Hybrid Full Waveform Inversion Assisted by Rytov Approximation for Musculoskeletal Ultrasound Computed Tomography

Ultrasound computed tomography is emerging as a promising safe and accessible modality for soft-tissue medical imaging, with full waveform inversion playing a key role in unlocking its full potential for high-resolution, quantitative reconstructions. Frequency domain full waveform inversion (FDFWI) for reconstructing spatial maps of acoustic properties in the musculoskeletal system is highly sensitive to the quality of low-frequency signals, making the final imaging outcome vulnerable to issues such as inappropriate initial models and strong scatterings related to bones. To address these challenges, we propose a hybrid full waveform inversion (HFWI) algorithm that incorporates a traveltime inversion algorithm based on the generalized Rytov approximation into the FDFWI framework. This hybrid strategy enhances early-stage inversion quality and substantially reduces sensitivity to the initial model, all while maintaining computational efficiency. Importantly, HFWI achieves results comparable to those obtained using well-constructed initial models, without incurring extra computational cost, thus enabling accurate imaging under realistic, bandwidth-limited conditions. In addition, we introduce a near real-time strategy to update first-arrival traveltimes based on forward-scattered phase variations without requiring extra wavefield simulations. Numerical simulations, as well as \textit{in vitro} and \textit{in vivo} experiments confirm the robustness and efficiency of the proposed approach. HFWI also shows promise to extend to more complex scenarios of musculoskeletal parametric reconstruction.

In vivo 3D ultrasound computed tomography of musculoskeletal tissues with generative neural physics

Ultrasound computed tomography (USCT) is a radiation-free, high-resolution modality but remains limited for musculoskeletal imaging due to conventional ray-based reconstructions that neglect strong scattering. We propose a generative neural physics framework that couples generative networks with physics-informed neural simulation for fast, high-fidelity 3D USCT. By learning a compact surrogate of ultrasonic wave propagation from only dozens of cross-modality images, our method merges the accuracy of wave modeling with the efficiency and stability of deep learning. This enables accurate quantitative imaging of in vivo musculoskeletal tissues, producing spatial maps of acoustic properties beyond reflection-mode images. On synthetic and in vivo data (breast, arm, leg), we reconstruct 3D maps of tissue parameters in under ten minutes, with sensitivity to biomechanical properties in muscle and bone and resolution comparable to MRI. By overcoming computational bottlenecks in strongly scattering regimes, this approach advances USCT toward routine clinical assessment of musculoskeletal disease.