Blend the Separated: Mixture of Synergistic Experts for Data-Scarcity Drug-Target Interaction Prediction

Drug-target interaction prediction (DTI) is essential in various applications including drug discovery and clinical application. There are two perspectives of input data widely used in DTI prediction: Intrinsic data represents how drugs or targets are constructed, and extrinsic data represents how drugs or targets are related to other biological entities. However, any of the two perspectives of input data can be scarce for some drugs or targets, especially for those unpopular or newly discovered. Furthermore, ground-truth labels for specific interaction types can also be scarce. Therefore, we propose the first method to tackle DTI prediction under input data and/or label scarcity. To make our model functional when only one perspective of input data is available, we design two separate experts to process intrinsic and extrinsic data respectively and fuse them adaptively according to different samples. Furthermore, to make the two perspectives complement each other and remedy label scarcity, two experts synergize with each other in a mutually supervised way to exploit the enormous unlabeled data. Extensive experiments on 3 real-world datasets under different extents of input data scarcity and/or label scarcity demonstrate our model outperforms states of the art significantly and steadily, with a maximum improvement of 53.53%. We also test our model without any data scarcity and it still outperforms current methods.

BaiJia: A Large Scale Role-Playing Agent Corpus of Chinese Historical Charcaters

We introduce a comprehensive large-scale role-playing agent corpus, termed BaiJia, that comprises various Chinese historical characters. This corpus is noteworthy for being the pioneering compilation of low-resource data that can be utilized in large language models (LLMs) to engage in AI-driven historical role-playing agents. BaiJia addresses the challenges in terms of fragmented historical textual records in different forms and modalities, integrating various characters' information, including their biographical, literary, family relations, historical events, and so on. We conduct extensive experiments to demonstrate the effectiveness of our BaiJia agent corpus in bolstering the role-playing abilities of various foundational LLMs, and promoting the development and assessment of LLMs in the context of historical role-playing tasks. The agent corpus is available at baijia.online.