (i.e. in-field images containing multiple leaves using a fixed-position camera) is a very important application for large-scale farm management, in view of the need to ensure global food security. However, developing automated systems for disease diagnosis is often difficult, because labeling a reliable wide-angle disease dataset from actual field images is very laborious. In addition, the potential similarities between the training and test data lead to a serious problem of model overfitting. In this paper, we investigate changes in performance when applying disease diagnosis systems to different scenarios involving wide-angle cucumber test data captured on real farms, and propose an effective diagnostic strategy. We show that leading object recognition techniques such as SSD and Faster R-CNN achieve excellent end-to-end disease diagnostic performance only for a test dataset that is collected from the same population as the training dataset (with F1-score of 81.5% - 84.1% for diagnosed cases of disease), but their performance markedly deteriorates for a completely different test dataset (with F1-score of 4.4 - 6.2%). In contrast, our proposed two-stage systems using independent leaf detection and leaf diagnosis stages attain a promising disease diagnostic performance that is more than six times higher than end-to-end systems (with F1-score of 33.4 - 38.9%) on an unseen target dataset. We also confirm the efficiency of our proposal based on visual assessment, concluding that a two-stage model is a suitable and reasonable choice for practical applications.