Improved Multiscale Structural Mapping with Supervertex Vision Transformer for the Detection of Alzheimer's Disease Neurodegeneration

Alzheimer's disease (AD) confirmation often relies on positron emission tomography (PET) or cerebrospinal fluid (CSF) analysis, which are costly and invasive. Consequently, structural MRI biomarkers such as cortical thickness (CT) are widely used for non-invasive AD screening. Multiscale structural mapping (MSSM) was recently proposed to integrate gray-white matter contrasts (GWCs) with CT from a single T1-weighted MRI (T1w) scan. Building on this framework, we propose MSSM+, together with surface supervertex mapping (SSVM) and a Supervertex Vision Transformer (SV-ViT). 3D T1w images from individuals with AD and cognitively normal (CN) controls were analyzed. MSSM+ extends MSSM by incorporating sulcal depth and cortical curvature at the vertex level. SSVM partitions the cortical surface into supervertices (surface patches) that effectively represent inter- and intra-regional spatial relationships. SV-ViT is a Vision Transformer architecture operating on these supervertices, enabling anatomically informed learning from surface mesh representations. Compared with MSSM, MSSM+ identified more spatially extensive and statistically significant group differences between AD and CN. In AD vs. CN classification, MSSM+ achieved a 3%p higher area under the precision-recall curve than MSSM. Vendor-specific analyses further demonstrated reduced signal variability and consistently improved classification performance across MR manufacturers relative to CT, GWCs, and MSSM. These findings suggest that MSSM+ combined with SV-ViT is a promising MRI-based imaging marker for AD detection prior to CSF/PET confirmation.

ADP-DiT: Text-Guided Diffusion Transformer for Brain Image Generation in Alzheimer's Disease Progression

Alzheimer's disease (AD) progresses heterogeneously across individuals, motivating subject-specific synthesis of follow-up magnetic resonance imaging (MRI) to support progression assessment. While Diffusion Transformers (DiT), an emerging transformer-based diffusion model, offer a scalable backbone for image synthesis, longitudinal AD MRI generation with clinically interpretable control over follow-up time and participant metadata remains underexplored. We present ADP-DiT, an interval-aware, clinically text-conditioned diffusion transformer for longitudinal AD MRI synthesis. ADP-DiT encodes follow-up interval together with multi-domain demographic, diagnostic (CN/MCI/AD), and neuropsychological information as a natural-language prompt, enabling time-specific control beyond coarse diagnostic stages. To inject this conditioning effectively, we use dual text encoders-OpenCLIP for vision-language alignment and T5 for richer clinical-language understanding. Their embeddings are fused into DiT through cross-attention for fine-grained guidance and adaptive layer normalization for global modulation. We further enhance anatomical fidelity by applying rotary positional embeddings to image tokens and performing diffusion in a pre-trained SDXL-VAE latent space to enable efficient high-resolution reconstruction. On 3,321 longitudinal 3T T1-weighted scans from 712 participants (259,038 image slices), ADP-DiT achieves SSIM 0.8739 and PSNR 29.32 dB, improving over a DiT baseline by +0.1087 SSIM and +6.08 dB PSNR while capturing progression-related changes such as ventricular enlargement and shrinking hippocampus. These results suggest that integrating comprehensive, subject-specific clinical conditions with architectures can improve longitudinal AD MRI synthesis.

MedROI: Codec-Agnostic Region of Interest-Centric Compression for Medical Images

Medical imaging archives are growing rapidly in both size and resolution, making efficient compression increasingly important for storage and data transfer. Most existing codecs compress full images/volumes(including non-diagnostic background) or apply differential ROI coding that still preserves background bits. We propose MedROI, a codec-agnostic, plug-and-play ROI-centric framework that discards background voxels prior to compression. MedROI extracts a tight tissue bounding box via lightweight intensity-based thresholding and stores a fixed 54byte meta data record to enable spatial restoration during decompression. The cropped ROI is then compressed using any existing 2D or 3D codec without architectural modifications or retraining. We evaluate MedROI on 200 T1-weighted brain MRI volumes from ADNI using 6 codec configurations spanning conventional codecs (JPEG2000 2D/3D, HEIF) and neural compressors (LIC_TCM, TCM+AuxT, BCM-Net, SirenMRI). MedROI yields statistically significant improvements in compression ratio and encoding/decoding time for most configurations (two-sided t-test with multiple-comparison correction), while maintaining comparable reconstruction quality when measured within the ROI; HEIF is the primary exception in compression-ratio gains. For example, on JPEG20002D (lv3), MedROI improves CR from 20.35 to 27.37 while reducing average compression time from 1.701s to 1.380s. Code is available at https://github.com/labhai/MedROI.

Dodgersort: Uncertainty-Aware VLM-Guided Human-in-the-Loop Pairwise Ranking

Pairwise comparison labeling is emerging as it yields higher inter-rater reliability than conventional classification labeling, but exhaustive comparisons require quadratic cost. We propose Dodgersort, which leverages CLIP-based hierarchical pre-ordering, a neural ranking head and probabilistic ensemble (Elo, BTL, GP), epistemic--aleatoric uncertainty decomposition, and information-theoretic pair selection. It reduces human comparisons while improving the reliability of the rankings. In visual ranking tasks in medical imaging, historical dating, and aesthetics, Dodgersort achieves a 11--16\% annotation reduction while improving inter-rater reliability. Cross-domain ablations across four datasets show that neural adaptation and ensemble uncertainty are key to this gain. In FG-NET with ground-truth ages, the framework extracts 5--20$\times$ more ranking information per comparison than baselines, yielding Pareto-optimal accuracy--efficiency trade-offs.

EZ-Sort: Efficient Pairwise Comparison via Zero-Shot CLIP-Based Pre-Ordering and Human-in-the-Loop Sorting

Pairwise comparison is often favored over absolute rating or ordinal classification in subjective or difficult annotation tasks due to its improved reliability. However, exhaustive comparisons require a massive number of annotations (O(n^2)). Recent work has greatly reduced the annotation burden (O(n log n)) by actively sampling pairwise comparisons using a sorting algorithm. We further improve annotation efficiency by (1) roughly pre-ordering items using the Contrastive Language-Image Pre-training (CLIP) model hierarchically without training, and (2) replacing easy, obvious human comparisons with automated comparisons. The proposed EZ-Sort first produces a CLIP-based zero-shot pre-ordering, then initializes bucket-aware Elo scores, and finally runs an uncertainty-guided human-in-the-loop MergeSort. Validation was conducted using various datasets: face-age estimation (FGNET), historical image chronology (DHCI), and retinal image quality assessment (EyePACS). It showed that EZ-Sort reduced human annotation cost by 90.5% compared to exhaustive pairwise comparisons and by 19.8% compared to prior work (when n = 100), while improving or maintaining inter-rater reliability. These results demonstrate that combining CLIP-based priors with uncertainty-aware sampling yields an efficient and scalable solution for pairwise ranking.

BOLDSimNet: Examining Brain Network Similarity between Task and Resting-State fMRI

Traditional causal connectivity methods in task-based and resting-state functional magnetic resonance imaging (fMRI) face challenges in accurately capturing directed information flow due to their sensitivity to noise and inability to model multivariate dependencies. These limitations hinder the effective comparison of brain networks between cognitive states, making it difficult to analyze network reconfiguration during task and resting states. To address these issues, we propose BOLDSimNet, a novel framework utilizing Multivariate Transfer Entropy (MTE) to measure causal connectivity and network similarity across different cognitive states. Our method groups functionally similar regions of interest (ROIs) rather than spatially adjacent nodes, improving accuracy in network alignment. We applied BOLDSimNet to fMRI data from 40 healthy controls and found that children exhibited higher similarity scores between task and resting states compared to adolescents, indicating reduced variability in attention shifts. In contrast, adolescents showed more differences between task and resting states in the Dorsal Attention Network (DAN) and the Default Mode Network (DMN), reflecting enhanced network adaptability. These findings emphasize developmental variations in the reconfiguration of the causal brain network, showcasing BOLDSimNet's ability to quantify network similarity and identify attentional fluctuations between different cognitive states.

Uncertainty-Weighted Mutual Distillation for Multi-View Fusion

Multi-view learning often faces challenges in effectively leveraging images captured from different angles and locations. This challenge is particularly pronounced when addressing inconsistencies and uncertainties between views. In this paper, we propose a novel Multi-View Uncertainty-Weighted Mutual Distillation (MV-UWMD) method. Our method enhances prediction consistency by performing hierarchical mutual distillation across all possible view combinations, including single-view, partial multi-view, and full multi-view predictions. This introduces an uncertainty-based weighting mechanism through mutual distillation, allowing effective exploitation of unique information from each view while mitigating the impact of uncertain predictions. We extend a CNN-Transformer hybrid architecture to facilitate robust feature learning and integration across multiple view combinations. We conducted extensive experiments using a large, unstructured dataset captured from diverse, non-fixed viewpoints. The results demonstrate that MV-UWMD improves prediction accuracy and consistency compared to existing multi-view learning approaches.

Calibration of ordinal regression networks

Recent studies have shown that deep neural networks are not well-calibrated and produce over-confident predictions. The miscalibration issue primarily stems from the minimization of cross-entropy, which aims to align predicted softmax probabilities with one-hot labels. In ordinal regression tasks, this problem is compounded by an additional challenge: the expectation that softmax probabilities should exhibit unimodal distribution is not met with cross-entropy. Rather, the ordinal regression literature has focused on unimodality and overlooked calibration. To address these issues, we propose a novel loss function that introduces order-aware calibration, ensuring that prediction confidence adheres to ordinal relationships between classes. It incorporates soft ordinal encoding and label-smoothing-based regularization to enforce both calibration and unimodality. Extensive experiments across three popular ordinal regression benchmarks demonstrate that our approach achieves state-of-the-art calibration without compromising accuracy.

Weakly Supervised Pretraining and Multi-Annotator Supervised Finetuning for Facial Wrinkle Detection

1. Research question: With the growing interest in skin diseases and skin aesthetics, the ability to predict facial wrinkles is becoming increasingly important. This study aims to evaluate whether a computational model, convolutional neural networks (CNN), can be trained for automated facial wrinkle segmentation. 2. Findings: Our study presents an effective technique for integrating data from multiple annotators and illustrates that transfer learning can enhance performance, resulting in dependable segmentation of facial wrinkles. 3. Meaning: This approach automates intricate and time-consuming tasks of wrinkle analysis with a deep learning framework. It could be used to facilitate skin treatments and diagnostics.

Facial Wrinkle Segmentation for Cosmetic Dermatology: Pretraining with Texture Map-Based Weak Supervision

Facial wrinkle detection plays a crucial role in cosmetic dermatology. Precise manual segmentation of facial wrinkles is challenging and time-consuming, with inherent subjectivity leading to inconsistent results among graders. To address this issue, we propose two solutions. First, we build and release the first public facial wrinkle dataset, `FFHQ-Wrinkle', an extension of the NVIDIA FFHQ dataset. This dataset includes 1,000 images with human labels and 50,000 images with automatically generated weak labels. This dataset can foster the research community to develop advanced wrinkle detection algorithms. Second, we introduce a training strategy for U-Net-like encoder-decoder models to detect wrinkles across the face automatically. Our method employs a two-stage training strategy: texture map pretraining and finetuning on human-labeled data. Initially, we pretrain models on a large dataset with weak labels (N=50k) or masked texture maps generated through computer vision techniques, without human intervention. Subsequently, we finetune the models using human-labeled data (N=1k), which consists of manually labeled wrinkle masks. During finetuning, the network inputs a combination of RGB and masked texture maps, comprising four channels. We effectively combine labels from multiple annotators to minimize subjectivity in manual labeling. Our strategies demonstrate improved segmentation performance in facial wrinkle segmentation both quantitatively and visually compared to existing pretraining methods.