PARK: Parkinson's Analysis with Remote Kinetic-tasks

We present a web-based framework to screen for Parkinson's disease (PD) by allowing users to perform neurological tests in their homes. Our web framework guides the users to complete three tasks involving speech, facial expression, and finger movements. The task videos are analyzed to classify whether the users show signs of PD. We present the results in an easy-to-understand manner, along with personalized resources to further access to treatment and care. Our framework is accessible by any major web browser, improving global access to neurological care.

Using AI to Measure Parkinson's Disease Severity at Home

We present an artificial intelligence system to remotely assess the motor performance of individuals with Parkinson's disease (PD). Participants performed a motor task (i.e., tapping fingers) in front of a webcam, and data from 250 global participants were rated by three expert neurologists following the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The neurologists' ratings were highly reliable, with an intra-class correlation coefficient (ICC) of 0.88. We developed computer algorithms to obtain objective measurements that align with the MDS-UPDRS guideline and are strongly correlated with the neurologists' ratings. Our machine learning model trained on these measures outperformed an MDS-UPDRS certified rater, with a mean absolute error (MAE) of 0.59 compared to the rater's MAE of 0.79. However, the model performed slightly worse than the expert neurologists (0.53 MAE). The methodology can be replicated for similar motor tasks, providing the possibility of evaluating individuals with PD and other movement disorders remotely, objectively, and in areas with limited access to neurological care.

Auto-Gait: Automatic Ataxia Risk Assessment with Computer Vision on Gait Task Videos

In this paper, we investigated whether we can 1) detect participants with ataxia-specific gait characteristics (risk-prediction), and 2) assess severity of ataxia from gait (severity-assessment). We collected 155 videos from 89 participants, 24 controls and 65 diagnosed with (or are pre-manifest) spinocerebellar ataxias (SCAs), performing the gait task of the Scale for the Assessment and Rating of Ataxia (SARA) from 11 medical sites located in 8 different states in the United States. We developed a method to separate the participants from their surroundings and constructed several features to capture gait characteristics like step width, step length, swing, stability, speed, etc. Our risk-prediction model achieves 83.06% accuracy and an 80.23% F1 score. Similarly, our severity-assessment model achieves a mean absolute error (MAE) score of 0.6225 and a Pearson's correlation coefficient score of 0.7268. Our models still performed competitively when evaluated on data from sites not used during training. Furthermore, through feature importance analysis, we found that our models associate wider steps, decreased walking speed, and increased instability with greater ataxia severity, which is consistent with previously established clinical knowledge. Our models create possibilities for remote ataxia assessment in non-clinical settings in the future, which could significantly improve accessibility of ataxia care. Furthermore, our underlying dataset was assembled from a geographically diverse cohort, highlighting its potential to further increase equity. The code used in this study is open to the public, and the anonymized body pose landmark dataset could be released upon approval from our Institutional Review Board (IRB).