Beyond 1D: Vision Transformers and Multichannel Signal Images for PPG-to-ECG Reconstruction

Reconstructing ECG from PPG is a promising yet challenging task. While recent advancements in generative models have significantly improved ECG reconstruction, accurately capturing fine-grained waveform features remains a key challenge. To address this, we propose a novel PPG-to-ECG reconstruction method that leverages a Vision Transformer (ViT) as the core network. Unlike conventional approaches that rely on single-channel PPG, our method employs a four-channel signal image representation, incorporating the original PPG, its first-order difference, second-order difference, and area under the curve. This multi-channel design enriches feature extraction by preserving both temporal and physiological variations within the PPG. By leveraging the self-attention mechanism in ViT, our approach effectively captures both inter-beat and intra-beat dependencies, leading to more robust and accurate ECG reconstruction. Experimental results demonstrate that our method consistently outperforms existing 1D convolution-based approaches, achieving up to 29% reduction in PRD and 15% reduction in RMSE. The proposed approach also produces improvements in other evaluation metrics, highlighting its robustness and effectiveness in reconstructing ECG signals. Furthermore, to ensure a clinically relevant evaluation, we introduce new performance metrics, including QRS area error, PR interval error, RT interval error, and RT amplitude difference error. Our findings suggest that integrating a four-channel signal image representation with the self-attention mechanism of ViT enables more effective extraction of informative PPG features and improved modeling of beat-to-beat variations for PPG-to-ECG mapping. Beyond demonstrating the potential of PPG as a viable alternative for heart activity monitoring, our approach opens new avenues for cyclic signal analysis and prediction.

CLEP-GAN: An Innovative Approach to Subject-Independent ECG Reconstruction from PPG Signals

This study addresses the challenge of reconstructing unseen ECG signals from PPG signals, a critical task for non-invasive cardiac monitoring. While numerous public ECG-PPG datasets are available, they lack the diversity seen in image datasets, and data collection processes often introduce noise, complicating ECG reconstruction from PPG even with advanced machine learning models. To tackle these challenges, we first introduce a novel synthetic ECG-PPG data generation technique using an ODE model to enhance training diversity. Next, we develop a novel subject-independent PPG-to-ECG reconstruction model that integrates contrastive learning, adversarial learning, and attention gating, achieving results comparable to or even surpassing existing approaches for unseen ECG reconstruction. Finally, we examine factors such as sex and age that impact reconstruction accuracy, emphasizing the importance of considering demographic diversity during model training and dataset augmentation.

Multi-objective optimization and explanation for stroke risk assessment in Shanxi province

Stroke is the top leading causes of death in China (Zhou et al. The Lancet 2019). A dataset from Shanxi Province is used to identify the risk of each patient's at four states low/medium/high/attack and provide the state transition tendency through a SHAP DeepExplainer. To improve the accuracy on an imbalance sample set, the Quadratic Interactive Deep Neural Network (QIDNN) model is first proposed by flexible selecting and appending of quadratic interactive features. The experimental results showed that the QIDNN model with 7 interactive features achieve the state-of-art accuracy $83.25\%$. Blood pressure, physical inactivity, smoking, weight and total cholesterol are the top five important features. Then, for the sake of high recall on the most urgent state, attack state, the stroke occurrence prediction is taken as an auxiliary objective to benefit from multi-objective optimization. The prediction accuracy was promoted, meanwhile the recall of the attack state was improved by $24.9\%$ (to $84.83\%$) compared to QIDNN (from $67.93\%$) with same features. The prediction model and analysis tool in this paper not only gave the theoretical optimized prediction method, but also provided the attribution explanation of risk states and transition direction of each patient, which provided a favorable tool for doctors to analyze and diagnose the disease.

Analysis and classification of main risk factors causing stroke in Shanxi Province

In China, stroke is the first leading cause of death in recent years. It is a major cause of long-term physical and cognitive impairment, which bring great pressure on the National Public Health System. Evaluation of the risk of getting stroke is important for the prevention and treatment of stroke in China. A data set with 2000 hospitalized stroke patients in 2018 and 27583 residents during the year 2017 to 2020 is analyzed in this study. Due to data incompleteness, inconsistency, and non-structured formats, missing values in the raw data are filled with -1 as an abnormal class. With the cleaned features, three models on risk levels of getting stroke are built by using machine learning methods. The importance of "8+2" factors from China National Stroke Prevention Project (CSPP) is evaluated via decision tree and random forest models. Except for "8+2" factors the importance of features and SHAP1 values for lifestyle information, demographic information, and medical measurement are evaluated and ranked via a random forest model. Furthermore, a logistic regression model is applied to evaluate the probability of getting stroke for different risk levels. Based on the census data in both communities and hospitals from Shanxi Province, we investigate different risk factors of getting stroke and their ranking with interpretable machine learning models. The results show that Hypertension (Systolic blood pressure, Diastolic blood pressure), Physical Inactivity (Lack of sports), and Overweight (BMI) are ranked as the top three high-risk factors of getting stroke in Shanxi province. The probability of getting stroke for a person can also be predicted via our machine learning model.