An Agentic AI Framework to Accelerate Scientific Discovery in Plant Phenotyping

High-throughput plant phenotyping now generates image derived datasets far faster than scientists can analyze them. At Oak Ridge National Laboratory's Advanced Plant Phenotyping Laboratory (APPL), automated stations image hundreds of plants daily across multiple remote sensing modalities; yet, trait extraction and interpretation remain manual, expert-bound, and strictly post-hoc, making analysis, not acquisition, the binding constraint on discovery. We present an end-to-end agentic AI framework that turns the facility from a data factory into an interactive autonomous, discovery platform, where scientists partner with AI agents to accelerate time to insight. A conversational Co-Scientist Agent translates a scientist's natural-language question into a structured analysis plan, and a headless Compute Agent dispatches Vision Transformer segmentation and trait extraction on the Frontier exascale supercomputer. The two agents run in separate security and resource domains and communicate over a secure, token-authenticated streaming channel, a design that accounts for the federation, data-movement, and provenance realities cloud-native agentic frameworks ignore, ensuring end-to-end provenance is captured for every interaction. The framework turns a days- to weeks-long analysis process into an interactive loop where agents reason over results, recommend next analyses, and respond to follow-up questions in seconds.

LLM Agents for Interactive Workflow Provenance: Reference Architecture and Evaluation Methodology

Modern scientific discovery increasingly relies on workflows that process data across the Edge, Cloud, and High Performance Computing (HPC) continuum. Comprehensive and in-depth analyses of these data are critical for hypothesis validation, anomaly detection, reproducibility, and impactful findings. Although workflow provenance techniques support such analyses, at large scale, the provenance data become complex and difficult to analyze. Existing systems depend on custom scripts, structured queries, or static dashboards, limiting data interaction. In this work, we introduce an evaluation methodology, reference architecture, and open-source implementation that leverages interactive Large Language Model (LLM) agents for runtime data analysis. Our approach uses a lightweight, metadata-driven design that translates natural language into structured provenance queries. Evaluations across LLaMA, GPT, Gemini, and Claude, covering diverse query classes and a real-world chemistry workflow, show that modular design, prompt tuning, and Retrieval-Augmented Generation (RAG) enable accurate and insightful LLM agent responses beyond recorded provenance.

Distributed intelligence on the Edge-to-Cloud Continuum: A systematic literature review

The explosion of data volumes generated by an increasing number of applications is strongly impacting the evolution of distributed digital infrastructures for data analytics and machine learning (ML). While data analytics used to be mainly performed on cloud infrastructures, the rapid development of IoT infrastructures and the requirements for low-latency, secure processing has motivated the development of edge analytics. Today, to balance various trade-offs, ML-based analytics tends to increasingly leverage an interconnected ecosystem that allows complex applications to be executed on hybrid infrastructures where IoT Edge devices are interconnected to Cloud/HPC systems in what is called the Computing Continuum, the Digital Continuum, or the Transcontinuum.Enabling learning-based analytics on such complex infrastructures is challenging. The large scale and optimized deployment of learning-based workflows across the Edge-to-Cloud Continuum requires extensive and reproducible experimental analysis of the application execution on representative testbeds. This is necessary to help understand the performance trade-offs that result from combining a variety of learning paradigms and supportive frameworks. A thorough experimental analysis requires the assessment of the impact of multiple factors, such as: model accuracy, training time, network overhead, energy consumption, processing latency, among others.This review aims at providing a comprehensive vision of the main state-of-the-art libraries and frameworks for machine learning and data analytics available today. It describes the main learning paradigms enabling learning-based analytics on the Edge-to-Cloud Continuum. The main simulation, emulation, deployment systems, and testbeds for experimental research on the Edge-to-Cloud Continuum available today are also surveyed. Furthermore, we analyze how the selected systems provide support for experiment reproducibility. We conclude our review with a detailed discussion of relevant open research challenges and of future directions in this domain such as: holistic understanding of performance; performance optimization of applications;efficient deployment of Artificial Intelligence (AI) workflows on highly heterogeneous infrastructures; and reproducible analysis of experiments on the Computing Continuum.

Reproducible Performance Optimization of Complex Applications on the Edge-to-Cloud Continuum

In more and more application areas, we are witnessing the emergence of complex workflows that combine computing, analytics and learning. They often require a hybrid execution infrastructure with IoT devices interconnected to cloud/HPC systems (aka Computing Continuum). Such workflows are subject to complex constraints and requirements in terms of performance, resource usage, energy consumption and financial costs. This makes it challenging to optimize their configuration and deployment. We propose a methodology to support the optimization of real-life applications on the Edge-to-Cloud Continuum. We implement it as an extension of E2Clab, a previously proposed framework supporting the complete experimental cycle across the Edge-to-Cloud Continuum. Our approach relies on a rigorous analysis of possible configurations in a controlled testbed environment to understand their behaviour and related performance trade-offs. We illustrate our methodology by optimizing Pl@ntNet, a world-wide plant identification application. Our methodology can be generalized to other applications in the Edge-to-Cloud Continuum.