Longitudinal Bayesian Learning of Continuous Disease Position across the Alzheimer's Disease Continuum

Alzheimer's disease (AD) progresses as a continuous biological process, whereas most existing neuroimaging-based artificial intelligence methods remain limited to discrete diagnosis or clinical score prediction from cross-sectional imaging. In this work, we propose Disease Continuum Positioning (DCP), a longitudinal Bayesian Learning framework that continuously estimates disease severity from longitudinal diffusion tensor imaging (DTI). Specifically, DCP models disease severity as a low-dimensional probabilistic latent variable by jointly integrating longitudinal observations with weak clinical supervision, from which the proposed Disease Continuum Score (DCS) is derived to quantify an individual's position along the Alzheimer's disease continuum together with its associated uncertainty. Extensive experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort demonstrate that DCP consistently outperforms representative disease progression methods. More importantly, comprehensive validation analyses show that DCS accurately characterizes disease severity, exhibits strong clinical relevance, preserves longitudinal disease evolution, and predicts future disease conversion. These results suggest that DCS provides a quantitative imaging-derived representation for continuous assessment of Alzheimer's disease progression beyond conventional diagnostic labels and clinical scores.

A Multiple Radar Approach for Automatic Target Recognition of Aircraft using Inverse Synthetic Aperture Radar

Along with the improvement of radar technologies, Automatic Target Recognition (ATR) using Synthetic Aperture Radar (SAR) and Inverse SAR (ISAR) has come to be an active research area. SAR/ISAR are radar techniques to generate a two-dimensional high-resolution image of a target. Unlike other similar experiments using Convolutional Neural Networks (CNN) to solve this problem, we utilize an unusual approach that leads to better performance and faster training times. Our CNN uses complex values generated by a simulation to train the network; additionally, we utilize a multi-radar approach to increase the accuracy of the training and testing processes, thus resulting in higher accuracies than the other papers working on SAR/ISAR ATR. We generated our dataset with 7 different aircraft models with a radar simulator we developed called RadarPixel; it is a Windows GUI program implemented using Matlab and Java programming, the simulator is capable of accurately replicating a real SAR/ISAR configurations. Our objective is to utilize our multi-radar technique and determine the optimal number of radars needed to detect and classify targets.