Improving Robustness and Reliability in Medical Image Classification with Latent-Guided Diffusion and Nested-Ensembles

While deep learning models have achieved remarkable success across a range of medical image analysis tasks, deployment of these models in real clinical contexts requires that they be robust to variability in the acquired images. While many methods apply predefined transformations to augment the training data to enhance test-time robustness, these transformations may not ensure the model's robustness to the diverse variability seen in patient images. In this paper, we introduce a novel three-stage approach based on transformers coupled with conditional diffusion models, with the goal of improving model robustness to the kinds of imaging variability commonly encountered in practice without the need for pre-determined data augmentation strategies. To this end, multiple image encoders first learn hierarchical feature representations to build discriminative latent spaces. Next, a reverse diffusion process, guided by the latent code, acts on an informative prior and proposes prediction candidates in a generative manner. Finally, several prediction candidates are aggregated in a bi-level aggregation protocol to produce the final output. Through extensive experiments on medical imaging benchmark datasets, we show that our method improves upon state-of-the-art methods in terms of robustness and confidence calibration. Additionally, we introduce a strategy to quantify the prediction uncertainty at the instance level, increasing their trustworthiness to clinicians using them in clinical practice.

DCT-Mask: Discrete Cosine Transform Mask Representation for Instance Segmentation

Binary grid mask representation is broadly used in instance segmentation. A representative instantiation is Mask R-CNN which predicts masks on a $28\times 28$ binary grid. Generally, a low-resolution grid is not sufficient to capture the details, while a high-resolution grid dramatically increases the training complexity. In this paper, we propose a new mask representation by applying the discrete cosine transform(DCT) to encode the high-resolution binary grid mask into a compact vector. Our method, termed DCT-Mask, could be easily integrated into most pixel-based instance segmentation methods. Without any bells and whistles, DCT-Mask yields significant gains on different frameworks, backbones, datasets, and training schedules. It does not require any pre-processing or pre-training, and almost no harm to the running speed. Especially, for higher-quality annotations and more complex backbones, our method has a greater improvement. Moreover, we analyze the performance of our method from the perspective of the quality of mask representation. The main reason why DCT-Mask works well is that it obtains a high-quality mask representation with low complexity. Code will be made available.