ClinicalGPT: Large Language Models Finetuned with Diverse Medical Data and Comprehensive Evaluation

Large language models have exhibited exceptional performance on various Natural Language Processing (NLP) tasks, leveraging techniques such as the pre-training, and instruction fine-tuning. Despite these advances, their effectiveness in medical applications is limited, due to challenges such as factual inaccuracies, reasoning abilities, and lack grounding in real-world experience. In this study, we present ClinicalGPT, a language model explicitly designed and optimized for clinical scenarios. By incorporating extensive and diverse real-world data, such as medical records, domain-specific knowledge, and multi-round dialogue consultations in the training process, ClinicalGPT is better prepared to handle multiple clinical task. Furthermore, we introduce a comprehensive evaluation framework that includes medical knowledge question-answering, medical exams, patient consultations, and diagnostic analysis of medical records. Our results demonstrate that ClinicalGPT significantly outperforms other models in these tasks, highlighting the effectiveness of our approach in adapting large language models to the critical domain of healthcare.

Stochastically Dominant Distributional Reinforcement Learning

We describe a new approach for mitigating risk in the Reinforcement Learning paradigm. Instead of reasoning about expected utility, we use second-order stochastic dominance (SSD) to directly compare the inherent risk of random returns induced by different actions. We frame the RL optimization within the space of probability measures to accommodate the SSD relation, treating Bellman's equation as a potential energy functional. This brings us to Wasserstein gradient flows, for which the optimality and convergence are well understood. We propose a discrete-measure approximation algorithm called the Dominant Particle Agent (DPA), and we demonstrate how safety and performance are better balanced with DPA than with existing baselines.