SPORD: A Simulation-Propose-then-OR-Dispose Approach for Supply Chain Planning

For years, supply chain planning at e-commerce firms has operated as a collection of isolated projects. Each planning task from static network planning to dynamic warehouse assortment planning requires analysts to spend weeks building models from scratch, calibrating and persuading executives to act on outputs they cannot verify. Three barriers drive this: bespoke models proliferate because standardization is difficult (operational fragmentation); once unified, the combinatorial scale of millions of SKUs, thousands of nodes, and intricate routing logic exceeds what solvers can handle within a tight window (computational intractability); and a mathematically optimal solution still fails to be implemented if the executives do not trust it (implementation hurdle). To bridge this gap, we propose and implement the Simulation-Propose-then-OR-Dispose method, deployed as JD.com's NetSim platform. The central insight is decoupling: simulation proposes by generating and evaluating the full set of operationally valid candidate paths-absorbing all idiosyncratic business logic, while an integer program disposes by selecting the globally optimal subset. Computationally, matrix-vectorized CPU/GPU accelerated simulation achieves a 10-100 times speedup over serial methods, and a list scheduling algorithm reduces coupled-order processing from hours to minutes. Operationally, we establish a closed loop via an intelligent diagnosis engine. Since 2025, NetSim has optimized end to-end services for over 20,000 suppliers, the cross-regional fulfillment rate dropped from 6.1% to 4.9%, and the average monthly carbon reduction is approximately 5,745 tCO2e. SPORD moves simulation from monitoring to active planning. The transparent outputs turn skeptical executives into engaged collaborators, and the modular architecture ensures that the next planning requires just configuration, not reconstruction.

How We Won the ISLES'24 Challenge by Preprocessing

Stroke is among the top three causes of death worldwide, and accurate identification of stroke lesion boundaries is critical for diagnosis and treatment. Supervised deep learning methods have emerged as the leading solution for stroke lesion segmentation but require large, diverse, and annotated datasets. The ISLES'24 challenge addresses this need by providing longitudinal stroke imaging data, including CT scans taken on arrival to the hospital and follow-up MRI taken 2-9 days from initial arrival, with annotations derived from follow-up MRI. Importantly, models submitted to the ISLES'24 challenge are evaluated using only CT inputs, requiring prediction of lesion progression that may not be visible in CT scans for segmentation. Our winning solution shows that a carefully designed preprocessing pipeline including deep-learning-based skull stripping and custom intensity windowing is beneficial for accurate segmentation. Combined with a standard large residual nnU-Net architecture for segmentation, this approach achieves a mean test Dice of 28.5 with a standard deviation of 21.27.

Here Comes the Explanation: A Shapley Perspective on Multi-contrast Medical Image Segmentation

Deep learning has been successfully applied to medical image segmentation, enabling accurate identification of regions of interest such as organs and lesions. This approach works effectively across diverse datasets, including those with single-image contrast, multi-contrast, and multimodal imaging data. To improve human understanding of these black-box models, there is a growing need for Explainable AI (XAI) techniques for model transparency and accountability. Previous research has primarily focused on post hoc pixel-level explanations, using methods gradient-based and perturbation-based apporaches. These methods rely on gradients or perturbations to explain model predictions. However, these pixel-level explanations often struggle with the complexity inherent in multi-contrast magnetic resonance imaging (MRI) segmentation tasks, and the sparsely distributed explanations have limited clinical relevance. In this study, we propose using contrast-level Shapley values to explain state-of-the-art models trained on standard metrics used in brain tumor segmentation. Our results demonstrate that Shapley analysis provides valuable insights into different models' behavior used for tumor segmentation. We demonstrated a bias for U-Net towards over-weighing T1-contrast and FLAIR, while Swin-UNETR provided a cross-contrast understanding with balanced Shapley distribution.

An Ensemble Approach for Brain Tumor Segmentation and Synthesis

The integration of machine learning in magnetic resonance imaging (MRI), specifically in neuroimaging, is proving to be incredibly effective, leading to better diagnostic accuracy, accelerated image analysis, and data-driven insights, which can potentially transform patient care. Deep learning models utilize multiple layers of processing to capture intricate details of complex data, which can then be used on a variety of tasks, including brain tumor classification, segmentation, image synthesis, and registration. Previous research demonstrates high accuracy in tumor segmentation using various model architectures, including nn-UNet and Swin-UNet. U-Mamba, which uses state space modeling, also achieves high accuracy in medical image segmentation. To leverage these models, we propose a deep learning framework that ensembles these state-of-the-art architectures to achieve accurate segmentation and produce finely synthesized images.