MyoPS: A Benchmark of Myocardial Pathology Segmentation Combining Three-Sequence Cardiac Magnetic Resonance Images

Assessment of myocardial viability is essential in diagnosis and treatment management of patients suffering from myocardial infarction, and classification of pathology on myocardium is the key to this assessment. This work defines a new task of medical image analysis, i.e., to perform myocardial pathology segmentation (MyoPS) combining three-sequence cardiac magnetic resonance (CMR) images, which was first proposed in the MyoPS challenge, in conjunction with MICCAI 2020. The challenge provided 45 paired and pre-aligned CMR images, allowing algorithms to combine the complementary information from the three CMR sequences for pathology segmentation. In this article, we provide details of the challenge, survey the works from fifteen participants and interpret their methods according to five aspects, i.e., preprocessing, data augmentation, learning strategy, model architecture and post-processing. In addition, we analyze the results with respect to different factors, in order to examine the key obstacles and explore potential of solutions, as well as to provide a benchmark for future research. We conclude that while promising results have been reported, the research is still in the early stage, and more in-depth exploration is needed before a successful application to the clinics. Note that MyoPS data and evaluation tool continue to be publicly available upon registration via its homepage (www.sdspeople.fudan.edu.cn/zhuangxiahai/0/myops20/).

LE-NAS: Learning-based Ensenble with NAS for Dose Prediction

Radiation therapy treatment planning is a complex process, as the target dose prescription and normal tissue sparing are conflicting objectives. Automated and accurate dose prediction for radiation therapy planning is in high demand. In this study, we propose a novel learning-based ensemble approach, named LE-NAS, which integrates neural architecture search (NAS) with knowledge distillation for 3D radiotherapy dose prediction. Specifically, the prediction network first exhaustively searches each block from enormous architecture space. Then, multiple architectures are selected with promising performance and diversity. To reduce the inference time, we adopt the teacher-student paradigm by treating the combination of diverse outputs from multiple searched networks as supervisions to guide the student network training. In addition, we apply adversarial learning to optimize the student network to recover the knowledge in teacher networks. To the best of our knowledge, we are the first to investigate the combination of NAS and knowledge distillation. The proposed method has been evaluated on the public OpenKBP dataset, and experimental results demonstrate the effectiveness of our method and its superior performance to the state-of-the-art method.