Naturalistic Language-related Movie-Watching fMRI Task for Detecting Neurocognitive Decline and Disorder

Early detection is crucial for timely intervention aimed at preventing and slowing the progression of neurocognitive disorder (NCD), a common and significant health problem among the aging population. Recent evidence has suggested that language-related functional magnetic resonance imaging (fMRI) may be a promising approach for detecting cognitive decline and early NCD. In this paper, we proposed a novel, naturalistic language-related fMRI task for this purpose. We examined the effectiveness of this task among 97 non-demented Chinese older adults from Hong Kong. The results showed that machine-learning classification models based on fMRI features extracted from the task and demographics (age, gender, and education year) achieved an average area under the curve of 0.86 when classifying participants' cognitive status (labeled as NORMAL vs DECLINE based on their scores on a standard neurcognitive test). Feature localization revealed that the fMRI features most frequently selected by the data-driven approach came primarily from brain regions associated with language processing, such as the superior temporal gyrus, middle temporal gyrus, and right cerebellum. The study demonstrated the potential of the naturalistic language-related fMRI task for early detection of aging-related cognitive decline and NCD.

A Study of Data-driven Methods for Inventory Optimization

This paper shows a comprehensive analysis of three algorithms (Time Series, Random Forest (RF) and Deep Reinforcement Learning) into three inventory models (the Lost Sales, Dual-Sourcing and Multi-Echelon Inventory Model). These methodologies are applied in the supermarket context. The main purpose is to analyse efficient methods for the data-driven. Their possibility, potential and current challenges are taken into consideration in this report. By comparing the results in each model, the effectiveness of each algorithm is evaluated based on several key performance indicators, including forecast accuracy, adaptability to market changes, and overall impact on inventory costs and customer satisfaction levels. The data visualization tools and statistical metrics are the indicators for the comparisons and show some obvious trends and patterns that can guide decision-making in inventory management. These tools enable managers to not only track the performance of different algorithms in real-time but also to drill down into specific data points to understand the underlying causes of inventory fluctuations. This level of detail is crucial for pinpointing inefficiencies and areas for improvement within the supply chain.

Detecting Neurocognitive Disorders through Analyses of Topic Evolution and Cross-modal Consistency in Visual-Stimulated Narratives

Early detection of neurocognitive disorders (NCDs) is crucial for timely intervention and disease management. Speech analysis offers a non-intrusive and scalable screening method, particularly through narrative tasks in neuropsychological assessment tools. Traditional narrative analysis often focuses on local indicators in microstructure, such as word usage and syntax. While these features provide insights into language production abilities, they often fail to capture global narrative patterns, or microstructures. Macrostructures include coherence, thematic organization, and logical progressions, reflecting essential cognitive skills potentially critical for recognizing NCDs. Addressing this gap, we propose to investigate specific cognitive and linguistic challenges by analyzing topical shifts, temporal dynamics, and the coherence of narratives over time, aiming to reveal cognitive deficits by identifying narrative impairments, and exploring their impact on communication and cognition. The investigation is based on the CU-MARVEL Rabbit Story corpus, which comprises recordings of a story-telling task from 758 older adults. We developed two approaches: the Dynamic Topic Models (DTM)-based temporal analysis to examine the evolution of topics over time, and the Text-Image Temporal Alignment Network (TITAN) to evaluate the coherence between spoken narratives and visual stimuli. DTM-based approach validated the effectiveness of dynamic topic consistency as a macrostructural metric (F1=0.61, AUC=0.78). The TITAN approach achieved the highest performance (F1=0.72, AUC=0.81), surpassing established microstructural and macrostructural feature sets. Cross-comparison and regression tasks further demonstrated the effectiveness of proposed dynamic macrostructural modeling approaches for NCD detection.