Building population models for large-scale neural recordings: opportunities and pitfalls

Modern extracellular recording technologies now enable simultaneous recording from large numbers of neurons. This has driven the development of new statistical models for analyzing and interpreting neural population activity. Here we provide a broad overview of recent developments in this area. We compare and contrast different approaches, highlight strengths and limitations, and discuss biological and mechanistic insights that these methods provide. While still an area of active development, there are already a number of powerful models for interpreting large scale neural recordings even in complex experimental settings.

Improving the Reconstruction of Disentangled Representation Learners via Multi-Stage Modelling

Current autoencoder-based disentangled representation learning methods achieve disentanglement by penalizing the (aggregate) posterior to encourage statistical independence of the latent factors. This approach introduces a trade-off between disentangled representation learning and reconstruction quality since the model does not have enough capacity to learn correlated latent variables that capture detail information present in most image data. To overcome this trade-off, we present a novel multi-stage modelling approach where the disentangled factors are first learned using a preexisting disentangled representation learning method (such as $\beta$-TCVAE); then, the low-quality reconstruction is improved with another deep generative model that is trained to model the missing correlated latent variables, adding detail information while maintaining conditioning on the previously learned disentangled factors. Taken together, our multi-stage modelling approach results in a single, coherent probabilistic model that is theoretically justified by the principal of D-separation and can be realized with a variety of model classes including likelihood-based models such as variational autoencoders, implicit models such as generative adversarial networks, and tractable models like normalizing flows or mixtures of Gaussians. We demonstrate that our multi-stage model has much higher reconstruction quality than current state-of-the-art methods with equivalent disentanglement performance across multiple standard benchmarks.

not-so-BigGAN: Generating High-Fidelity Images on a Small Compute Budget

BigGAN is the state-of-the-art in high-resolution image generation, successfully leveraging advancements in scalable computing and theoretical understanding of generative adversarial methods to set new records in conditional image generation. A major part of BigGAN's success is due to its use of large mini-batch sizes during training in high dimensions. While effective, this technique requires an incredible amount of compute resources and/or time (256 TPU-v3 Cores), putting the model out of reach for the larger research community. In this paper, we present not-so-BigGAN, a simple and scalable framework for training deep generative models on high-dimensional natural images. Instead of modelling the image in pixel space like in BigGAN, not-so-BigGAN uses wavelet transformations to bypass the curse of dimensionality, reducing the overall compute requirement significantly. Through extensive empirical evaluation, we demonstrate that for a fixed compute budget, not-so-BigGAN converges several times faster than BigGAN, reaching competitive image quality with an order of magnitude lower compute budget (4 Telsa-V100 GPUs).