Reinforcement Learning for Large Language Model Selective Evidence Adoption from Contaminated Retrieval Results

Retrieval-augmented large language models frequently face contexts that interleave useful evidence with misleading statements or instruction-like content. Blanket refusal discards valid evidence, whereas uncritical adoption yields incorrect or unsafe answers. The ability to selectively adopt relevant information while rejecting deceptive or harmful content is therefore critical for reliable deployment in real-world retrieval settings. We introduce SelectBench, a controlled benchmark and training set for selective evidence adoption, and post-train Qwen3.5-4B directly with DAPO using either deterministic rule rewards or a frozen semantic judge. On the corrected 325-example SelectBench-v2 test set, strict success rises from 22.46% for the original checkpoint to 25.54% with DAPO-Rule and 26.46% with DAPO-DeepSeek. Both trained policies reduce forbidden-content adoption and produce shorter, more focused responses, yet prompt-injection following does not improve. The paired gains are modest and fail to survive Holm correction, suggesting that stronger reward shaping or additional training iterations may be needed for more robust gains. DAPO-DeepSeek exhibits no material degradation on MMLU or clean HotpotQA, indicating that the post-training procedure preserves general capabilities. These results demonstrate a directional improvement in selective evidence use, while identifying injection resistance and statistical robustness as important remaining challenges for future work.

Comprehensive evaluation of deep and graph learning on drug-drug interactions prediction

Recent advances and achievements of artificial intelligence (AI) as well as deep and graph learning models have established their usefulness in biomedical applications, especially in drug-drug interactions (DDIs). DDIs refer to a change in the effect of one drug to the presence of another drug in the human body, which plays an essential role in drug discovery and clinical research. DDIs prediction through traditional clinical trials and experiments is an expensive and time-consuming process. To correctly apply the advanced AI and deep learning, the developer and user meet various challenges such as the availability and encoding of data resources, and the design of computational methods. This review summarizes chemical structure based, network based, NLP based and hybrid methods, providing an updated and accessible guide to the broad researchers and development community with different domain knowledge. We introduce widely-used molecular representation and describe the theoretical frameworks of graph neural network models for representing molecular structures. We present the advantages and disadvantages of deep and graph learning methods by performing comparative experiments. We discuss the potential technical challenges and highlight future directions of deep and graph learning models for accelerating DDIs prediction.