PI-RADS v2 Compliant Automated Segmentation of Prostate Zones Using co-training Motivated Multi-task Dual-Path CNN

The detailed images produced by Magnetic Resonance Imaging (MRI) provide life-critical information for the diagnosis and treatment of prostate cancer. To provide standardized acquisition, interpretation and usage of the complex MRI images, the PI-RADS v2 guideline was proposed. An automated segmentation following the guideline facilitates consistent and precise lesion detection, staging and treatment. The guideline recommends a division of the prostate into four zones, PZ (peripheral zone), TZ (transition zone), DPU (distal prostatic urethra) and AFS (anterior fibromuscular stroma). Not every zone shares a boundary with the others and is present in every slice. Further, the representations captured by a single model might not suffice for all zones. This motivated us to design a dual-branch convolutional neural network (CNN), where each branch captures the representations of the connected zones separately. Further, the representations from different branches act complementary to each other at the second stage of training, where they are fine-tuned through an unsupervised loss. The loss penalises the difference in predictions from the two branches for the same class. We also incorporate multi-task learning in our framework to further improve the segmentation accuracy. The proposed approach improves the segmentation accuracy of the baseline (mean absolute symmetric distance) by 7.56%, 11.00%, 58.43% and 19.67% for PZ, TZ, DPU and AFS zones respectively.

StarGAN-VC++: Towards Emotion Preserving Voice Conversion Using Deep Embeddings

Voice conversion (VC) transforms an utterance to sound like another person without changing the linguistic content. A recently proposed generative adversarial network-based VC method, StarGANv2-VC is very successful in generating natural-sounding conversions. However, the method fails to preserve the emotion of the source speaker in the converted samples. Emotion preservation is necessary for natural human-computer interaction. In this paper, we show that StarGANv2-VC fails to disentangle the speaker and emotion representations, pertinent to preserve emotion. Specifically, there is an emotion leakage from the reference audio used to capture the speaker embeddings while training. To counter the problem, we propose novel emotion-aware losses and an unsupervised method which exploits emotion supervision through latent emotion representations. The objective and subjective evaluations prove the efficacy of the proposed strategy over diverse datasets, emotions, gender, etc.

Emo-StarGAN: A Semi-Supervised Any-to-Many Non-Parallel Emotion-Preserving Voice Conversion

Speech anonymisation prevents misuse of spoken data by removing any personal identifier while preserving at least linguistic content. However, emotion preservation is crucial for natural human-computer interaction. The well-known voice conversion technique StarGANv2-VC achieves anonymisation but fails to preserve emotion. This work presents an any-to-many semi-supervised StarGANv2-VC variant trained on partially emotion-labelled non-parallel data. We propose emotion-aware losses computed on the emotion embeddings and acoustic features correlated to emotion. Additionally, we use an emotion classifier to provide direct emotion supervision. Objective and subjective evaluations show that the proposed approach significantly improves emotion preservation over the vanilla StarGANv2-VC. This considerable improvement is seen over diverse datasets, emotions, target speakers, and inter-group conversions without compromising intelligibility and anonymisation.

TorchEsegeta: Framework for Interpretability and Explainability of Image-based Deep Learning Models

Clinicians are often very sceptical about applying automatic image processing approaches, especially deep learning based methods, in practice. One main reason for this is the black-box nature of these approaches and the inherent problem of missing insights of the automatically derived decisions. In order to increase trust in these methods, this paper presents approaches that help to interpret and explain the results of deep learning algorithms by depicting the anatomical areas which influence the decision of the algorithm most. Moreover, this research presents a unified framework, TorchEsegeta, for applying various interpretability and explainability techniques for deep learning models and generate visual interpretations and explanations for clinicians to corroborate their clinical findings. In addition, this will aid in gaining confidence in such methods. The framework builds on existing interpretability and explainability techniques that are currently focusing on classification models, extending them to segmentation tasks. In addition, these methods have been adapted to 3D models for volumetric analysis. The proposed framework provides methods to quantitatively compare visual explanations using infidelity and sensitivity metrics. This framework can be used by data scientists to perform post-hoc interpretations and explanations of their models, develop more explainable tools and present the findings to clinicians to increase their faith in such models. The proposed framework was evaluated based on a use case scenario of vessel segmentation models trained on Time-of-fight (TOF) Magnetic Resonance Angiogram (MRA) images of the human brain. Quantitative and qualitative results of a comparative study of different models and interpretability methods are presented. Furthermore, this paper provides an extensive overview of several existing interpretability and explainability methods.